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image of An Assessment of Antidepressant Activity of Etlingera elatior Alone and in Combination with Fluoxetine

Abstract

Aim

Present study deals to access the antidepressant activity of leaves extract in rodent.

Background

is a species of herbaceous perennial plant in the family Zingiberaceae; native to Indonesia, Thailand, Malaysia and New Guinea. Depression is one of the most common mental disorders affecting humans, pathological basis of which is not fully understood. The current antidepressant drugs have several adverse effects including their effects on cognition. Therefore, natural product are being evaluated for their antidepressant activities.

Objective

In this study, leaf extracts are being evaluated for antidepressant activity in rodent models. A wide range of synthetic medicines that can be used to treat depression which may exerts various side effects such as dry mouth, gastrointestinal problems, nausea, respiratory problems, cardiac arrhythmias, drowsiness, anxiety etc. Hence, it becomes essential to discover new anti-depressant drug with more potency, efficacy and safety profile than those of marketed synthetic drugs.

Methods

Using the forced swimming test, the tail suspension test, mouse 5-HTP-induced head twitches and estimation of brain lipid peroxidation modelsthe antidepressant efficacy of ethanolic extract was examined. Imipramine was used as reference standards.

Results

According to our study, significantly (p 0.01) reduced immobility in tail suspension, forced swimming, and 5-HTP-induced head twitches in mice with depression that were comparable to imipramine.

Conclusion

Based on the results obtained we can conclude that leaves extract possess significant antidepressant activity. The antidepressant effectiveness of leaves extract can be confirmed in the future by adding more models, and attempts can also be made to isolate and characterise the phytoconstituents responsible for the pharmacological action.

© 2024 Bentham Science Publishers
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2024-10-09
2024-11-15

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References

  1. Dunn A.L. Trivedi M.H. Kampert J.B. Clark C.G. Chambliss H.O. Exercise treatment for depression. Am. J. Prev. Med. 2005 28 1 1 8 10.1016/j.amepre.2004.09.003 15626549
    [Google Scholar]
  2. Thurgood S. Avery M.D. Williamson L. Postpartum depression in women. Am. J. Chin. Med. 2009 6 2 17 22
    [Google Scholar]
  3. Whisman M.A. Kwon P. Parental representations, cognitive distortions, and mild depression. Cognit. Ther. Res. 1992 16 5 557 568 10.1007/BF01175141
    [Google Scholar]
  4. Asif M. Kumar A. Acute toxicity study and in-vivo anti-inflammatory activity of different fractions of Curculigo orchioides Gaertn. rhizome in albino Wistar rats. Indian J. Pharm. Sci. 2010 6 3 191 198
    [Google Scholar]
  5. Singh J. Jain S.P. Khanuja S.P. Curculigo orchioides Gaertn.(Kali Musali): An endangered medicinal plant of commercial value. Nat. Prod. Radiance 2006 5 5 369 372
    [Google Scholar]
  6. Jackie T. Haleagrahara N. Chakravarthi S. Antioxidant effects of Etlingera elatior flower extract against lead acetate - induced perturbations in free radical scavenging enzymes and lipid peroxidation in rats. BMC Res. Notes 2011 4 1 67 10.1186/1756‑0500‑4‑67 21414212
    [Google Scholar]
  7. Nair R. Kalariya T. Chanda S. Antibacterial activity of some selected Indian medicinal flora. Turk. J. Biol. 2005 29 1 7
    [Google Scholar]
  8. Ali N.A.A. Jülich W.D. Kusnick C. Lindequist U. Screening of Yemeni medicinal plants for antibacterial and cytotoxic activities. J. Ethnopharmacol. 2001 74 2 173 179 10.1016/S0378‑8741(00)00364‑0 11167035
    [Google Scholar]
  9. Larsen K. Ibrahim H. Khaw S.H. Saw L.G. Gingers of Peninsular Malaysia and Singapore. Kota Kinabalu: Natural History Publications (Borneo). 1999
    [Google Scholar]
  10. Ibrahim H. Setyowati F.M. Plant resources of South-East Asia. Wageningen Pudoc Scientific Publishers 1999 123 126
    [Google Scholar]
  11. New OCED 425 Guidelines. OECD Guidelines for Testing Animals. 2001
    [Google Scholar]
  12. Steru L. Chermat R. Thierry B. Simon P. The tail suspension test: A new method for screening antidepressants in mice. Psychopharmacology (Berl.) 1985 85 3 367 370 10.1007/BF00428203 3923523
    [Google Scholar]
  13. Ana Lúcia B. Ferulic acid exerts antidepressant-like effect in the tail suspension test 11 in mice: Evidence for the involvement of the serotonergic system. Eur. J. Pharmacol. 2012 679 1-3 68 74 10.1016/j.ejphar.2011.12.041 22266492
    [Google Scholar]
  14. Porsolt R.D. Bertin A. Jalfre M. Behavioral despair in mice: a primary screening test for antidepressants. Arch. Int. Pharmacodyn. Ther. 1977 229 2 327 336 596982
    [Google Scholar]
  15. Sánchez-Mateo C.C. Bonkanka C.X. Prado B. Rabanal R.M. Antidepressant activity of some Hypericum reflexum L. fil. extracts in the forced swimming test in mice. J. Ethnopharmacol. 2007 112 1 115 121 10.1016/j.jep.2007.02.019 17383128
    [Google Scholar]
  16. Bhattamisra S.K. Khanna V.K. Agrawal A.K. Singh P.N. Singh S.K. Antidepressant activity of standardised extract of Marsilea minuta Linn. J. Ethnopharmacol. 2008 117 1 51 57 10.1016/j.jep.2008.01.012 18299179
    [Google Scholar]
  17. Singh G.K. Garabadu D. Muruganandam A.V. Joshi V.K. Krishnamurthy S. Antidepressant activity of Asparagus racemosus in rodent models. Pharmacol. Biochem. Behav. 2009 91 3 283 290 10.1016/j.pbb.2008.07.010 18692086
    [Google Scholar]
  18. Halberstadt A.L. Geyer M.A. Characterization of the head-twitch response induced by hallucinogens in mice. Psychopharmacology (Berl.) 2013 227 4 727 739 10.1007/s00213‑013‑3006‑z 23407781
    [Google Scholar]
  19. Dhingra D. Bhankher A. Behavioral and biochemical evidences for antidepressant-like activity of palmatine in mice subjected to chronic unpredictable mild stress. Pharmacol. Rep. 2014 66 1 1 9 10.1016/j.pharep.2013.06.001 24905299
    [Google Scholar]
  20. Ullas P.D. Chandrashekar K.S. Abhinand P.K. Partha B. Vasudev P. Aravind P. Chemical composition and evaluation of antiepileptic activity of leaf extract of Cucurbita moschata in experimental animals. Eur. Chem. Bull. 2023 12 10 42 52
    [Google Scholar]
/content/journals/cbc/10.2174/0115734072328715240930043655
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An Assessment of Antidepressant Activity of Etlingera elatior Alone and in Combination with Fluoxetine
Bentham Science Publishers ; https://doi.org/10.2174/0115734072328715240930043655
/content/journals/cbc/10.2174/0115734072328715240930043655
/content/journals/cbc/10.2174/0115734072328715240930043655
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  • Article Type:     Research Article
Keywords: forced swimming test ; 5-HTP induced head twitches ; immobility time ; Etlingera elatior ; tail suspension test ; Antidepressant activity

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