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image of Acacia catechu: Comprehensive Review of Traditional Use, Phytochemicals and Pharmacology

Abstract

Aim and Objectives

This review aims to discuss the traditional applications, ethnobotanical significance, phytochemistry, and pharmacological profile of (). By examining the crude extracts, isolated components, and various fractions of the plant, the review seeks to identify potential new therapeutic agents.

Material and Methods

The available published literature on the plant was searched in databases like Scopus, Google Scholar, Science Direct, ACS, Wiley, Web of Science, Springer Link, and PubMed for all appropriate information to bring this review in place. In addition, other official electronic sources like the Encyclopedia Britannica and Northern Regional Center of the Botanical Survey of India, along with the links theplantlist.org, were also searched. In addition to these sources, some book chapters and books were also searched for the same.

Results

is a well-documented tree with numerous medicinal uses, widely utilized in Asia and beyond. The plant exhibits various pharmacological properties, including antibacterial effects, antidiarrheal activity, analgesic properties, cholesterol-lowering capabilities, ulcer protection, antidiabetic effects, inhibition of cell growth and anti-inflammatory actions.

Conclusion

This article goes into great detail about plants, ethnopharmacology, phytochemistry, pharmacology and toxicity studies.

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2024-12-04
2025-01-18
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References

  1. Thangavelu L. Balusamy S.R. Shanmugam R. Sivanesan S. Devaraj E. Rajagopalan V. Veeraiyan D.N. Chellappan D.K. Dua K. Kim Y.J. Perumalsamy H. Evaluation of the sub-acute toxicity of Acacia catechu Willd seed extract in a Wistar albino rat model. Regul. Toxicol. Pharmacol. 2020 113 104640 10.1016/j.yrtph.2020.104640 32169672
    [Google Scholar]
  2. Kumar R. Mahey S. Arora R. Mahajan J. Kumar V. Arora S. Insights into biological properties of less explored bark of industrially important Acacia catechu willd. Ind. Crops Prod. 2019 138 111486 10.1016/j.indcrop.2019.111486
    [Google Scholar]
  3. Sunil M.A. Sunitha V.S. Radhakrishnan E.K. Jyothis M. Immunomodulatory activities of Acacia catechu, a traditional thirst quencher of South India. J. Ayurveda Integr. Med. 2019 10 3 185 191 10.1016/j.jaim.2017.10.010 29502869
    [Google Scholar]
  4. Shen D. Wu Q. Wang M. Yang Y. Lavoie E.J. Simon J.E. Determination of the predominant catechins in Acacia catechu by liquid chromatography/electrospray ionization-mass spectrometry. J. Agric. Food Chem. 2006 54 9 3219 3224 10.1021/jf0531499 16637676
    [Google Scholar]
  5. Ismail S. Asad M. Immunomodulatory activity of Acacia catechu. Indian J. Physiol. Pharmacol. 2009 53 1 25 33 19810573
    [Google Scholar]
  6. Williamson E.M. Major herbs of ayurveda Churchill publishers Livingstone 2002
    [Google Scholar]
  7. Kumari M. Radha M. Acacia catechu (L.f.) Willd.: A review on bioactive compounds and their health promoting functionalities. Plants (Basel) 2022 11 22 3091 10.3390/plants11223091
    [Google Scholar]
  8. Rai A. Fazil M. Rasheed A. Ahmad B. Parveen S. Nikhat S. Role of Unani medicines in oro-dental diseases: A comprehensive review and scientific evidence Fortune J. Heal. Sci. 2020 3 30 54
    [Google Scholar]
  9. Saini M.L. Saini R. Roy S. Kumar A. Comparative pharmacognostical and antimicrobial studies of acacia species (Mimosaceae). J. Med. Plants Res. 2008 2 378 386
    [Google Scholar]
  10. Alambayan J. Vats M. Sardana S. Sehrawat R. Evaluation of antiulcer activity of roots of Acacia catechu Willd. (Mimosoideae). J. Pharmacogn. Phytochem. 2015 3 79 84
    [Google Scholar]
  11. Kumar R. Kaur R. Singh A.P. Arora S. Diminution of hepatic response to 7, 12-dimethylbenz(α)anthracene by ethyl acetate fraction of Acacia catechu willd. through modulation of xenobiotic and anti-oxidative enzymes in rats. PLoS One 2014 9 2 e90083 10.1371/journal.pone.0090083 24587216
    [Google Scholar]
  12. Rahmatullah M. Hossain M. Mahmud A. Sultana N. Rahman S.M. Islam M.R. Khatoon M.S. Jahan S. Islam F. Islam F. Antihyperglycemic and antinociceptive activity evaluation of ‘khoyer’ prepared from boiling the wood of Acacia catechu in water. Afr. J. Tradit. Complement. Altern. Med. 2013 10 4 1 5 10.4314/ajtcam.v10i4.1 24146493
    [Google Scholar]
  13. Sharma P. Lingha R. A recent update on the Pharmacognostical as well as pharmacological profiles of the Acacia catechu heartwood: A mini review. JAHM 2021 7 3 188 192 10.31254/jahm.2021.7304
    [Google Scholar]
  14. Voravuthikunchai S. Lortheeranuwat A. Jeeju W. Sririrak T. Phongpaichit S. Supawita T. Effective medicinal plants against enterohaemorrhagic Escherichia coli O157:H7. J. Ethnopharmacol. 2004 94 1 49 54 10.1016/j.jep.2004.03.036 15261962
    [Google Scholar]
  15. Hiraganahalli B.D. Chinampudur V.C. Dethe S. Mundkinajeddu D. Pandre M.K. Balachandran J. Agarwal A. Hepatoprotective and antioxidant activity of standardized herbal extracts. Pharmacogn. Mag. 2012 8 30 116 123 10.4103/0973‑1296.96553 22701284
    [Google Scholar]
  16. Bhardwaj K. Dhanjal D.S. Sharma A. Nepovimova E. Kalia A. Thakur S. Bhardwaj S. Chopra C. Singh R. Verma R. Kumar D. Bhardwaj P. Kuča K. Conifer-derived metallic nanoparticles: Green synthesis and biological applications Int. J. Mol. Sci. 2020 21 23 9028 10.3390/ijms21239028
    [Google Scholar]
  17. Thakur A.V. Ambwani T.K. Anupsingh V. Thakur S. Ambwani T. Kumar A. Preliminary phytochemical screening and GC-MS analysis of leaf extract of Acacia catechu (L.f.) Willd, ~ 81 ~. Int. J. Herb. Med. 2018 ••• 6
    [Google Scholar]
  18. Article R. Kumar U. Comparative analysis of antioxidant activity and phytochemical screening of some Indian medicinal plants Int. J. Pharm. Pharm. Sci. 2012 4 291 295
    [Google Scholar]
  19. Saha M.R. Dey P. Begum S. De B. Chaudhuri T.K. Sarker D.D. Das A.P. Sen A. Effect of Acacia catechu (L.f.) Willd. on oxidative stress with possible implications in alleviating selected cognitive disorders. PLoS One 2016 11 3 e0150574 10.1371/journal.pone.0150574 26949964
    [Google Scholar]
  20. Huda N. Thangavelu L. Roy A. Lipolysis assay in adipocytes acacia leaf in-vitro study. J. Adv. Pharm. Educ. Res. 2018 8 32 35 10.1146/annurev.nutr.27.061406.093734
    [Google Scholar]
  21. Alam G. Bali S. Preliminary phytochemical and antimicrobial screening of leaves extract of Acacia catechu. J. Pharm. Res. 2010 3 2583 2584
    [Google Scholar]
  22. Sarker U. Oba S. Polyphenol and flavonoid profiles and radical scavenging activity in leafy vegetable Amaranthus gangeticus. BMC Plant Biol. 2020 20 1 499 10.1186/s12870‑020‑02700‑0 33138787
    [Google Scholar]
  23. Rao P.K. Hasan S.S. Bhellum B.L. Manhas R.K. Ethnomedicinal plants of Kathua district, J&K, India. J. Ethnopharmacol. 2015 171 12 27 10.1016/j.jep.2015.05.028 26023030
    [Google Scholar]
  24. Benavente-García O. Castillo J. Update on uses and properties of citrus flavonoids: New findings in anticancer, cardiovascular, and anti-inflammatory activity. J. Agric. Food Chem. 2008 56 15 6185 6205 10.1021/jf8006568 18593176
    [Google Scholar]
  25. Dewangan D. Nakhate K. Mishra A. Thakur A.S. Rajak H. Dwivedi J. Sharma S. Paliwal S. Design, synthesis, and characterization of Quinoxaline derivatives as a potent Antimicrobial agent. J. Heterocycl. Chem. 2019 56 2 566 578 10.1002/jhet.3431
    [Google Scholar]
  26. Alami Merrouni I. Elachouri M. Anticancer medicinal plants used by Moroccan people: Ethnobotanical, preclinical, phytochemical and clinical evidence. J. Ethnopharmacol. 2021 266 113435 10.1016/j.jep.2020.113435 33022340
    [Google Scholar]
  27. Ezhil I. Lakshmi T. Antibacterial efficacy of epicatechin and rutin from Acacia catechu leaf extract against Enterococcus faecalis and Streptococcus mutans - An in vitro study. J. Adv. Pharm. Educ. Res. 2017 7 22 24
    [Google Scholar]
  28. Negi B.S. Dave B.P. In vitro antimicrobial activity of Acacia catechu and Its phytochemical analysis. Indian J. Microbiol. 2010 50 4 369 374 10.1007/s12088‑011‑0061‑1 22282602
    [Google Scholar]
  29. Portenier I. Waltimo T.M.T. Haapasalo M. Enterococcus faecalis – The root canal survivor and ‘star’ in post‐treatment disease. Endod. Topics 2003 6 1 135 159 10.1111/j.1601‑1546.2003.00040.x
    [Google Scholar]
  30. Kumar P. Ansari S.H. Ali J. Herbal remedies for the treatment of periodontal disease--A patent review. Recent Pat. Drug Deliv. Formul. 2009 3 3 221 228 10.2174/187221109789105603 19925444
    [Google Scholar]
  31. Patel J.D. Kumar V. Bhatt S.A. Antimicrobial screening and phytochemical analysis of the resin part of Acacia catechu. Pharm. Biol. 2009 47 1 34 37 10.1080/13880200802400527
    [Google Scholar]
  32. Micucci M. Gotti R. Corazza I. Tocci G. Chiarini A. De Giorgio M. Camarda L. Frosini M. Marzetti C. Cevenini M. Budriesi R. Newer insights into the antidiarrheal effects of Acacia catechu willd. Extract in guinea pig J. Med. Food 2017 20 6 592 600 10.1089/jmf.2016.0154
    [Google Scholar]
  33. Singh M. Raj V. Rai A. Detection of bioflavonoids from methanol bark extracts of Acacia and their role as Antidiarrhoeal agents. J. Anal. Pharm. Res. 2017 5 4 1 6 10.15406/japlr.2017.05.00146
    [Google Scholar]
  34. Lee C.W. Ahn Y.T. Zhao R. Kim Y.S. Park S.M. Jung D.H. Kim J.K. Kim H.W. Kim S.C. An W.G. Inhibitory effects of Porphyra tenera extract on oxidation and inflammatory responses. Evid. Based Complement. Alternat. Med. 2021 2021 6650037 10.1155/2021/6650037 33868441
    [Google Scholar]
  35. Maheshwari M. Maheshwari R.K. Fabulous therapeutic benefits of multipurpose Katechu/Kattha (Acacia catechu linn. f. willd) IJMRD 2022 9 4 68 72
    [Google Scholar]
  36. Burnett B.P. Jia Q. Zhao Y. Levy R.M. Chen S. A medicinal extract of Scutellaria baicalensis and Acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation. J. Med. Food 2007 10 3 442 451 10.1089/jmf.2006.255 17887937
    [Google Scholar]
  37. Bitto A. Squadrito F. Irrera N. Pizzino G. Pallio G. Mecchio A. Galfo F. Altavilla D. Flavocoxid, a nutraceutical approach to blunt inflammatory conditions. Mediators Inflamm. 2014 2014 790851 10.1155/2014/790851 25242871
    [Google Scholar]
  38. Yimam M. Horm T. O’Neal A. Jiao P. Hong M. Brownell L. Jia Q. Lin M. Gauthier A. Wu J. Mateti K.V. Yang X. Dial K. Zefi S. Mantell L.L. A standardized botanical composition mitigated acute inflammatory lung injury and reduced mortality through extracellular HMGB1 reduction Molecules 2023 28 18 6560 10.3390/molecules28186560
    [Google Scholar]
  39. Nutan S.K. Modi M. Dezzutti C.S. Kulshreshtha S. Rawat A.K.S. Srivastava S.K. Malhotra S. Verma A. Ranga U. Gupta S.K. Extracts from Acacia catechu suppress HIV-1 replication by inhibiting the activities of the viral protease and Tat. Virol. J. 2013 10 1 309 10.1186/1743‑422X‑10‑309 25228267
    [Google Scholar]
  40. Panya A. Yongpitakwattana P. Budchart P. Sawasdee N. Krobthong S. Paemanee A. Roytrakul S. Rattanabunyong S. Choowongkomon K. Yenchitsomanus P.T. Novel bioactive peptides demonstrating anti-dengue virus activity isolated from the Asian medicinal plant Acacia Catechu. Chem. Biol. Drug Des. 2019 93 2 100 109 10.1111/cbdd.13400 30225997
    [Google Scholar]
  41. Patil A. Modak M. Comparative evaluation of oxidative stress modulating and DNA protective activities of aqueous and Methanolic extracts of Acacia catechu Medicines (Basel) 2017 4 3 65 10.3390/medicines4030065
    [Google Scholar]
  42. Aryal B. Adhikari B. Aryal N. Bhattarai B.R. Khadayat K. Parajuli N. LC-HRMS profiling and Antidiabetic, antioxidant, and antibacterial activities of Acacia catechu (L.f.) willd. BioMed Res. Int. 2021 2021 7588711 10.1155/2021/7588711 34435049
    [Google Scholar]
  43. Lakshmi T. Ezhilarasan D. Vijayaragavan R. Bhullar S.K. Rajendran R. Acacia catechu ethanolic bark extract induces apoptosis in human oral squamous carcinoma cells. J. Adv. Pharm. Technol. Res. 2017 8 4 143 149 10.4103/japtr.JAPTR_73_17 29184846
    [Google Scholar]
  44. Mir H. Elieh Ali Komi D. Pouramir M. Parsian H. Moghadamnia A.A. Seyfizadeh N. Lakzaei M. The hepatoprotective effects of Pyrus biossieriana buhse leaf extract on tert-butyl hydroperoxide toxicity in HepG2 cell line. BMC Res. Notes 2021 14 1 298 10.1186/s13104‑021‑05713‑6 34344447
    [Google Scholar]
  45. Lakshmi T. Sri Renukadevi B. Senthilkumar S. Haribalan P. Parameshwari R. Vijayaraghavan R. Rajeshkumar S. Seed and bark extracts of Acacia catechu protects liver from acetaminophen induced hepatotoxicity by modulating oxidative stress, antioxidant enzymes and liver function enzymes in Wistar rat model. Biomed. Pharmacother. 2018 108 838 844 10.1016/j.biopha.2018.08.077 30372895
    [Google Scholar]
  46. Adhikari B. Aryal B. Bhattarai B.R. A comprehensive review on the chemical composition and pharmacological activities of Acacia catechu (L.f.) willd. J. Chem. 2021 2021 1 11 10.1155/2021/2575598
    [Google Scholar]
  47. Ghate N.B. Hazra B. Sarkar R. Mandal N. Heartwood extract of Acacia catechu induces apoptosis in human breast carcinoma by altering bax/bcl-2 ratio. Pharmacogn. Mag. 2014 10 37 27 33 10.4103/0973‑1296.126654 24695415
    [Google Scholar]
  48. Monga J. Chauhan C.S. Sharma M. Human breast adenocarcinoma cytotoxicity and modulation of 7,12-dimethylbenz[a]anthracene-induced mammary carcinoma in Balb/c mice by Acacia catechu (L.f.) Wild heartwood. Integr. Cancer Ther. 2013 12 4 347 362 10.1177/1534735412463818 23142797
    [Google Scholar]
  49. Diab K.A.E. Guru S.K. Bhushan S. Saxena A.K. In vitro anticancer activities of Anogeissus latifolia, Terminalia bellerica, Acacia catechu and Moringa oleiferna Indian plants. Asian Pac. J. Cancer Prev. 2015 16 15 6423 6428 10.7314/APJCP.2015.16.15.6423 26434854
    [Google Scholar]
  50. Aryal B. Niraula P. Khadayat K. Adhikari B. Khatri Chhetri D. Sapkota B.K. Bhattarai B.R. Aryal N. Parajuli N. Antidiabetic, antimicrobial, and molecular profiling of selected medicinal plants. Evid. Based Complement. Alternat. Med. 2021 2021 5510099 10.1155/2021/5510099 34040646
    [Google Scholar]
  51. Srivastava S.P. Mishra A. Bhatia V. Narender T. Srivastava A.K. Acacia catechu hard wood: potential anti-diabetic cum anti-dyslipidemic. Med. Chem. Res. 2011 20 9 1732 1739 10.1007/s00044‑010‑9479‑y
    [Google Scholar]
  52. Rajendra P. Anticuler activity of Acacia catechu wild in rats. IJRAP 2011 2 5 1585 1587
    [Google Scholar]
  53. Bhardwaj P. Shailendra K. Sharma D.S. Sharma A. Kulkarni M.P. Singh S.K. Singh V.P. Singh G. Kumar P. Kumar R. Chewable tablets of Acacia catechu extract, an alternative to Betel (Paan) for mouth ulcers: Formulation and in vitro evaluation. Curr. Drug Deliv. 2021 18 4 500 512 10.2174/1567201817999200728140352 32723271
    [Google Scholar]
  54. Jain S. Singh R. Paliwal S. Sharma S. Targeting neuroinflammation as disease modifying approach to alzheimer’s disease: Potential and challenges. Mini Rev. Med. Chem. 2023 23 22 2097 2116 10.2174/1389557523666230511122435 37170998
    [Google Scholar]
  55. Jarald E. Joshi S.B. Jain D.C. Biochemical study on the hypoglycaemic effects of extract and fraction of Acacia catechu willd in alloxan-induced diabetic rats. Int. J. Diabetes Metab. 2009 17 63 69 10.1159/000497675
    [Google Scholar]
  56. Vz S. Jk K. Pm N. Mp N. G O. Em N. S. VZ Antipyretic, Antiinflammatory and Antinociceptive Activities of Aqueous Bark Extract of Acacia Nilotica (L.) Delile in Albino Mice. Journal of Pain Management & Medicine 2016 2 2 10.35248/2684‑1320.16.2.113
    [Google Scholar]
  57. Atmani D. Chaher N. Atmani D. Berboucha M. Debbache N. Boudaoud H. Flavonoids in human health: From structure to biological activity. Curr. Nutr. Food Sci. 2009 5 4 225 237 10.2174/157340109790218049
    [Google Scholar]
  58. Jain S. Bisht A. Verma K. Negi S. Paliwal S. Sharma S. The role of fatty acid amide hydrolase enzyme inhibitors in alzheimer’s disease. Cell Biochem. Funct. 2021 10.1002/cbf.3680 34931308
    [Google Scholar]
  59. Saithi C. Pashikanti G. Singh A. Wound healing potential of some medicinal plants. Int. J. Pharm. Sci. Rev. Res. 2022 9 106 116 10.47583/ijpsrr.2022.v77i01.017
    [Google Scholar]
  60. Pingale S.S. Hepatoprotection by Acacia catechu in CCl4 induced liver dysfunction. Int. J. Pharm. Sci. Rev. Res. 2010 5 150 154
    [Google Scholar]
  61. Lakshmi T. Geetha R.V. Roy A. In vitro evaluation of antibacterial activity of heartwood extract of Acacia catechu willd. Int. J. Pharma Bio Sci. 2011 2 188 192
    [Google Scholar]
  62. Patil S. Deshmukh P. Sreenivas S.A. Sangameshwar K. Vijapur L. In vitro anthelmintic activity of Acacia catechu willd. International Journal of Green Pharmacy 2013 7 1 34 36 10.4103/0973‑8258.111605
    [Google Scholar]
  63. Batiha G.E.S. Akhtar N. Alsayegh A.A. Abusudah W.F. Almohmadi N.H. Shaheen H.M. Singh T.G. De Waard M. Bioactive compounds, pharmacological actions, and pharmacokinetics of genus Acacia. Molecules 2022 27 21 7340 10.3390/molecules27217340 36364163
    [Google Scholar]
  64. Jain S. Sharma S. Paliwal A. Dwivedi J. Paliwal S. Paliwal V. Paliwal S. Sharma J. Discovery of novel fatty acid amide hydrolase (FAAH) inhibitors as anti-alzheimer’s agents through pharmacophore-based virtual screening, molecular docking and experimental validation. Med. Chem. Res. 2023 ••• 1 15 10.1007/S00044‑023‑03170‑3/FIGURES/10
    [Google Scholar]
  65. Thangavelu L. Vijayaragavan R. Selvanadhan P. Ezhilarasan D. Acute oral toxicity study of ethanolic extract of acacia catechu willd. Seed using hematological and biochemical parameters in wistar albino rat. Toxicol. Int. 2015 22 2 58 64 10.22506/ti/2015/v22/i2/137657
    [Google Scholar]
  66. T Lakshmi. Invitro cytotoxicity assay of acacia catechu ethanolic seed extract using brine shrimp JCMR 2020 11 5
    [Google Scholar]
  67. Hemashree J. Thangavelu L. Anti-Inflammatory action of Acacia Catechu seed extract JAPER 2018 8 3 92 95
    [Google Scholar]
  68. Nakhate V.P. Akojwar N.S. Sinha S.K. Lomte A.D. Dhobi M. Itankar P.R. Prasad S.K. Wound healing potential of Acacia catechu in streptozotocin-induced diabetic mice using in vivo and in silico approach. J. Tradit. Complement. Med. 2023 13 5 489 499 10.1016/j.jtcme.2023.05.001 37693096
    [Google Scholar]
  69. Ashfaq M. And A. Thangavelu L. ANTIFUNGAL ACTIVITY OF Acacia catechu SEED EXTRACT- AN in vitro STUDY PLANT CELL Biotechnol. Mol. Biol. 2020 21 46 51
    [Google Scholar]
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