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2000
Volume 23, Issue 3
  • ISSN: 2211-3525
  • E-ISSN: 2211-3533

Abstract

As we know, the skin is part of our body, which acts as a protective barrier and protects us from deleterious agents. Any damage or destruction to the skin causes a rupture of the epidermis layer of skin. These wounds may lead to many problems if untreated, such as infection and inflammation, which result in slowing the natural wound healing process. In recent years, there have been numerous approaches and therapies available in the market. These approaches are painful and cause uneasiness to patients. The majority of wound treatment formulations contain antibiotics or synthetic moieties, which can lead to serious issues, such as drug resistance or allergy. contains several secondary metabolites of aromatic medicinal plants known as , which have shown potential benefits in wound healing. They help to prevent further infection due to their antibacterial and anti-inflammatory properties. The present article highlights the various studied in wound healing management and their patents.

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2024-09-05
2025-07-23

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References

  1. GushikenL.F.S. BeserraF.P. BastosJ.K. JacksonC.J. Pellizzon, C.H. Cutaneous wound healing: An update from physiopathology to current therapies.Life202111766510.3390/life11070665 34357037
     [Google Scholar]
  2. GuanC.P. ZhouM.N. XuA.E. KangK.F. LiuJ.F. WeiX.D. The skin: An indispensable barrier.Exp. Dermatol.200817121059106210.1111/j.1600‑0625.2008.00752.x 18537816
     [Google Scholar]
  3. Peng-HuiW. Ben ShianH. Huann-ChengH. Change-ChingY. Yi-JenC. Wound healing.J. Chin. Med. Assoc.20188129410110.1016/j.jcma.2017.11.002
     [Google Scholar]
  4. SingerA.J. ClarkR.A.F. Cutaneous wound healing.N. Engl. J. Med.19993411073874610.1056/NEJM199909023411006 10471461
     [Google Scholar]
  5. ShankarM. RameshB. Roopa KumarD. Niranjan BabuM. Wound healing & its importance: A review.Der Pharmacologia Sinica2014112430
     [Google Scholar]
  6. EnochS PriceP Cellular molecular and biochemical differences in the patho physiology of healing between acute wounds, chronic wounds and wounds in the aged.Worldwide wounds2004
     [Google Scholar]
  7. MoreoK. Understanding and overcoming the challenges of effective case management for patients with chronic wounds.Case Manager2005162626710.1016/j.casemgr.2005.01.014 15818347
     [Google Scholar]
  8. MustoeT. Understanding chronic wounds: A unifying hypothesis on their pathogenesis and implications for therapy.Am. J. Surg.20041875S65S7010.1016/S0002‑9610(03)00306‑4 15147994
     [Google Scholar]
  9. DatA.D. PoonF. PhamK.B. DoustJ. Aloe vera for treating acute and chronic wounds. Sao paulo medical journal =.Rev. Paul. Med.20141326382
     [Google Scholar]
  10. RamasastryS.S. Acute wounds.Clin. Plast. Surg.200532219520810.1016/j.cps.2004.12.001 15814117
     [Google Scholar]
  11. DubayD.A. FranzM.G. Acute wound healing: The biology of acute wound failure.Surg. Clin. North Am.200383346348110.1016/S0039‑6109(02)00196‑2 12822720
     [Google Scholar]
  12. OkurM.E. KarantasI.D. ŞenyiğitZ. Üstündağ OkurN. SiafakaP.I. Recent trends on wound management: New therapeutic choices based on polymeric carriers.Asian Journal of Pharmaceutical Sciences202015666168410.1016/j.ajps.2019.11.008 33363624
     [Google Scholar]
  13. RodriguesM. KosaricN. BonhamC.A. GurtnerG.C. Wound healing: A cellular perspective.Physiol. Rev.201999166570610.1152/physrev.00067.2017 30475656
     [Google Scholar]
  14. LaroucheJ. SheoranS. MaruyamaK. MartinoM.M. Immune regulation of skin wound healing: Mechanisms and novel therapeutic targets.Adv. Wound Care20187720923110.1089/wound.2017.0761 29984112
     [Google Scholar]
  15. ReinkeJ.M. SorgH. Wound repair and regeneration.Eur. Surg. Res.2012491354310.1159/000339613 22797712
     [Google Scholar]
  16. TottoliE.M. DoratiR. GentaI. ChiesaE. PisaniS. ContiB. Skin wound healing process and new emerging technologies for skin wound care and regeneration.Pharmaceutics202012873510.3390/pharmaceutics12080735 32764269
     [Google Scholar]
  17. VeithA.P. HendersonK. SpencerA. SligarA.D. BakerA.B. Therapeutic strategies for enhancing angiogenesis in wound healing.Adv. Drug Deliv. Rev.20191469712510.1016/j.addr.2018.09.010 30267742
     [Google Scholar]
  18. Tomic-CanicM. WongL.L. SmolaH. The epithelialisation phase in wound healing: options to enhance wound closure.J. Wound Care2018271064665810.12968/jowc.2018.27.10.646 30332358
     [Google Scholar]
  19. KarppinenS.M. HeljasvaaraR. GullbergD. TasanenK. PihlajaniemiT. Toward understanding scar less skin wound healing and pathological scarring.F1000 Res.2019878710.12688/f1000research.18293.1 31231509
     [Google Scholar]
  20. MartinsV.L. CaleyM. O’TooleE.A. Matrix metalloproteinases and epidermal wound repair.Cell Tissue Res.2013351225526810.1007/s00441‑012‑1410‑z 22526628
     [Google Scholar]
  21. FerrarioC. RusconiF. PulajA. MacchiR. LandiniP. ParoniM. ColomboG. MartinelloT. MelottiL. GomieroC. Candia CarnevaliM.D. BonasoroF. PatrunoM. SugniM. From food waste to innovative biomaterial: Sea urchin-derived collagen for applications in skin regenerative medicine.Mar. Drugs202018841410.3390/md18080414 32781644
     [Google Scholar]
  22. VarkeyM. DingJ. TredgetE. Advances in skin substitutes-potential of tissue engineered skin for facilitating anti-fibrotic healing.J. Funct. Biomater.20156354756310.3390/jfb6030547 26184327
     [Google Scholar]
  23. PowersJ.G. HighamC. BroussardK. PhillipsT.J. Wound healing and treating wounds.J. Am. Acad. Dermatol.201674460762510.1016/j.jaad.2015.08.070 26979353
     [Google Scholar]
  24. SoutoE.B. BaldimI. OliveiraW.P. RaoR. YadavN. GamaF.M. MahantS. SLN and NLC for topical, dermal, and transdermal drug delivery.Expert Opin. Drug Deliv.202017335737710.1080/17425247.2020.1727883 32064958
     [Google Scholar]
  25. BoatengJ.S. MatthewsK.H. StevensH.N.E. EcclestonG.M. Wound healing dressings and drug delivery systems: A review.J. Pharm. Sci.20089782892292310.1002/jps.21210 17963217
     [Google Scholar]
  26. WangT. JianZ. BaskysA. YangJ. LiJ. GuoH. HeiY. XianP. HeZ. LiZ. LiN. LongQ. MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system.Biomaterials202025712026410.1016/j.biomaterials.2020.120264 32791387
     [Google Scholar]
  27. RafiqM. HussainT. AbidS. NazirA. MasoodR. Development of sodium alginate/PVA antibacterial nanofibers by the incorporation of essential oils.Mater. Res. Express20185303500710.1088/2053‑1591/aab0b4
     [Google Scholar]
  28. MoriH.M. KawanamiH. KawahataH. AokiM. Wound healing potential of lavender oil by acceleration of granulation and wound contraction through induction of TGF-β in a rat model.BMC Complement. Altern. Med.201616114410.1186/s12906‑016‑1128‑7 27229681
     [Google Scholar]
  29. AndjićM. BožinB. DraginićN. KočovićA. JeremićJ.N. TomovićM. Milojević ŠamanovićA. KladarN. ČapoI. Jakovljević, V.; Bradić, J.V. Formulation and evaluation of helichrysum italicum essential oil-based topical formulations for wound healing in diabetic rats.Pharmaceuticals202114881310.3390/ph14080813 34451910
     [Google Scholar]
  30. EbrahimiA. Reza FarahpourM. AmjadiS. MohammadiM. HamishehkarH. Nanoliposomal peptides derived from Spirulina platensis protein accelerate full-thickness wound healing.Int. J. Pharm.202363012245710.1016/j.ijpharm.2022.122457 36455754
     [Google Scholar]
  31. ChuS.S. Feng Hu J.; Liu, Z.L. Composition of Essential oil of Chinese Chenopodium ambrosioides and insecticidal activity against maize weevil, Sitophilus zeamais.Pest Manag. Sci.201167671471810.1002/ps.2112 21360645
     [Google Scholar]
  32. Al-DhahliA.S. Al-HassaniF.A. Mohammed AlarjaniK. Mohamed Yehia, H.; Al Lawati, W.M.; Najmul Hejaz Azmi, S.; Alam Khan, S. Essential oil from the rhizomes of the Saudi and Chinese Zingiber officinale cultivars: Comparison of chemical composition, antibacterial and molecular docking studies.J. King Saud Univ. Sci.20203283343335010.1016/j.jksus.2020.09.020
     [Google Scholar]
  33. GuoS.S. WangY. ChenZ.Y. ZhangZ. CaoJ.Q. PangX. GengZ-F. DuS-S. Essential oils from clausena species in china: santalene sesquiterpenes resource and toxicity against liposcelis bostrychophila.J. Chem.201820181810.1155/2018/7813675
     [Google Scholar]
  34. Tea tree Essential oil chinese.Available from: https://www.kusharomaexports.com/essential-oils/tea-tree-essential-oil-chinese
  35. ChuS.S. DuS.S. LiuZ.L. Fumigant compounds from the essential oil of chinese blumea balsamifera leaves against the maize weevil (sitophilus zeamais).J. Chem.201320131710.1155/2013/289874
     [Google Scholar]
  36. Seyed AhmadiS.G. FarahpourM.R. HamishehkarH. Topical application of Cinnamon verum Essential oil accelerates infected wound healing process by increasing tissue antioxidant capacity and keratin biosynthesis.Kaohsiung J. Med. Sci.2019351168669410.1002/kjm2.12120 31448873
     [Google Scholar]
  37. Method and apparatus for authenticating a magnetic fingerprint signal using an adaptive analog to digital converter. U.S. Patent 7,210,6272007
  38. RolfD. Inhalation Antiviral Patch.US-20040071757-A1.Axogen Inc.Portal.unifiedpatents.com/patent2004
  39. Muhammed M. and Subbalakshmi P.; Composition and Methods containg an antimicrobial Essential oil extracted from Coleus forskohlii, US-6607712-B22003
     [Google Scholar]
  40. FoglioM.J. Pharmaceutical compositions comprising arrabidaea chica extract in controlled release systems, production process and use thereof. W.O.Patent 2013091056A12013
  41. KhanA. Novel approaches for herbal drug delivery in wound healing.Indian J. Pharm. Sci.2022842247260
     [Google Scholar]
  42. WALIA P.A. A multifunctional natural wound healing matrix.Google Patents2014
     [Google Scholar]
  43. Al-MutawaaM.G.M. Ointment for healing burns and wounds.Google Patents2014
     [Google Scholar]
  44. MirzaeiE. Electro spun nanofibrous wound dressing and a method of synthesizing the same.Google Patents2015
     [Google Scholar]
  45. WellerK-A.C. WellerK.F. McLoughlinN.J. A topical herbal healing formulation.Google Patents2020
     [Google Scholar]
  46. ShraibomN. Herbal combinations for wound healing in fibroblasts.Google Patents2018
     [Google Scholar]
  47. TomulewiczM. Herbal preparation for accelerating wounds and skin inflammations healing and its application.Google Patents2019
     [Google Scholar]
  48. TomulewiczM. Herbal preparation for accelerating wounds and skin inflammations healing, especially for treatment of herpes and acne, and its application.Google Patents2021
     [Google Scholar]
  49. AhnS. Biomimetic pro-regenerative scaffolds and methods of use thereof.Google Patents2020
     [Google Scholar]
  50. PandeyP. GulatiN. MakhijaM. PurohitD. DurejaH. Nanoemulsion: A novel drug delivery approach for enhancement of bioavailability.Recent Pat. Nanotechnol.202014427629310.2174/1872210514666200604145755 32496999
     [Google Scholar]
  51. Salas-OropezaJ. Jimenez-EstradaM. Perez-TorresA. CastellRodriguez, A.E.; Becerril-Millan, R.; Rodriguez-Monroy, M.A.; Canales-Martinez, M.M. Wound healing activity of the Essential oil of Bursera morelensis, in mice.Molecules2020258179510.3390/molecules25081795 32295241
     [Google Scholar]
  52. Vila NovaB.G. SilvaL.S. AndradeM.S. de SantanaA.V.S. daSilvaL.C.T. SáG.C. ZafredI.F. MoreiraP.H.A. MonteiroC.A. da SilvaL.C.N. AbreuA.G. The Essential oil of melaleuca alternifolia incorporated into hydrogel induces antimicrobial and anti-inflammatory effects on infected wounds by staphylococcus aureus.Biomed. Pharmacother.202417311638910.1016/j.biopha.2024.116389 38461682
     [Google Scholar]
  53. BahloulB. Ben BninaE. HamdiA. Castillo HenríquezL. Baccar, D.; Kalboussi, N.; Abbassi, A.; Mignet, N.; Flamini, G.; VegaBaudrit, J.R. Investigating the wound-healing potential of a nanoemulsion–gel formulation of pituranthos tortuosus essential oil.Gels202410315510.3390/gels10030155 38534573
     [Google Scholar]
  54. CaiK. LiuY. YueY. LiuY. GuoF. Essential oil nanoemulsion hydrogel with anti-biofilm activity for the treatment of infected wounds.Polymers2023156137610.3390/polym15061376 36987156
     [Google Scholar]
  55. NikolicM. AndjicM. BradicJ. KocovicA. TomovicM. SamanovicA.M. JakovljevicV. VeselinovicM. CapoI. Krstonosic, V.; Kladar, N.; Petrovic, A. Topical application of siberian pine Essential oil formulations enhance diabetic wound healing.Pharmaceutics20231510243710.3390/pharmaceutics15102437 37896197
     [Google Scholar]
  56. KhezriK. FarahpourM.R. Mounesi RadS. Accelerated infected wound healing by topical application of encapsulated Rosemary essential oil into nanostructured lipid carriers.Artif. Cells Nanomed. Biotechnol.201947198098810.1080/21691401.2019.1582539 30857435
     [Google Scholar]
  57. LiubaviciuteA. IvaskieneT. BiziulevicieneG. Modulated mesenchymal stromal cells improve skin wound healing.Biologicals20206711810.1016/j.biologicals.2020.08.003 32828641
     [Google Scholar]
  58. ZhangA. LiuY. QinD. SunM. WangT. ChenX. Research status of self-healing hydrogel for wound management: A review.Int. J. Biol. Macromol.20201642108212310.1016/j.ijbiomac.2020.08.109 32798548
     [Google Scholar]
  59. XiangJ. ShenL. HongY. Status and future scope of hydrogels in wound healing: Synthesis, materials and evaluation.Eur. Polym. J.202013010960910.1016/j.eurpolymj.2020.109609
     [Google Scholar]
  60. MoeiniA. PedramP. MakvandiP. MalinconicoM. Gomez d’AyalaG. Wound healing and antimicrobial effect of active secondary metabolites in chitosan-based wound dressings: A review.Carbohydr. Polym.202023311583910.1016/j.carbpol.2020.115839 32059889
     [Google Scholar]
  61. MauryaA. SinghV.K. DasS. PrasadJ. KediaA. UpadhyayN. DubeyN.K. DwivedyA.K. Essential oil nanoemulsion as eco-friendly and safe preservative: Bioefficacy against microbial food deterioration and toxin secretion, mode of action and future opportunities.Front. Microbiol.20211275106210.3389/fmicb.2021.751062 34912311
     [Google Scholar]
  62. SulimanR.S. AlghamdiS.S. AliR. AljatliD. AljammazN.A. HuwaiziS. SulimanR. KahtaniK.M. AlbadraniG.M. BarhoumiT. AltolayyanA. RahmanI. The role of myrrh metabolites in cancer, inflammation, and wound healing: Prospects for a multi-targeted drug therapy.Pharmaceuticals202215894410.3390/ph15080944 36015092
     [Google Scholar]
  63. AhujaA. GuptaJ. GuptaR. Miracles of herbal phytomedicines in treatment of skin disorders: natural healthcare perspective.Infect. Disord. Drug Targets202121332833810.2174/1871526520666200622142710 32568024
     [Google Scholar]
  64. GargA. ChaturvediS. A comprehensive review on chrysin: Emphasis on molecular targets, pharmacological actions and biopharmaceutical aspects.Curr. Drug Targets202223442043610.2174/1389450122666210824141044 34431464
     [Google Scholar]
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Role of Essential oils in Wound Healing
Anti Infect. Agents 23, E22113525299650 (2025); https://doi.org/10.2174/0122113525299650240802064050
/content/journals/aia/10.2174/0122113525299650240802064050
/content/journals/aia/10.2174/0122113525299650240802064050
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  • Article Type:     Review Article
Keyword(s): deleterious agents; essential oil; monoterpenes; terpenoids; volatile oil; Wound healing

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