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Volume 23, Issue 3
  • ISSN: 2211-3525
  • E-ISSN: 2211-3533

Abstract

Rhodanines are five-member heterocyclics having sulfur, nitrogen, and oxygen atoms in their ring structure and exhibit potent as well as a broad range of pharmacological activities. They are thiazolidine derivatives and are well-known in medicinal chemistry for their wide spectrum of antimicrobial activities. Various modifications can be made to the structure of the rhodanine ring. Studies in recent years have validated the possibility of the potential of rhodanine derivatives to exhibit antimicrobial activity against both Gram-positive and Gram-negative bacterial strains, as well as mycobacterial and fungal strains. In this review, the synthesis, biological activity, and Structure-activity Relationships (SARs) of molecules based on rhodanine against different microbes have been described.

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2025-04-22

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/content/journals/aia/10.2174/0122113525295259240815073809
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A Comprehensive Review on the Antimicrobial Activities and Structure-Activity Relationships (SARs) of Rhodanine Analogues
Anti Infect. Agents 23, E22113525295259 (2025); https://doi.org/10.2174/0122113525295259240815073809
/content/journals/aia/10.2174/0122113525295259240815073809
/content/journals/aia/10.2174/0122113525295259240815073809
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  • Article Type:     Review Article
Keyword(s): antibacterial; antifungal; antimicrobial; antimycobacterial; Rhodanine; thiazolidinone

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