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Current Analytical Chemistry - Online First
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Novel Chiral HPLC Method for Accurate Identification and Quantification of RS Enantiomers in Ropivacaine on Immobilized Chiral Stationary Phase: Development and Validation
Available online: 04 October 2024More LessPurpose Ropivacaine is a widely used local anesthetic for managing postoperative pain, particularly in procedures such as caesarean sections. While historically used as a racemate, its structural similarity to mepivacaine and bupivacaine within the pipecoloxylidide group is notable. Both enantiomers of ropivacaine exhibit similar nerve-blocking properties, but the R enantiomer is associated with increased cardiotoxicity co Read More
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Investigation of Voltametric Behavior and Antioxidant Activity of Vanillin-based Chalcone Compound
Available online: 02 October 2024More LessBackground Chalcone-type molecules are significant compounds due to their biocompatible properties. This study aimed to examine the electrochemical properties of vanillin chalcone monomer (VC) and its polymer (PANI-VC), as well as to investigate the antioxidant properties of the vanillin chalcone monomer. Methods VC and PANI-VC were synthesized and characterized using FTIR and UV-Vis spectroscopy. The elect Read More
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An Efficient and Cost-effective Modified Carbon Paste Electrodes for Diltiazem Hydrochloride Determination in Tablets
Available online: 02 September 2024More LessBackground and Objective This study presented new sensitive and selective modified carbon paste (MCPE) potentiometric sensors modified with different ion pairs for the determination of the antihypertensive drug diltiazem hydrochloride (DTM-HCl) in biological fluids, pharmaceutical preparations, and in its pure form. Methods Plasticizers, ion pair type, ion pair content, response time, temperature, and pH were just a Read More
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Progress in the Development of Antifouling Electrochemical Biosensors
Authors: Liuxing Chen, Da Chen and Meiling LianAvailable online: 02 September 2024More LessElectrochemical biosensors a subclass of biosensors, consisting of a biosensing element and an electrochemical transducer, have been widely used in various fields due to their excellent performance and portable device. However, in complex actual samples, non-specific adsorption of proteins and solid particles, and adhesion of cells and bacteria will lead to problems such as reduced sensor sensitivity, prolonged response time, Read More
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