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image of Insights into the Phytochemical Profile and Therapeutical Potential of Withania Somnifera (L.) Dunal

Abstract

(L.) Dunal () is an herb commonly known by its English name Winter Cherry, and Ashwagandha in Hindi. It has been used as a traditional Rasayana herb for a long time. It is a rich reservoir of bioactive compounds known as withanolides, namely, withaferin-A and withanolide-D. Its current research covers many aspects of human health, which include anti-stress, anti-tumor, 9immuno-modulatory, hypocholesterolemic, hepatoprotective, hypoglycemic, diuretic, anti-convulsant, neurotropic, adaptogenic, and cardioprotective properties. This overview traditional uses, phytochemical, and pharmacological activities. However, in-depth studies are needed on the clinical use of against human diseases. Besides, detailed toxicological analysis is also to be performed for its safe and efficacious use in preclinical and clinical studies and as a health-promoting herb.

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2024-11-15

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References

  1. Munir N. Mahmood Z. Shahid M. Afzal M.N. Jahangir M. Ali Shah S.M. Tahir I.M. Riaz M. Hussain S. Akram M. Yousaf F. Withania somnifera chemical constituents’ in vitro antioxidant potential and their response on spermatozoa parameters. Dose Response 2022 20 1 10.1177/15593258221074936 35250408
    [Google Scholar]
  2. Kuboyama T. Tohda C. Zhao J.N. Hattori N. Masao K. Axon- or dendrite-prebdominant outgrowth induced by con-stituents from Ashwagandha. Neuroreport 2002 13 14 1715 1720 10.1097/00001756‑200210070‑00005 12395110
    [Google Scholar]
  3. Arora S. Dhillon S. Rani G. Nagpal A. The in vitro anti-bacterial/synergistic activities of Withania somnifera extracts. Fitoterapia 2004 75 3-4 385 388 10.1016/j.fitote.2004.01.002 15159002
    [Google Scholar]
  4. Bhatacharjee S.K. Handbook of medicinal plants. Jaipur Pointer Publishers 1998
    [Google Scholar]
  5. Andallu B. Radhika B. Hypoglycemic, diuretic and hypo-cholesterolemic effects of roots of W. somnifera. Indian J. Exp. Biol. 2000 38 607 609 11116534
    [Google Scholar]
  6. Harikrishnan B. Subhramanian P. Subash S. Effect of Withania somnifera root powder on the levels of circulatory lipid peroxidation and liver market enzymes in chronic hy-perammonemia. E-J. Chem. 2008 5 872 877
    [Google Scholar]
  7. Davis L. Kuttan G. Effect of Withania somnifera on DMBA induced carcinogenesis. J. Ethnopharmacol. 2001 75 2-3 165 168 10.1016/S0378‑8741(00)00404‑9 11297845
    [Google Scholar]
  8. Dhuley J.N. Retracted: nootropic‐like effect of ashwagandha (Withania somnifera L.) in mice. Phytother. Res. 2001 15 6 524 528 10.1002/ptr.874 11536383
    [Google Scholar]
  9. Singh S. Kumar S. Withania somnifera: The Indian ginseng ashwagandha. Withania somnifera: the Indian ginseng ashwagandha. Lucknow, India Central Institute of Medicinal and Aromatic Plants 1998 293
    [Google Scholar]
  10. Mikulska P. Malinowska M. Ignacyk M. Szustowski P. Nowak J. Pesta K. Szeląg M. Szklanny D. Judasz E. Ka-czmarek G. Ejiohuo O.P. Paczkowska-Walendowska M. Gościniak A. Cielecka-Piontek J. Ashwagandha (Withania somnifera) — Current research on the health-promoting activi-ties: A narrative review. Pharmaceutics 2023 15 4 1057 10.3390/pharmaceutics15041057 37111543
    [Google Scholar]
  11. Afewerky H.K. Ayodeji A.E. Tiamiyu B.B. Orege J.I. Okeke E.S. Oyejobi A.O. Bate P.N.N. Adeyemi S.B. Criti-cal review of the Withania somnifera (L.) Dunal: Ethnobota-ny, pharmacological efficacy, and commercialization signifi-cance in Africa. Bull. Natl. Res. Cent. 2021 45 1 176 10.1186/s42269‑021‑00635‑6 34697529
    [Google Scholar]
  12. Bonilla D.A. Moreno Y. Gho C. Petro J.L. Odriozola-Martínez A. Kreider R.B. Effects of ashwagandha (Withania somnifera) on physical performance: Systematic review and bayesian meta-analysis. J. Funct. Morphol. Kinesiol. 2021 6 1 20 10.3390/jfmk6010020 33670194
    [Google Scholar]
  13. Singh N. Bhalla M. De Jager P. Gilca M. An overview on ashwagandha: A Rasayana (rejuvenator) of Ayurveda. Afr. J. Tradit. Complement. Altern. Med. 2011 8 5S 208 213 10.4314/ajtcam.v8i5S.9 22754076
    [Google Scholar]
  14. Kirtikar K.R. Basu B. D Indian Medicinal Plants 1999
    [Google Scholar]
  15. Sangwan R.S. Chaurasiya N.D. Misra L.N. Lal P. Uniyal G.C. Sharma R. Sangwan N.S. Suri K.A. Qazi G.N. Tuli R.J.C.S. Phytochemical variability in commercial herbal prod-ucts and preparations of Withania somnifera (Ashwagandha). Curr. Sci. 2004 86 3 461 465
    [Google Scholar]
  16. Pullaiah T. Withania somnifera. Encyclopedia of world me-dicinal. Plants 2006 5 2071 2072
    [Google Scholar]
  17. Ganzera M. Choudhary M.I. Khan I.A. Quantitative HPLC analysis of withanolides in Withania somnifera. Fitoterapia 2003 74 1-2 68 76 10.1016/S0367‑326X(02)00325‑8 12628397
    [Google Scholar]
  18. Misra L. Mishra P. Pandey A. Sangwan R.S. Sangwan N.S. Tuli R. Withanolides from Withania somnifera roots. Phytochemistry 2008 69 4 1000 1004 10.1016/j.phytochem.2007.10.024 18061221
    [Google Scholar]
  19. Matsuda H. Murakami T. Kishi A. Yoshikawa M. Struc-tures of withanosides I, II, III, IV, V, VI, and VII, new with-anolide glycosides, from the roots of Indian Withania somnif-era Dunal. and inhibitory activity for tachyphylaxis to clonidine in isolated guinea-pig ileum. Bioorg. Med. Chem. 2001 9 6 1499 1507 10.1016/S0968‑0896(01)00024‑4 11408168
    [Google Scholar]
  20. Jia P.Y. Li L.Y. Li C.Y. Song D.W. Analysis of fatty acid composition of Rosa davurica pall. by gas chromatography-mass spectrometry. Zhongguo Shengwuzhipinxue Zazhi 2017 30 315 319
    [Google Scholar]
  21. Glotter E. Kirson I. Abraham A. Lavie D. Constituents of Withania somnifera dun-XIII. Tetrahedron 1973 29 10 1353 1364 10.1016/S0040‑4020(01)83156‑2
    [Google Scholar]
  22. Kirson I. Cohen A. Abraham A. Withanolides Q and R, two new 23-hydroxy-steroidal lactones. J. Chem. Soc., Perkin Trans. 1 1975 1 21 2136 2138 10.1039/p19750002136 1238430
    [Google Scholar]
  23. Kirson I. Abraham A. Lavie D. Chemical analysis of hy-brids of Withania somnifera L. (Dun.). 1. Chemotypes III (Is-rael) by Indian I (Delhi). Isr. J. Chem. 1977 16 1 20 24 10.1002/ijch.197700007
    [Google Scholar]
  24. Kumar A. Ali M. Mir S. A new withanolide from the roots of Withania somnifera. Indian J. Chem. 2004 43B 2001 2003
    [Google Scholar]
  25. Bessalle R. Lavie D. Withanolide C. A chlorinated with-anolide from Withania somnifera. Phytochemistry 1992 31 10 3648 3651 10.1016/0031‑9422(92)83749‑O
    [Google Scholar]
  26. Velde V.V. Lavie D. A Δ16-withanolide in Withania somnif-era as a possible precursor for α-side-chains. Phytochemistry 1982 21 3 731 733 10.1016/0031‑9422(82)83176‑2
    [Google Scholar]
  27. Subramanian S. Sethi P.D. Chemical components of With-ania somnifera leaves. Indian J. Pharm. Sci. 1970 32 16 17
    [Google Scholar]
  28. Misra L. Lal P. Sangwan R.S. Sangwan N.S. Uniyal G.C. Tuli R. Unusually sulfated and oxygenated steroids from Withania somnifera. Phytochemistry 2005 66 23 2702 2707 10.1016/j.phytochem.2005.10.001 16293277
    [Google Scholar]
  29. Ali M. Shuaib M. Ansari S.H. Withanolides from the stem bark of Withania somnifera. Phytochemistry 1997 44 6 1163 1168 10.1016/S0031‑9422(96)00656‑5
    [Google Scholar]
  30. Kirson I. Glotter E. Lavis D. Abraham A. Constituents of Withania somnifera Dunal XII. The withanolides of an Indian chemotype. J. Chem. Soc. 1971 52 2032 2044
    [Google Scholar]
  31. Choudhary M.I. Hussain S. Yousuf S. Dar A. Mudassar; Rahman, A.U. Chlorinated and diepoxywithanolides from Withania somnifera and their cytotoxic effects against human lung cancer cell line. Phytochemistry 2010 71 2205 2209 10.1016/j.phytochem.2010.08.019 21044792
    [Google Scholar]
  32. Gómez Afonso A. Fernandez-Lazaro D. Adams D.P. Monserdà-Vilaró A. Fernandez-Lazaro C.I. Effects of With-ania somnifera (Ashwagandha) on hematological and bio-chemical markers, hormonal behavior, and oxidant response in healthy adults: A systematic review. Curr. Nutr. Rep. 2023 12 3 465 477 10.1007/s13668‑023‑00481‑0 37428341
    [Google Scholar]
  33. Ames B.N. Shigenaga M.K. Hagen T.M. Oxidants, antioxi-dants, and the degenerative diseases of aging. Proc. Natl. Acad. Sci. USA 1993 90 17 7915 7922 10.1073/pnas.90.17.7915 8367443
    [Google Scholar]
  34. Halliwell B. Gutteridge J.M.C. Free radicals in biology and medicine. 4th ed New York Oxford University Press 2007
    [Google Scholar]
  35. Kashyap V.K. Peasah-Darkwah G. Dhasmana A. Jaggi M. Yallapu M.M. Chauhan S.C. Withania somnifera: Pro-gress towards a pharmaceutical agent for immunomodulation and cancer therapeutics. Pharmaceutics 2022 14 3 611 10.3390/pharmaceutics14030611 35335986
    [Google Scholar]
  36. Russo A. Izzo A.A. Cardile V. Borrelli F. Selective killing of cancer Cells by leaf extract of Ashwagandha: Identification of a tumor. Phytother. Res. 2001 5 240 244
    [Google Scholar]
  37. Gupta S.K. Dua A. Vohra B.P.S. Withania somnifera (ashwagandha) attenuates antioxidant defense in aged spinal cord and inhibits copper induced lipid peroxidation and pro-tein oxidative modifications. Drug Metabol. Drug Interact. 2003 19 3 211 222 10.1515/DMDI.2003.19.3.211 14682611
    [Google Scholar]
  38. Bhattacharya S.K. Bhattacharya A. Sairam K. Ghosal S. Anxiolytic-antidepressant activity of Withania somnifera gly-cowithanolides: An experimental study. Phytomedicine 2000 7 6 463 469 10.1016/S0944‑7113(00)80030‑6 11194174
    [Google Scholar]
  39. Chandrasekhar K. Kapoor J. Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J. Psychol. Med. 2012 34 3 255 262 10.4103/0253‑7176.106022 23439798
    [Google Scholar]
  40. Sandhu J. Shah B. Shenoy S. Chauhan S. Lavekar G.S. Padhi M.M. Effects of Withania somnifera (Ashwagandha) and Terminalia arjuna (Arjuna) on physical performance and cardiorespiratory endurance in healthy young adults. Int. J. Ayurveda Res. 2010 1 3 144 149 10.4103/0974‑7788.72485 21170205
    [Google Scholar]
  41. Visavadiya N.P. Narasimhacharya A.V.R.L. Hypocho-lesteremic and antioxidant effects of Withania somnifera (Du-nal) in hypercholesteremic rats. Phytomedicine 2007 14 2-3 136 142 10.1016/j.phymed.2006.03.005 16713218
    [Google Scholar]
  42. Mayola E. Gallerne C. Esposti D.D. Martel C. Pervaiz S. Larue L. Debuire B. Lemoine A. Brenner C. Lemaire C. Withaferin A induces apoptosis in human melanoma cells through generation of reactive oxygen species and down-regulation of Bcl-2. Apoptosis 2011 16 10 1014 1027 10.1007/s10495‑011‑0625‑x 21710254
    [Google Scholar]
  43. Ambiye V.R. Langade D. Dongre S. Aptikar P. Kulkarni M. Dongre A. Clinical evaluation of the spermatogenic ac-tivity of the root extract of ashwagandha (Withania somnifera) in oligospermic males: A pilot study. Evid. Based Complement. Alternat. Med. 2013 2013 1 6 10.1155/2013/571420 24371462
    [Google Scholar]
  44. Ahmad M.K. Mahdi A.A. Shukla K.K. Islam N. Ra-jender S. Madhukar D. Shankhwar S.N. Ahmad S. With-ania somnifera improves semen quality by regulating repro-ductive hormone levels and oxidative stress in seminal plas-ma of infertile males. Fertil. Steril. 2010 94 3 989 996 10.1016/j.fertnstert.2009.04.046 19501822
    [Google Scholar]
  45. Khazal K.F. Hill D.L. Grubbs C.J. Effect of Withania som-nifera root extract on spontaneous estrogen receptor-negative mammary cancer in MMTV/Neu mice. Anticancer Res. 2014 34 11 6327 6332 25368231
    [Google Scholar]
  46. Tohda C. Kuboyama T. Komatsu K. Dendrite extension by methanol extract of Ashwagandha (roots of Withania somnif-era) in SK-N-SH cells. Neuroreport 2000 11 9 1981 1985 10.1097/00001756‑200006260‑00035 10884056
    [Google Scholar]
  47. Nakayama N. Tohda C. Withanoside IV improves hindlimb function by facilitating axonal growth and increase in periph-eral nervous system myelin level after spinal cord injury. Neurosci. Res. 2007 58 2 176 182 10.1016/j.neures.2007.02.014 17386954
    [Google Scholar]
  48. Kurapati K.R.V. Atluri V.S.R. Samikkannu T. Nair M.P.N. Ashwagandha (Withania somnifera) reverses β-amyloid1-42 induced toxicity in human neuronal cells: Impli-cations in HIV-associated neurocognitive disorders (HAND). PLoS One 2013 8 10 e77624 10.1371/journal.pone.0077624 24147038
    [Google Scholar]
  49. Grover A. Shandilya A. Agrawal V. Bisaria V.S. Sundar D. Computational evidence to inhibition of human acetyl cho-linesterase by withanolide a for Alzheimer treatment. J. Biomol. Struct. Dyn. 2012 29 4 651 662 10.1080/07391102.2012.10507408 22208270
    [Google Scholar]
  50. Kumar P. Kumar A. Possible neuroprotective effect of Withania somnifera root extract against 3-nitropropionic acid-induced behavioral, biochemical, and mitochondrial dysfunc-tion in an animal model of Huntington’s disease. J. Med. Food 2009 12 3 591 600 10.1089/jmf.2008.0028 19627208
    [Google Scholar]
  51. Kaurav B.P.S. Wanjari M.M. Chandekar A. Chauhan N.S. Upmanyu N. Influence of Withania somnifera on ob-sessive compulsive disorder in mice. Asian Pac. J. Trop. Med. 2012 5 5 380 384 10.1016/S1995‑7645(12)60063‑7 22546655
    [Google Scholar]
  52. Haque I.M. Mishra A. Kalra B.S. Chawla S. Role of standardized plant extracts in controlling alcohol withdrawal syndrome - An experimental study. Brain Sci. 2021 11 7 919 10.3390/brainsci11070919 34356153
    [Google Scholar]
  53. Nayak S. Nayak S. Panda B.K. Das S. A Clinical Study on management of stress in type-2 diabetes mellitus (Madhume-ha) with Ashwagandha (Withania Somnifera). Ayushdhara 2015 2 413 417
    [Google Scholar]
  54. Kelgane S.B. Salve J. Sampara P. Debnath K. Efficacy and tolerability of ashwagandha root extract in the elderly for improvement of general well-being and sleep: A prospective, randomized, double-blind, placebo-controlled study. Cureus 2020 12 2 e7083 10.7759/cureus.7083 32226684
    [Google Scholar]
  55. Kaushik M.K. Kaul S.C. Wadhwa R. Yanagisawa M. Urade Y. Triethylene glycol, an active component of Ashwa-gandha (Withania somnifera) leaves, is responsible for sleep induction. PLoS One 2017 12 2 e0172508 10.1371/journal.pone.0172508 28207892
    [Google Scholar]
  56. Gupta S.K. Mohanty I. Talwar K.K. Dinda A. Joshi S. Bansal P. Saxena A. Arya D.S. Cardioprotection from is-chemia and reperfusion injury by Withania somnifera: A he-modynamic, biochemical and histopathological assessment. Mol. Cell. Biochem. 2004 260 1-2 39 47 15228084
    [Google Scholar]
  57. Sayed N. Khurana A. Saifi M.A. Singh M. Godugu C. Withaferin A reverses bile duct ligation‐induced liver fibrosis by modulating extracellular matrix deposition: Role of LOXL2/Snail1, vimentin, and NFκB signaling. Biofactors 2019 45 6 959 974 10.1002/biof.1546 31336025
    [Google Scholar]
  58. Saleem S. Muhammad G. Hussain M.A. Altaf M. Bukha-ri S.N.A. Withania somnifera L.: Insights into the phytochem-ical profile, therapeutic potential, clinical trials, and future prospective. Iran. J. Basic Med. Sci. 2020 23 12 1501 1526 10.22038/IJBMS.2020.44254.10378 33489024
    [Google Scholar]
  59. Xia Y. Wang P. Yan N. Gonzalez F.J. Yan T. Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3. Cell Death Dis. 2021 12 2 174 10.1038/s41419‑020‑03243‑w 33574236
    [Google Scholar]
  60. Xia Y. Yan M. Wang P. Hamada K. Yan N. Hao H. Gonzalez F.J. Yan T. Withaferin A in the treatment of liver diseases: Progress and pharmacokinetic insights. Drug Metab. Dispos. 2022 50 5 685 693 10.1124/dmd.121.000455 34903587
    [Google Scholar]
  61. Malik T. Pandey D.K. Dogra N. Ameliorative potential of aqueous root extract of Withania somnifera against paraceta-mol induced liver damage in mice. Pharmacologia 2013 4 2 89 94 10.5567/pharmacologia.2013.89.94
    [Google Scholar]
  62. Vedi M. Rasool M. Sabina E.P. Amelioration of bromo-benzene hepatotoxicity by Withania somnifera pretreatment: Role of mitochondrial oxidative stress. Toxicol. Rep. 2014 1 629 638 10.1016/j.toxrep.2014.08.009 28962276
    [Google Scholar]
  63. Vedi M. Sabina E.P. Assessment of hepatoprotective and nephroprotective potential of withaferin A on bromobenzene-induced injury in Swiss albino mice: Possible involvement of mitochondrial dysfunction and inflammation. Cell Biol. Toxicol. 2016 32 5 373 390 10.1007/s10565‑016‑9340‑2 27250656
    [Google Scholar]
  64. Kasture S. Vinci S. Ibba F. Puddu A. Marongiu M. Murali B. Pisanu A. Lecca D. Zernig G. Acquas E. Withania somnifera prevents morphine withdrawal-induced decrease in spine density in nucleus accumbens shell of rats: A confocal laser scanning microscopy study. Neurotox. Res. 2009 16 4 343 355 10.1007/s12640‑009‑9069‑2 19551457
    [Google Scholar]
  65. Jayaprakasam B. Zhang Y. Seeram N.P. Nair M.G. Growth inhibition of human tumor cell lines by withanolides from Withania somnifera leaves. Life Sci. 2003 74 1 125 132 10.1016/j.lfs.2003.07.007 14575818
    [Google Scholar]
  66. Christina A.J.M. Joseph D.G. Packialakshmi M. Kothai R. Robert S.J.H. Chidambaranathan N. Ramasamy M. An-ticarcinogenic activity of Withania somnifera Dunal against Dalton’s ascitic lymphoma. J. Ethnopharmacol. 2004 93 2-3 359 361 10.1016/j.jep.2004.04.004 15234777
    [Google Scholar]
  67. Alanazi H.H. Elfaki E. The immunomodulatory role of Withania somnifera (L.) dunal in inflammatory diseases. Front. Pharmacol. 2023 14 1084757 10.3389/fphar.2023.1084757 36909188
    [Google Scholar]
  68. Iuvone T. Esposito G. Capasso F. Izzo A.A. Induction of nitric oxide synthase expression by Withania somnifera in macrophages. Life Sci. 2003 72 14 1617 1625 10.1016/S0024‑3205(02)02472‑4 12551750
    [Google Scholar]
  69. Owais M. Sharad K.S. Shehbaz A. Saleemuddin M. Anti-bacterial efficacy of Withania somnifera (ashwagandha) an in-digenous medicinal plant against experimental murine salmo-nellosis. Phytomedicine 2005 12 3 229 235 10.1016/j.phymed.2003.07.012 15830846
    [Google Scholar]
  70. Khanchandani N. Shah P. Kalwani T. Ardeshna A. Dharajiya D. Antibacterial and antifungal activity of ashwa-gandha (Withania somnifera L.): A review. J. Drug Deliv. Ther. 2019 9 5-s 154 161 10.22270/jddt.v9i5‑s.3573
    [Google Scholar]
  71. Batista B.G. Chaves M.A. Reginatto P. Saraiva O.J. Fuentefria A.M. Human fusariosis: An emerging infection that is difficult to treat. Rev. Soc. Bras. Med. Trop. 2020 53 e20200013 10.1590/0037‑8682‑0013‑2020 32491099
    [Google Scholar]
  72. Klich M.A. Aspergillus flavus: The major producer of aflatox-in. Mol. Plant Pathol. 2007 8 6 713 722 10.1111/j.1364‑3703.2007.00436.x 20507532
    [Google Scholar]
  73. Richy F. Bruyere O. Ethgen O. Cucherat M. Henrotin Y. Reginster J.Y. Structural and symptomatic efficacy of glu-cosamine and chondroitin in knee osteoarthritis: A compre-hensive meta-analysis. Arch. Intern. Med. 2003 163 13 1514 1522 10.1001/archinte.163.13.1514 12860572
    [Google Scholar]
  74. Smith G.N. Yu L.P. Brandt K.D. Capello W.N. Oral ad-ministration of doxycycline reduces collagenase and gelati-nase activities in extracts of human osteoarthritic cartilage. J. Rheumatol. 1998 25 3 532 535 9517776
    [Google Scholar]
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Insights into the Phytochemical Profile and Therapeutical Potential of Withania Somnifera (L.) Dunal
Bentham Science Publishers ; https://doi.org/10.2174/0115734072322568241018054129
/content/journals/cbc/10.2174/0115734072322568241018054129
/content/journals/cbc/10.2174/0115734072322568241018054129
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  • Article Type:     Research Article
Keywords: Ashwagandha ; withaferin A ; Withania somnifera (L.) dunal ; herbal medicine ; solanaceae

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