Multidrug-resistant tuberculosis (MDR-TB) poses a persistent challenge to global health necessitating continuous efforts to enhance treatment efficacy. Bedaquiline a cornerstone in MDR-TB management presents biopharmaceutical challenges that impact its therapeutic potential. This review provides a comprehensive analysis of recent innovations in drug delivery strategies designed to optimize Bedaquiline's efficacy and improve MDR-TB treatme Read More

Medicinal plants are an integral part of the medical system in many countries around the world. Natural products have been used as important biological sources for drug discovery over the past half-century. Alkaloids are a group of natural compounds that contain a basic nitrogen atom. Oxoglaucine is a phytochemical of the oxoaporphines class phytochemical isolated from Aquilegia ecalcarata Maxim Corydalis yanhusuo Chasmanthera dependens Read More

BackgroundThe structural maintenance of chromosomes (SMC) proteins plays a noteworthy role in chromosome dynamics. Several recent studies reported that the condensin core subunits of structural maintenance of chromosomes 2 (SMC2) play important roles in the atypical mitosis of the Plasmodium life cycle and may perform different functions during different proliferative stages. For eukaryotes the structural maintenance of chromosomes (SMC) Read More

BackgroundAs the number of new cancer cases increases every year there is a necessity to develop new drugs for the treatment of different types of cancers. Plants' resources are considered to be huge reservoirs for therapeutic agents in nature. Among all the medicinal plants Oroxylum indicum is one of the most widely used medicinal plants in India China and Southeast Asian countries. Combinatorial drug treatment on the other hand is favored ov Read More

This review investigates the outcome of heavy metal contamination on the anti-cancer properties of medicinal plants. Heavy metal pollution is a significant environmental concern globally often found in soil and water due to industrial activities. Therapeutic plants are recognized because of their therapeutic attributes and their ability to absorbing these contaminants. This study examines how heavy metal exposure modifies the chemical composition a Read More

BackgroundTyrosine kinases have emerged as key stimulatory drivers in several cancer-related pathways. This is particularly evident in non-small cell lung cancer with regulating cell growth and apoptosis and so on. Tyrosine kinase inhibitors (TKI) are one breakthrough option that could improve the life quality of cancer patients.ObjectiveThis study aims to find more effective tyrosine kinase inhibitors.MethodsIn this study natural products from TargetMol tha Read More

Glioblastoma (GB) remains a formidable challenge in oncology with current treatment approaches providing only marginal improvements in patient outcomes. Despite significant advances in understanding its molecular and genetic characteristics median survival for untreated patients remains distressingly low emphasizing the urgent need for novel therapeutic strategies. This review comprehensively examines the standard first-line treat Read More

Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent neurodevelopmental disorder characterized by symptoms of hyperactivity inattention and impulsivity significantly impacting individuals' daily functioning and quality of life. This manuscript explores the intricate relationship between the gut microbiome and ADHD emphasizing the role of the gut-brain axis a bidirectional communication pathway linking the central nervous system (CNS) Read More

IntroductionGratiola officinalis L. (hedge hyssop) a medicinal plant of the Scrophulariaceae family has diuretic purgative and vermifuge properties. It is used as a herbal tea to treat chronic gastroenteritis renal colic jaundice and intestinal worms. Previously we have found that an extract from G. officinalis is nontoxic and has antitumor antioxidant antimicrobial antiinflammatory anticachexic and other properties. Our aims in this study were to separate Read More

Background and ObjectiveBenzothiazole derivatives a class of heterocyclic compounds exhibited diverse biological activities influenced by substituents in the thiazole ring. This study aimed to synthesize these compounds with two functional groups to investigate their potential as anticancer agents particularly against breast cancer. While previous research demonstrated the efficacy of 2-substituted benzothiazoles against glioma and cervical and pancre Read More