Pharmacology
A Comprehensive Review of Promising Phytoconstituents as Anti-Cancer Agents: Biological Mechanisms and Applications Across Different Cancers
Jul 2025
Article
Source:
Current Nanoscience
21,
pp 613
- 639
(2025)
Cancer claiming approximately 10 million lives annually remains a leading cause of global mortality. Conventional cancer treatments notably chemotherapy and radiotherapy often entail adverse effects such as cytotoxicity and the development of resistance posing significant challenges in cancer management. While natural products have historically served medicinal purposes for various ailments their recent prominence in combating cancer-related man Read More
Recent Advances in Water-Soluble Polymer and Polymeric Nanoparticles for Pharmaceutical Application
Jul 2025
Article
Source:
Current Nanoscience
21,
pp 565
- 584
(2025)
Polymers are supermolecules or huge molecules that have a central role as an excipient in any dosage formulation. Currently the usage of polymers in drug formulation is often associated with numerous problems connected with drug release side effects and carcinogenic effects. Therefore the utilization of water-soluble polymers and polymeric nanoparticles has been favoured to minimize these types of problems. Polymers can be found in natural and synt Read More
Electrochemical Sensors Go Nano: Carbon Nanomaterials for Ultrasensitive Heavy Metal Analysis
Jul 2025
Article
Source:
Current Nanoscience
21,
pp 596
- 612
(2025)
BackgroundHeavy metal contamination of food and the environment is a major concern worldwide. Conventional detection techniques like atomic absorption spectroscopy (AAS) inductively coupled plasma-optical emission spectrometry (ICP-OES) and inductively coupled plasma-mass spectrometry (ICP-MS) have limitations including high costs and insufficient sensitivity. Electrochemical sensors based on carbon nanomaterials have emerged as an attractive Read More
Silicon Carbide-based Materials from Rice Husk
Jul 2025
Article
Source:
Current Nanoscience
21,
pp 585
- 595
(2025)
BackgroundRice husk is an important agricultural waste that contains organic mass and bio-silica. Although some rice husks have been used as fuel animal food filler for wine fermentation and fertilizer the majority are discarded as agricultural waste which does great harm to the environment. The conversion of rice husk to silicon carbide (SiC)-based materials satisfies the demand for the reutilization of solid wastes.MethodsThe article reviews recent progr Read More
Novel Approaches and Applications of Nanotechnology in the Delivery of Topical Drugs for Psoriasis via Nanocarriers
Jul 2025
Article
Source:
Current Nanoscience
21,
pp 658
- 684
(2025)
Psoriasis is a non-contagious continuing auto-immune disease that mostly affects the skin and about 2%-3% of the world's population suffers from it. In this review article the primary focus is on the strategies involved in conventional therapies and the latest advances that have been recorded in metallic nano polymer-based and lipid-based formulations in the spectrum of anti-psoriatic drugs. Liposomes ethosomes solid lipid nanoparticles micelles and de Read More
Cyclamen libanoticum is a Novel Bioresource for Green Silver Nanoparticles with Antibacterial and Antioxidant Capabilities
Jul 2025
Article
Source:
Current Nanoscience
21,
pp 731
- 748
(2025)
BackgroundIt has become essential to look into alternatives that effectively stop bacterial infections due to the exponential rise in antibiotic resistance. The field of nanotechnology has made significant strides in development by surmounting obstacles that have impeded success and advancement in other fields. Nanoparticles (NPs) are the key component in the burgeoning field of nanotechnology.ObjectiveCyclamen libanoticum leaf extract (CLE) was used Read More
Choline Based Surfactants Promote Cellular Uptake of Solid Lipid Nanoparticles into Lung and Breast Cancer Cells
Jul 2025
Article
Source:
Current Nanoscience
21,
pp 702
- 717
(2025)
AimsThe aim of this study was to synthesize two positively charged surfactants Stearoylcholine and Oleoylcholine from choline or vitamin B4 saturated and mono-unsaturated fatty acids to modify solid lipid nanoparticles (SLNs) in order to enhance cancer cell uptake.MethodsThese surfactants were synthesized by using the esterification method and then SLN formulations of unmodified and modified SLNs containing docetaxel were prepared by emulsification Read More
Weaving the Future of Topical Medicine: A Journey with Electrospinning Nanofibre Scaffolds
Jul 2025
Article
Source:
Current Nanoscience
21,
pp 640
- 657
(2025)
The pharmaceutical sciences are gradually shielding mankind from a plethora of deadly but as-of-yet-undiscovered ailments. Many diseases some of which can be fatal have their initial line of defence on the skin. A significant challenge for scientists is the development of appropriate pharmacological formulations for transdermal drug administration. Low side effect risk reduces first-pass impact and good patient compliance makes transdermal distribution su Read More
Improved Electrocatalytic Degradation of Alizarin Yellow R by Ti/Zr-SnO2/PbO2 Electrodes Doped with Ytterbium
Jul 2025
Article
Source:
Current Nanoscience
21,
pp 685
- 701
(2025)
IntroductionElectrochemical oxidation of Alizarin Yellow R (AYR) was investigated on Ytterbium (Yb) doped Ti/PbO2 electrodes prepared by an electrodeposition method.MethodsThe etching of the Ti sheet by using a mixed acid of H2SO4 and TA (volume ratio= 2: 1) for 50 min at 100°C could produce a suitable interface for further modification. The morphologies composition and electrochemical properties of Yb doping on the electrode were ch Read More
Quantitative Study on the Electrothermal Properties of Carbon Nanotube Film and its Out-of-Autoclave-Manufactured Glass Fiber-Reinforced Epoxy-Resin Composites
Jul 2025
Article
Source:
Current Nanoscience
21,
pp 718
- 730
(2025)
BackgroundCarbon nanotube films are utilized in various fields particularly electric heating owing to their exceptional thermal and electrical properties. However quantitative research on the electrothermal characteristics of carbon nanotube film is insufficient and glass fiber-reinforced epoxy-resin composites prepared through the electrothermal method of carbon nanotube films (i.e. the out-of-autoclave technique) have not yet been reported.Material a Read More
Therapeutic Effect of Unmodified Gold-platinum Nanoparticles on Gouty Arthritis Via the Nrf2/HO-1 Pathway
Jul 2025
Article
Source:
Current Nanoscience
21,
pp 757
- 765
(2025)
BackgroundGouty arthritis characterized by excruciating pain and discomfort poses a significant burden on patients. While nanomedicines have shown promise in addressing this ailment their complicated synthesis processes often involve potentially toxic procedures contributing to adverse side effects in disease management.MethodsIn this study we introduce a straightforward and elegant solution by utilizing easily prepared gold platinum (AuPt) na Read More
Two-Dimensional NiCo2S4 Nanosheets Deliver Efficient Oxygen Evolution Reaction
Jul 2025
Article
Source:
Current Nanoscience
21,
pp 749
- 756
(2025)
IntroductionThe development of cost-effective and efficient catalysts plays a pivotal role in the realization of hydrogen production through electrochemical water splitting.MethodsIn this study two-dimensional NiCo2S4 nanosheets were synthesized using a hydrothermal method followed by a sulfidation process.ResultsThe resulting materials were thoroughly characterized to understand their morphology and structure. The findings indicate that th Read More
Anticipating Viral Challenges: A Perspective on Phytochemicals against Existing and Emerging Viruses
Jun 2025
Article
Source:
Anti-Infective Agents
23,
E22113525312781
(2025)
Viral infections impact millions of individuals annually and in 2018 the WHO called for global preparedness to address potential high-mortality pathogens referred to as “Pathogen X” which can include fungi viruses parasites or prions. The constant evolution of RNA viruses leads to continually changing variants challenging the effectiveness of vaccines and drugs. In underserved healthcare regions plant-based phytochemicals offer promise in combating vi Read More
Successful Identification of Key Phytoconstituents of Emblica officinalis as Potential Multitargeting Anti-Inflammatory and Antifungal Agents
Jun 2025
Article
Source:
Anti-Infective Agents
23,
E22113525331096
(2025)
IntroductionFungal infections are growing more rapidly and becoming a public health concern worldwide. The use of herbal medicines is now increasing due to their many functional properties with fewer side effects. Emblica officinalis an important medicinal plant exhibits many therapeutic properties.MethodsIn this article the active phytoconstituents of Emblica officinalis were explored for their multitargeting activity as anti-inflammatory and antifungal by Read More
A Comprehensive Review on the Antimicrobial Activities and Structure-Activity Relationships (SARs) of Rhodanine Analogues
Jun 2025
Article
Source:
Anti-Infective Agents
23,
E22113525295259
(2025)
Rhodanines are five-member heterocyclics having sulfur nitrogen and oxygen atoms in their ring structure and exhibit potent as well as a broad range of pharmacological activities. They are thiazolidine derivatives and are well-known in medicinal chemistry for their wide spectrum of antimicrobial activities. Various modifications can be made to the structure of the rhodanine ring. Studies in recent years have validated the possibility of the potential of r Read More
Role of Essential oils in Wound Healing
Jun 2025
Article
Source:
Anti-Infective Agents
23,
E22113525299650
(2025)
As we know the skin is part of our body which acts as a protective barrier and protects us from deleterious agents. Any damage or destruction to the skin causes a rupture of the epidermis layer of skin. These wounds may lead to many problems if untreated such as infection and inflammation which result in slowing the natural wound healing process. In recent years there have been numerous approaches and therapies available in the market. These a Read More
Biological Mechanisms of Polyphenols against Clostridium Difficile: A Systematic Review
May 2025
Article
Source:
Infectious Disorders - Drug Targets (Formerly Current Drug Targets - Infectious Disorders)
25,
E18715265313944
(2025)
BackgroundClostridium difficile is an opportunistic infection that can lead to antibiotic-associated diarrhea and toxic megacolon.ObjectiveThis systematic review study aimed to investigate polyphenols' antibacterial and anti-toxin properties and their effects on reducing complications related to C. difficile Infections (CDI).MethodsThis systematic review was conducted following the PRISMA guideline 2020. Multiple databases including Web of Science Read More
A Review over Mitochondrial Diseases Due to mtDNA Mutations: Recent Advances and Remedial Aspects
May 2025
Article
Source:
Infectious Disorders - Drug Targets (Formerly Current Drug Targets - Infectious Disorders)
25,
E18715265304029
(2025)
Mitochondria also called ‘powerhouse of the cell’ is meant for energy generation in eukaryotic cells. This action is performed by mitochondria through the oxidative phosphorylation (OXPHOS) of the respiratory chain (RC). Based on the functioning of the cell the number of mitochondria varies up to thousands in number. Mutations in the mitochondrial DNA (mtDNA) and/or nuclear DNA (nDNA) genes may lead to the generation of primary mitochondrial dise Read More
Structural Prediction and Antigenic Analysis of ROP18, MIC4, and SAG1 Proteins to Improve Vaccine Design against Toxoplasma gondii: An In silico Approach
May 2025
Article
Source:
Infectious Disorders - Drug Targets (Formerly Current Drug Targets - Infectious Disorders)
25,
E18715265332103
(2025)
BackgroundToxoplasmosis is a cosmopolitan infectious disease in warm-blooded mammals that poses a serious worldwide threat due to the lack of effective medications and vaccines.AimsThe purpose of this study was to design a multi-epitope vaccine using several bioinformatics approaches against the antigens of Toxoplasma gondii (T. gondii).MethodsThree proteins of T. gondii including ROP18 MIC4 and SAG1 were analyzed to predict the most dominant B Read More
A Review of the Difficulties Faced by Low and Middle-income Countries in Hygiene and Healthcare Practices
May 2025
Article
Source:
Infectious Disorders - Drug Targets (Formerly Current Drug Targets - Infectious Disorders)
25,
E18715265307717
(2025)
Hygiene has been identified as an important step in anticipating health-related pollution with conflicting reports about consistent sanitation standards in the nation. This narrative review of published studies has led to the discussion of hand hygiene and health practices as well as the identification of necessary methods that are available in low and middle-income countries. An effective survey of accessible information is conducted in this way based on re Read More
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