Current Organic Chemistry - Volume 25, Issue 20, 2021

Recent advances in the metal-catalyzed hydrofunctionalization of alkynes with carboxylic acids are comprehensively reviewed. Both inter- and intramolecular processes, leading respectively to enol esters and lactones, are discussed, as well as the involvement of these transformations in the synthesis of natural products and biologically active molecules, and the assembly of elaborated heterocyclic compounds through cas Read More

This account provides a broad overview of the application of solid metal catalysts in synthetic chemistry with a focus on the synthesis of medicinally important scaffolds or building blocks. Heterogeneous catalysis is a fundamental contributor to green or sustainable synthesis. Despite this, many synthetic chemists overwhelmingly focus on homogeneous methods, and due to their unfamiliarity with solid catalysts, many would not Read More

Heterocycles are very important scaffolds since many of them exhibit building blocks properties and good biological activities. Various chemical methods have been utilized for their synthesis and out of them, the environmentally benign approaches are highly demanding in view of the importance of green chemistry. There are vast pieces of literature available on sustainable and multi-component synthetic approaches, Read More

A microwave-assisted organic synthesis is an alternative approach towards the traditional way of heating to obtain desired bioactive scaffolds as a product. This method has transformed the approaches of organic synthesis, due to shorter reaction time with high product yields, modifications of selectivity, increased product purities, and simplification of workup procedures. The microwave-assisted reactions can be performed un Read More

Tubulin Polymerization Inhibitors (TPIs) are promising ligands utilized in chemotherapy for modern cancer treatment. However, the current TPIs exhibit many serious side effects that may pose limitations in chemotherapy. Combretastatin A-4 (CA-4) is a natural TPI that binds at the colchicine binding site located on microtubules. The only cis isomer of CA-4 is bio-active; however, due to its short half-life, it isomerizes quickly to i Read More

Bridged Nucleic Acids (BNA) or Locked Nucleic Acids (LNA) belong to a class of nucleic acid modification that is obtained by connecting the 2'-O and 4'-C of ribose sugar using a methylene bridge. This ‘bridging or locking’ of ribose sugar has a tremendous impact on the biological and biophysical properties of therapeutic nucleic acids. They have enhanced stability against nucleases and also have a higher binding affinity for the tar Read More

In carbohydrate chemistry, the synthesis of complex saccharides with well-defined structures is the most formidable process as it is quite strenuous to isolate carbohydrates in acceptable purity and amounts from natural sources. Therefore, complex saccharides with well-defined structures are often most conveniently accessed through chemical syntheses. This review mainly focuses on the methodologies for one-pot glycosylati Read More

Carbohydrates are fascinating molecular scaffolds known for their diverse applications in chemistry, biology, medicine, technology, and materials science. In addition, owing to the notable features of Room-Temperature Ionic Liquids (RTILs) such as high-yield, short reaction time, simple handling, excellent recyclability, and environmentally benign nature, they have been extensively utilized as green solvents, catalysts, or Read More