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Volume 21, Issue 4
  • ISSN: 1573-4137
  • E-ISSN: 1875-6786

Abstract

Background

Gouty arthritis, characterized by excruciating pain and discomfort, poses a significant burden on patients. While nanomedicines have shown promise in addressing this ailment, their complicated synthesis processes often involve potentially toxic procedures, contributing to adverse side effects in disease management.

Methods

In this study, we introduce a straightforward and elegant solution by utilizing easily prepared gold platinum (AuPt) nanoparticles for the treatment of gouty arthritis. The synthesis of these nanoparticles involves the use of gold and platinum precursors in conjunction with NaBH4, simplifying the manufacturing process. Experimental models of gout were established in both and settings through lipopolysaccharide and monosodium urate crystal induction.

Results

Our findings revealed that AuPt nanoparticles exhibited potent anti-inflammatory effects against gout. This effect was attributed to their ability to activate the Nrf2/HO-1 pathway, resulting in pain alleviation and the inhibition of inflammation, ultimately leading to the reduction of joint edema. With their uncomplicated synthesis and promising therapeutic potential, these simply prepared AuPt nanoparticles emerge as a compelling candidate for pharmaceutical intervention in the treatment of gouty arthritis.

Conclusion

This approach not only holds the promise of delivering effective relief to patients but also minimizes the risk of unwanted side effects associated with complex nanomedicine synthesis processes.

© 2025 Bentham Science Publishers
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2024-07-15
2025-04-24

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Therapeutic Effect of Unmodified Gold-platinum Nanoparticles on Gouty Arthritis Via the Nrf2/HO-1 Pathway
Curr. Nanosci. 21, 757 (2025); https://doi.org/10.2174/0115734137294469240702070418
/content/journals/cnano/10.2174/0115734137294469240702070418
/content/journals/cnano/10.2174/0115734137294469240702070418
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  • Article Type:     Research Article
Keyword(s): anti-inflammatory effects; Gouty arthritis; nanomedicine synthesis processes; Nrf2/HO-1 pathway; side effects; Unmodified gold-platinum nanoparticles

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