Current Bioactive Compounds - Online First

Background Paracetamol overdose can lead to severe liver damage due to the formation of toxic metabolites. Casimiora edulis, rich in polyphenols and flavonoids, and silymarin, a known liver protectant, may help mitigate this damage. Objective This study aims to characterize the main phytoconstituents of Casimiora edulis leaves and evaluate their hepatoprotective activity. Methods Leaves of Casimiora edulis were extr Read More

A complicated neural developmental condition, autism spectrum disorder (ASD) is marked by difficulties with social interaction, communication, and repetitive behaviours. There is increasing interest in complementary and alternative medicines, including medicinal plants, to treat the symptoms of ASD as incidence rates rise globally. This thorough analysis looks at the available data supporting a range of plant-based ASD control Read More

Introduction This study explores the therapeutic potential of Bixa orellana (B. orellana), focusing on its bioactive compounds and antioxidant effects. Phytochemical analysis combined with network pharmacology was employed to investigate its multi-targeted therapeutic potential against oxidative stress. Methods The antioxidant activity of B. orellana flower extract was determined using DPPH assays. High-performance thi Read More

Epilepsy, a prevalent neurological disorder, affects approximately 1% of the Indian population, presenting a significant challenge in clinical management. Noninvasive treatment options are actively being explored, with nose-to-brain drug delivery emerging as a promising approach for effective epilepsy control. This comprehensive review delves into the potential of intranasal nanotherapy, focusing on its applicability in Read More

Diabetes mellitus is a chronic metabolic disorder which occurs due to deficiency of insulin or resistance to insulin receptor. There are naturally occurring compounds found in various plants, foods, and herbs that have potent anti-diabetic properties. They help to control blood sugar levels by increasing insulin sensitivity and stimulating glucose absorption in cells. Diosmin, a flavonoid glycoside found primarily in citrus fruits, has Read More

Background The use of plant extracts in the biosynthesis of nanoparticles has garnered attention in recent years due to the rapid, ecological, and economical production protocol. The current study aimed to biosynthesize silver nanoparticles (AgNPs) of Hypochaeris radicata L. extract. Methods These nanoparticles were characterized by UV-Vis, Fourier Transform Infrared Spectroscopy (FTIR), and X-Ray Diffraction (XRD) to deter Read More

Cancer is a highly fatal disease that is typified by aberrant cells proliferating out of control. The properties of acquired cells, including as genomic instability and mutations, cellular death evasion, and proliferative signaling sustenance, are evidenced by the hallmarks of cancer and contribute to the establishment of malignant tumors. A protein called poly(ADP-ribose) polymerase-1 (PARP1) is essential for both cell survival and DN Read More

The traditional use of medicinal plants holds a wealth of ancient wisdom that inspires modern research. Piper betle, generally recognized as betel leaf, is valued in traditional medicine systems across various cultures for its diverse health benefits. The betel leaves have several significant uses as antioxidant, anti-inflammatory, and antiapoptotic activity which help in neuroprotection. Many phytochemicals are present in the bete Read More

Background Inflammation, a crucial defense mechanism of the immune system, seeks to safeguard and restore tissue equilibrium in response to tissue damage or infection by pathogens. Key indicators of inflammation include redness, discomfort, swelling, warmth, and impaired function. However, unmanaged inflammation can lead to serious health issues. Objective The aim of this research work is to perform docking stu Read More