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image of Polyphenolics Profile of Casimiora edulis Llave. and Evaluation of its Hepatoprotective Potential

Abstract

Background

Paracetamol overdose can lead to severe liver damage due to the formation of toxic metabolites. , rich in polyphenols and flavonoids, and silymarin, a known liver protectant, may help mitigate this damage.

Objective

This study aims to characterize the main phytoconstituents of leaves and evaluate their hepatoprotective activity.

Methods

Leaves of were extracted with methanol. The total flavonoid and phenolic acid contents in the methanol extract were identified using HPLC. The hepatoprotective effects were assessed in 30 mice divided into five groups, treated with paracetamol to induce liver damage, and administered extract or silymarin at different doses. Blood and liver samples were collected to measure biochemical markers, oxidative stress indicators, inflammatory markers, and gene expression. Histopathological examination of liver tissues was also performed.

Results

HPLC analysis revealed a rich polyphenolic profile, with gallic acid (1905.83 µg/g) and diadzein (7039.18 µg/g) as predominant compounds. Paracetamol administration significantly increased TC, TG, liver enzyme levels (ALT, AST, LDH, ALP), MDA, IL-6, TNF-α, and CYP2E1, while decreasing HDL-c, SOD, GSH, and CAT levels, as well as BcL-2 and P53 gene expression, indicating hepatotoxicity. Treatment with extract and silymarin significantly mitigated these adverse effects, improving plasma lipid profiles, liver enzyme levels, oxidative stress biomarkers, inflammatory mediators, and gene expression. In addition, extract and silymarin significantly improve liver histopathological scores in paracetamol-treated mice. Despite severe congestion and necrosis, the liver maintained its typical structure with central veins and hepatocyte cords, highlighting the potential therapeutic benefits of these treatments.

Conclusion

extract and silymarin demonstrate significant hepatoprotective effects against paracetamol-induced liver damage. Their rich polyphenolic and flavonoid content effectively mitigates oxidative stress and inflammation, improving biochemical markers and preserving liver structure. These findings highlight their potential as therapeutic agents for liver health.

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2025-02-28
2025-04-21

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References

  1. Khalil O.S.F. Ismail H.A. Elkot W.F. Physicochemical, functional and sensory properties of probiotic yoghurt flavored with white sapote fruit (Casimiroa edulis). J. Food Sci. Technol. 2022 59 9 3700 3710 10.1007/s13197‑022‑05393‑5 35875242
    [Google Scholar]
  2. Moo-Huchin V.M. Moo-Huchin M.I. Estrada-León R.J. Cuevas-Glory L. Estrada-Mota I.A. Ortiz-Vázquez E. Betancur-Ancona D. Sauri-Duch E. Antioxidant compounds, antioxidant activity and phenolic content in peel from three tropical fruits from Yucatan, Mexico. Food Chem. 2015 166 17 22 10.1016/j.foodchem.2014.05.127 25053022
    [Google Scholar]
  3. Moo-Huchin V.M. Estrada-Mota I. Estrada-León R. Cuevas-Glory L. Ortiz-Vázquez E. Vargas M.L.V. Betancur-Ancona D. Sauri-Duch E. Determination of some physicochemical characteristics, bioactive compounds and antioxidant activity of tropical fruits from Yucatan, Mexico. Food Chem. 2014 152 508 515 10.1016/j.foodchem.2013.12.013 24444968
    [Google Scholar]
  4. Duraipandiyan V. Ayyanar M. Ignacimuthu S. Antimicrobial activity of some ethnomedicinal plants used by Paliyar tribe from Tamil Nadu, India. BMC Complement. Altern. Med. 2006 6 1 35 10.1186/1472‑6882‑6‑35 17042964
    [Google Scholar]
  5. Phua D.H. Zosel A. Heard K. Dietary supplements and herbal medicine toxicities—when to anticipate them and how to manage them. Int. J. Emerg. Med. 2009 2 2 69 76 10.1007/s12245‑009‑0105‑z 20157447
    [Google Scholar]
  6. Bernardini S. Tiezzi A. Laghezza Masci V. Ovidi E. Natural products for human health: An historical overview of the drug discovery approaches. Nat. Prod. Res. 2018 32 16 1926 1950 10.1080/14786419.2017.1356838 28748726
    [Google Scholar]
  7. Pandey K.B. Rizvi S.I. Plant polyphenols as dietary antioxidants in human health and disease. Oxid. Med. Cell. Longev. 2009 2 5 270 278 10.4161/oxim.2.5.9498 20716914
    [Google Scholar]
  8. Manach C. Scalbert A. Morand C. Rémésy C. Jiménez L. Polyphenols: Food sources and bioavailability. Am. J. Clin. Nutr. 2004 79 5 727 747 10.1093/ajcn/79.5.727 15113710
    [Google Scholar]
  9. Elkot W.F. El-Sawah T.H. Mohamed Abdeldaiem A. Alnuzaili E.S. AbdelRasool Abdelsamad Eljeam H. AL-Farga A. Elmahdy A. Effect of using dried white sapote fruit (Casimiroa edulis) on the quality characteristics of bio-low-fat goat milk yoghurt drink. Saudi J. Biol. Sci. 2023 30 12 103844 10.1016/j.sjbs.2023.103844 38073662
    [Google Scholar]
  10. Nagai H. Tanaka T. Goto T. Kusudo T. Takahashi N. Kawada T. Phenolic compounds from leaves of Casimiroa edulis showed adipogenesis activity. Biosci. Biotechnol. Biochem. 2014 78 2 296 300 10.1080/09168451.2014.877821 25036684
    [Google Scholar]
  11. Elkady W.M. Ibrahim E.A. Gonaid M.H. El Baz F.K. Chemical profile and biological activity of Casimiroa Edulis non-edible fruit’s parts. Adv. Pharm. Bull. 2017 7 4 655 660 10.15171/apb.2017.079 29399557
    [Google Scholar]
  12. Kim R.O. Jo M.A. Song J. Kim I.C. Yoon S. Kim W.K. Novel approach for evaluating pharmaceuticals toxicity using Daphnia model: Analysis of the mode of cytochrome P450-generated metabolite action after acetaminophen exposure. Aquat. Toxicol. 2018 196 35 42 10.1016/j.aquatox.2017.12.017 29328974
    [Google Scholar]
  13. El Gizawy H.A. Abo-Salem H.M. Ali A.A. Hussein M.A. Hussein M.A. Phenolic profiling and therapeutic potential of certain isolated compounds from Parkia roxburghii against AChE activity as well as GABA A α5, GSK-3β, and p38α MAP-Kinase genes. ACS Omega 2021 6 31 20492 20511 10.1021/acsomega.1c02340 34395996
    [Google Scholar]
  14. Hussein M.A. Prophylactic effect of resveratrol against ethinylestradiol-induced liver cholestasis. J. Med. Food 2013 16 3 246 254 10.1089/jmf.2012.0183 23305807
    [Google Scholar]
  15. Athersuch T.J. Antoine D.J. Boobis A.R. Coen M. Daly A.K. Possamai L. Nicholson J.K. Wilson I.D. Paracetamol metabolism, hepatotoxicity, biomarkers and therapeutic interventions: A perspective. Toxicol. Res. 2018 7 3 347 357 10.1039/c7tx00340d 30090586
    [Google Scholar]
  16. Mohammed Abdalla H. Jr Soad Mohamed A.G. In vivo Hepato-protective properties of purslane extracts on paracetamol-induced liver damage. Malays. J. Nutr. 2010 16 1 161 170 22691863
    [Google Scholar]
  17. Şahin S. Aydın A.Ç. Göçmen A.Y. Kaymak E. Evaluation of the protective effect of losartan in acetaminophen-induced liver and kidney damage in mice. Naunyn Schmiedebergs Arch. Pharmacol. 2024 397 7 5067 5078 10.1007/s00210‑023‑02937‑0 38194107
    [Google Scholar]
  18. Boshra S.A. Hussein M.A. Cranberry extract as a supplemented food in treatment of oxidative stress and breast cancer induced by N-Methyl-N-Nitrosourea in female virgin rats. Int. J. Phytomed. 2016 8 217 227 10.5138/09750185.1907
    [Google Scholar]
  19. El-Gizawy H.A. Hussein M.A. Fatty acids profile, nutritional values, anti-diabetic and antioxidant activity of the fixed oil of malvaparviflora growing in Egypt. Int. J. Phytomed. 2015 7 219 230 10.5138/09750185.1848
    [Google Scholar]
  20. M Fayed A. A Abdalla E. Hassan S.A. A Hussein M. M Roshdy T. Downregulation of TLR4-NF-?B-p38 MAPK signalling in cholestatic rats treated with cranberry extract. Pak. J. Biol. Sci. 2022 25 2 112 122 10.3923/pjbs.2022.112.122 35233999
    [Google Scholar]
  21. Elmoghazy H.M. Hussein M.A. Abdel-Aziz A. Elmasry S.A. Metwal A.M. CAPE improves Vanin-1/AKT/miRNA-203 signaling pathways in DSS-induced ulcerative Colitis. Biomed. Res. Ther. 2022 9 9 5313 5325 10.15419/bmrat.v9i9.769
    [Google Scholar]
  22. Koheil M.A. Hussein M.A. Othman S.M. El-Haddad A. Anti-inflammatory and antioxidant activities of Moringa peregrina Seeds. Free Radic. Antioxid. 2011 1 2 49 61 10.5530/ax.2011.2.10
    [Google Scholar]
  23. Elneklawi M.S. Mohamed Z.N. Hussein M.A. Mohamad E.A. STEN ameliorates VEGF gene expression by improving XBP1/mRNA-21/mRNA-330 signalling pathways in cisplatin-induced uterus injury in rats. J. Drug Deliv. Sci. Technol. 2023 87 104760 10.1016/j.jddst.2023.104760
    [Google Scholar]
  24. Alamir M. Hussein M.A. Aboud H.M. Khedr M.H. Zanaty M.I. Optimization of phloretin-loaded nanospanlastics for targeting of FAS/SREBP1c/AMPK/ OB-Rb signaling pathway in HFD-induced obesity. Curr. Pharm. Biotechnol. 2025 26 1 92 107 10.2174/0113892010278684240105115516 38698746
    [Google Scholar]
  25. Mansour M.S. Mahmoud A.A. Sayah M.A. Mohamed Z.N. Hussein M.A. ALsherif D.A. RES-CMCNPs enhance antioxidant, proinflammatory, and sensitivity of tumor solids to γ-irradiation in EAC-bearing mice. Pharm. Nanotechnol. 2025 13 1 254 269 10.2174/0122117385290497240324190453 38676484
    [Google Scholar]
  26. Ibrahim El-belbasy H. Abdalla Hussein M. El-mitwaly Alghitany M. Potential effects of cranberry extract against lead acetate-induced hepato-renal toxicity in rats. Adv. Anim. Vet. Sci. 2021 9 10 1669 1683 10.17582/journal.aavs/2021/9.10.1669.1683
    [Google Scholar]
  27. Awaad A.S. El-Sayed N.H. Maitland D.J. Mabry T.J. Phenolic antioxidants from Casimiroa edulis. leaves. Pharm. Biol. 2006 44 4 258 262 10.1080/13880200600713899
    [Google Scholar]
  28. Garzón-De la Mora P. García-López P.M. García-Estrada J. Navarro-Ruíz A. Villanueva-Michel T. Villarreal-de Puga L.M. Casillas-Ochoa J. Casimiroa edulis seed extracts show anticonvulsive properties in rats. J. Ethnopharmacol. 1999 68 1-3 275 282 10.1016/S0378‑8741(99)00125‑7 10624888
    [Google Scholar]
  29. Teksoy O. Sahinturk V. Cengiz M. İnal B. Ayhancı A. The Protective Effects of Silymarin on Thioacetamide-Induced Liver Damage: Measurement of miR-122, miR-192, and miR-194 Levels. Appl. Biochem. Biotechnol. 2020 191 2 528 539 10.1007/s12010‑019‑03177‑w 31811641
    [Google Scholar]
  30. Fossati P. Prencipe L. Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clin. Chem. 1982 28 10 2077 2080 10.1093/clinchem/28.10.2077 6812986
    [Google Scholar]
  31. Allain C.C. Poon L.S. Chan C.S.G. Richmond W. Fu P.C. Enzymatic determination of total serum cholesterol. Clin. Chem. 1974 20 4 470 475 10.1093/clinchem/20.4.470 4818200
    [Google Scholar]
  32. Burstein M. Scholnick H.R. Morfin R. Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. J. Lipid Res. 1970 11 6 583 595 10.1016/S0022‑2275(20)42943‑8 4100998
    [Google Scholar]
  33. Reitman S. Frankel S. A colorimetric method for the determination of plasma oxaloacetic acid and glutamic pyruvic transaminases. Am. J. Clin. Pathol. 1957 28 56 63 10.1093/ajcp/28.1.56 13458125
    [Google Scholar]
  34. Kind P.R.N. King E.J. Estimation of plasma phosphatase by determination of hydrolysed phenol with amino-antipyrine. J. Clin. Pathol. 1954 7 4 322 326 10.1136/jcp.7.4.322 13286357
    [Google Scholar]
  35. Buhl S.N. Jackson K.Y. Optimal conditions and comparison of lactate dehydrogenase catalysis of the lactate to pyruvate to lactate reactions in human plasma at 25, 30, and 37 oC. Clin. Chem. 1978 2415 828 10.1093/clinchem/24.5.828 25724
    [Google Scholar]
  36. Swift D.L. Johannsen N.M. Earnest C.P. Blair S.N. Church T.S. Effect of different doses of aerobic exercise training on total bilirubin levels. Med. Sci. Sports Exerc. 2012 44 4 569 574 10.1249/MSS.0b013e3182357dd4 21900842
    [Google Scholar]
  37. Owen J.B. Butterfield D.A. Measurement of oxidized/reduced glutathione ratio. Methods Mol. Biol. 2010 648 269 277 10.1007/978‑1‑60761‑756‑3_18 20700719
    [Google Scholar]
  38. Uchiyama M. Mihara M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal. Biochem. 1978 86 1 271 278 10.1016/0003‑2697(78)90342‑1 655387
    [Google Scholar]
  39. Marklund S. Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem. 1974 47 3 469 474 10.1111/j.1432‑1033.1974.tb03714.x 4215654
    [Google Scholar]
  40. Glorieux C Zamocky M Sandoval JM Verrax J Calderon PB Regulation of catalase expression in healthy and cancerous cells. Free Radic Biol Med. 2015 87 84 97 10.1016/j.freeradbiomed.2015.06.017
    [Google Scholar]
  41. Carleton H.M. Drury R.A.B. Carleton’s Histological Technique. Oxford University Press New York 1980 1 200
    [Google Scholar]
  42. Chroho M. Aazza M. Bouymajane A. Majdoub Y.O.E. Cacciola F. Mondello L. Zair T. Bouissane L. HPLC-PDA/ESI-MS analysis of phenolic compounds and bioactivities of the ethanolic extract from flowers of Moroccan Anacyclus clavatus. Plants 2022 11 24 3423 10.3390/plants11243423 36559535
    [Google Scholar]
  43. Seal T. Quantitative HPLC analysis of phenolic acids, flavonoids and ascorbic acid in four different solvent extracts of two wild edible leaves, Sonchus arvensis and Oenanthe linearis of North-Eastern region in India. J. Appl. Pharm. Sci. 2016 6 02 157 166 10.7324/JAPS.2016.60225
    [Google Scholar]
  44. Fanta Yadang S.A. Taiwe Sotoing G. Ngatcha Zouakeu K.S. Khan M.A. Agbor G.A. Ur-Rahman N. Ngo Bum E. Quantification of bioactive compounds and evaluation of the antioxidant activity of Carissa edulis Valh (Apocynaceae) leaves. ScientificWorldJournal 2019 2019 1 9 10.1155/2019/7549620 31223295
    [Google Scholar]
  45. Ralapanawa U. Jayawickreme K.P. Ekanayake E.M.M. Dissanayake A.M.S.D.M. A study on paracetamol cardiotoxicity. BMC Pharmacol. Toxicol. 2016 17 1 30 10.1186/s40360‑016‑0073‑x 27411502
    [Google Scholar]
  46. Erfanian S.S. Ansari H. Javanmard S.H. Amini Z. Hajigholami A. The hepatorenal protective effects of silymarin in cancer patients receiving chemotherapy: A randomized, placebo-controlled trial. BMC Complement. Med. Ther. 2024 24 1 329 10.1186/s12906‑024‑04627‑7 39232773
    [Google Scholar]
  47. Shimizu K. Nishimuta S. Fukumura Y. Michinaga S. Egusa Y. Hase T. Terada T. Sakurai F. Mizuguchi H. Tomita K. Nishinaka T. Liver-specific overexpression of lipoprotein lipase improves glucose metabolism in high-fat diet-fed mice. PLoS One 2022 17 9 e0274297 10.1371/journal.pone.0274297 36099304
    [Google Scholar]
  48. Naeini F. Namkhah Z. Tutunchi H. Rezayat S.M. Mansouri S. Jazayeri-Tehrani S.A. Yaseri M. Hosseinzadeh-Attar M.J. Effects of naringenin supplementation in overweight/obese patients with non-alcoholic fatty liver disease: Study protocol for a randomized double-blind clinical trial. Trials 2021 22 1 801 10.1186/s13063‑021‑05784‑7 34774104
    [Google Scholar]
  49. Mu H. Zhou Q. Yang R. Zeng J. Li X. Zhang R. Tang W. Li H. Wang S. Shen T. Huang X. Dou L. Dong J. Naringin Attenuates high fat diet induced non-alcoholic fatty liver disease and gut bacterial dysbiosis in mice. Front. Microbiol. 2020 11 585066 10.3389/fmicb.2020.585066 33281780
    [Google Scholar]
  50. Yang D. Qiu Q. Xu L. Xu Y. Wang Y. The complete chloroplast genome sequence of Casimiroa edulis. Mitochondrial DNA B Resour. 2019 4 2 3979 3980 10.1080/23802359.2019.1688711 33366279
    [Google Scholar]
  51. Corona L.R.D. Rodríguez M.E.M. Pérez L.M.A. Yerena A.R. Martínez Preciado A.H. Reyes-Becerril M. Immunostimulant effects of diet supplementation with yellow (Pouteria campechiana), white (Casimiroa edulis), and black (Diospyros digyna) sapote nanocapsules on laying hens: In vitro and in vivo study. Trop. Anim. Health Prod. 2023 55 6 360 10.1007/s11250‑023‑03778‑y 37851183
    [Google Scholar]
  52. Rouf R. Ghosh P. Uzzaman M.R. Sarker D.K. Zahura F.T. Uddin S.J. Muhammad I. Hepatoprotective plants from Bangladesh: A biophytochemical review and future prospect. Evid. Based Complement. Alternat. Med. 2021 2021 1 39 10.1155/2021/1633231 34504532
    [Google Scholar]
  53. Zhang J. Zhang W. Yang L. Zhao W. Liu Z. Wang E. Wang J. Phytochemical gallic acid alleviates nonalcoholic fatty liver disease via AMPK-ACC-PPARa axis through dual regulation of lipid metabolism and mitochondrial function. Phytomedicine 2023 109 154589 10.1016/j.phymed.2022.154589 36610145
    [Google Scholar]
  54. Zeng Y. Wu R. Wang F. Li S. Li L. Li Y. Qin P. Wei M. Yang J. Wu J. Chen A. Ke G. Yan Z. Yang H. Chen Z. Wang Z. Xiao W. Jiang Y. Chen X. Zeng Z. Zhao X. Chen P. Gong S. Liberation of daidzein by gut microbial β-galactosidase suppresses acetaminophen-induced hepatotoxicity in mice. Cell Host Microbe 2023 31 5 766 780.e7 10.1016/j.chom.2023.04.002 37100057
    [Google Scholar]
  55. Yin T. Yue X. Li Q. Zhou X. Dong R. Chen J. Zhang R. Wang X. He S. Jiang T. Tao F. Cao Y. Ji D. Liang C. The association between the levels of oxidative stress indicators (MDA, SOD, and GSH) in Seminal plasma and the risk of Idiopathic Oligo-asthenotera-tozoospermia: Does Cu or Se level alter the association? Biol. Trace Elem. Res. 2024 202 7 2941 2953 10.1007/s12011‑023‑03888‑6 37803189
    [Google Scholar]
  56. Wadhwa K. Pahwa R. Kumar M. Kumar S. Sharma P.C. Singh G. Verma R. Mittal V. Singh I. Kaushik D. Jeandet P. Mechanistic insights into the pharmacological significance of Silymarin. Molecules 2022 27 16 5327 10.3390/molecules27165327 36014565
    [Google Scholar]
  57. Guo J.T. Li H.Y. Cheng C. Shi J.X. Ruan H.N. Li J. Liu C.M. Isochlorogenic acid A ameliorated lead-induced anxiety-like behaviors in mice by inhibiting ferroptosis-mediated neuroinflammation via the BDNF/Nrf2/GPX4 pathways. Food Chem. Toxicol. 2024 190 114814 10.1016/j.fct.2024.114814 38876379
    [Google Scholar]
  58. Shabbir M. Afsar T. Razak S. Almajwal A. Khan M.R. Phytochemical analysis and Evaluation of hepatoprotective effect of Maytenus royleanus leaves extract against anti-tuberculosis drug induced liver injury in mice. Lipids Health Dis. 2020 19 1 46 10.1186/s12944‑020‑01231‑9 32178678
    [Google Scholar]
  59. Bahari H. Shahraki Jazinaki M. Rashidmayvan M. Taheri S. Amini M.R. Malekahmadi M. The effects of silymarin consumption on inflammation and oxidative stress in adults: A systematic review and meta-analysis. Inflammopharmacology 2024 32 2 949 963 10.1007/s10787‑023‑01423‑6 38372848
    [Google Scholar]
  60. Lenoir C. Rollason V. Desmeules J.A. Samer C.F. Influence of inflammation on Cytochromes P450 activity in adults: A systematic review of the literature. Front. Pharmacol. 2021 12 733935 10.3389/fphar.2021.733935 34867341
    [Google Scholar]
  61. Islam M.T. Quispe C. Islam M.A. Ali E.S. Saha S. Asha U.H. Mondal M. Razis A.F.A. Sunusi U. Kamal R.M. Kumar M. Sharifi-Rad J. Effects of nerol on paracetamol-induced liver damage in Wistar albino rats. Biomed. Pharmacother. 2021 140 111732 10.1016/j.biopha.2021.111732 34130201
    [Google Scholar]
  62. Yan SL Wang ZH Yen HF Lee YJ Yin MC Reversal of ethanol-induced hepatotoxicity by cinnamic and syringic acids in mice. Food Chem Toxicol. 2016 98 Pt B 119 126 10.1016/j.fct.2016.10.025
    [Google Scholar]
  63. Chen L. Liu L. Abdulla R. Tursun X. Xin X. Aisa H.A. Chemical components and hepatoprotective mechanism of Xwak Granule in mice treated with acute alcohol. Evid. Based Complement. Alternat. Med. 2020 2020 1 8538474 10.1155/2020/8538474 33062026
    [Google Scholar]
  64. El-Hassan H. Anwar K. Macanas-Pirard P. Crabtree M. Chow S.C. Johnson V.L. Lee P.C. Hinton R.H. Price S.C. Kass G.E.N. Involvement of mitochondria in acetaminophen-induced apoptosis and hepatic injury. Toxicol. Appl. Pharmacol. 2003 191 2 118 129 10.1016/S0041‑008X(03)00240‑0 12946648
    [Google Scholar]
  65. El-Bakry H.A. El-Sherif G. Rostom R.M. Therapeutic dose of green tea extract provokes liver damage and exacerbates paracetamol-induced hepatotoxicity in rats through oxidative stress and caspase 3-dependent apoptosis. Biomed. Pharmacother. 2017 96 798 811 10.1016/j.biopha.2017.10.055 29078257
    [Google Scholar]
  66. Alam M. Alam S. Shamsi A. Adnan M. Elasbali A.M. Al-Soud W.A. Alreshidi M. Hawsawi Y.M. Tippana A. Pasupuleti V.R. Hassan M.I. Bax/Bcl-2 cascade is regulated by the EGFR pathway: Therapeutic targeting of non-small cell lung cancer. Front. Oncol. 2022 12 869672 10.3389/fonc.2022.869672 35402265
    [Google Scholar]
  67. Fan X. Chen P. Tan H. Zeng H. Jiang Y. Wang Y. Wang Y. Hou X. Bi H. Huang M. Dynamic and coordinated regulation of KEAP1-NRF2-ARE and p53/p21 signaling pathways is associated with acetaminophen injury responsive liver regeneration. Drug Metab. Dispos. 2014 42 9 1532 1539 10.1124/dmd.114.059394 25002747
    [Google Scholar]
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Polyphenolics Profile of Casimiora edulis Llave. and Evaluation of its Hepatoprotective Potential
Bentham Science Publishers ; https://doi.org/10.2174/0115734072368019250220042134
/content/journals/cbc/10.2174/0115734072368019250220042134
/content/journals/cbc/10.2174/0115734072368019250220042134
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  • Article Type:     Research Article
Keywords: phenolic contents ; Casimiora edulis ; and hepatoprotective potential ; paracetamol ; oxidative stress biomarkers ; HPLC

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