Current Analytical Chemistry - Online First

Background L-cysteine (L-Cys) and homocysteine (Hcy) are the most representative of biothiol, which exist widely in organisms. L-Cys is one of the essential amino acids, which can be absorbed from protein-rich food and plays a considerable role in various physiological processes. Hcy is a vital intermediate in normal mammalian metabolism of methionine but does not occur in the diet. Therefore, it is significant to exploit a rapid Read More

Background Despite the widespread use of Ephedra altissima plant in traditional Algerian medicine, the biological potential of this species has still not been well explored. Objective This study, for the first time, focused on determining the effect of extraction methods and solvents on the phenolic content and antioxidant ability of the aerial part of Ephedra altissima. Methods Extraction was carried out by maceration and S Read More

Background Milk, an essential part of diet is comprised of all indispensable nutrients. However, it proves to be beneficial only if it is available in its pure form. Objective The current study aimed to evaluate packaged milk samples collected from local markets of Karachi and to assess level of consumer awareness about health risks associated with substandard milk consumption. Methods Package milk samples were assessed c Read More

Over the decade many types of fluorescent sensors have been developed for detecting diverse types of analyte. The sensors developed using the phenomenon of fluorescence provide high sensitivity, selectivity, for the analyte that they are being developed for. This has led to a huge increase in development of sensors for biomarkers that are particularly of importance for early detection or diagnosis of life threatening diseases Read More

Introduction In this study, aiming to solve the problem of difficult recovery of powder catalysts in the treatment of antibiotic wastewater by photocatalytic technology, titanium dioxide nanotubes (TiO2 NTs) photoelectrodes were prepared on titanium sheet substrates by anodic oxidation method. Methods The precious metals Pd and Ag were introduced to be co-deposited, which realized the effective transfer of photogene Read More

In recent years, microfluidics systems have emerged as powerful tools for biological analysis, integrating entire analytics protocols into a single chip platform. This article aims to review recent developments in microfluidics systems for diagnostics applications, focusing on genes, proteins, and cells. By categorizing fluids- manipulating mechanisms and biological detection approaches, the articles provide an in-depth discussion o Read More

Introduction In this study, the contents of essential and non-essential elements in the sugary and sugar-free varieties of aromatic coffees produced in Turkey were decided, and the effect of sugar addition was examined. Method For this purpose, essential (Mg, Se, B, Na, Ca, K, Co, Cr, Fe, Cu, Mn, Mo, P and Zn) and non-essential (As, Ba, Al, Cd, Ti, Ni, Sb and Pb) element contents of the aromatic coffees (sugary and sugar-free) (Cla Read More

Background Ubrogepant is a regulated peptide receptor antagonist associated with the calcitonin gene, granted approval in the United States for the specific treatment of migraine headaches. Objective An impurity found in the alkali hydrolysis of drug dosage forms has a structure very similar to that of ubrogepant. This research aims to characterize this analogous impurity utilizing NMR and LC-MS spectroscopy tools. Moreover, Read More

Background PYX-201 is an Antibody-Drug Conjugate (ADC) composed of a fully human IgG1 antibody, a cleavable linker mcValCitPABC, and toxic auristatin payloads Aur0101, with a drug antibody ratio (DAR) of approximately 4. PYX-201 is a promising candidate for oncology treatment because it targets the extra domain B splice variant of fibronectin (EDB + FN), which is expressed at low levels in normal adult tissues w Read More

AimsVenetoclax is a selective inhibitor of the prosurvival protein BCL-2 approved by the Food Drug Administration in 2016, restoring the apoptic ability of malignant cells. In this study, a fast, highly accurate and precise HPLC method was developed for the analysis of Venetoclax in human plasma.MethodsThe optimization of the method was investigated according to Box-Bhenken Design combined with 3D surface methodol Read More