Current Organic Chemistry - Volume 25, Issue 13, 2021

Tandem and domino reactions constitute economic methodologies to prepare complex molecules starting from simple materials. Especially, combining these powerful procedures to asymmetric catalysis allows direct access to many elaborated chiral products, including important key intermediates in total syntheses of important biologically active compounds. A range of various types of chiral organocatalysts have alre Read More

Microwave (MW)-assistance may be a powerful tool in the Hirao P–C coupling reactions of vinyl/aryl halides with dialkyl phosphites in the presence of Pd-catalysts/Pligands elaborated forty years ago. This review surveys the development of this reaction by showing the expansion of the reagents and catalysts, as well as the information accumulated. The stress was laid on the “green” aspects, the simplification of the catalyst syste Read More

Polysaccharide-based materials have been widely used as the first-choice candidates for various applications, especially in the field of biomaterials. The primary reasons for this are the sustainable nature of these materials and their high bioavailability. Their ability to be easily chemically modified enables them to be utilized in various avenues, with oxidation of the backbone being one of the most common chemical modifications. A Read More

Asymmetric organic synthesis is of paramount importance in the development of drugs. Asymmetric addition reactions such as aldol reaction, Michael addition, and Mannich addition reactions are important carbon-carbon bond-forming reactions and have been employed in the synthesis of a broad range of biologically important molecules. Many of these reactions have been developed under solvent-free conditions or in gre Read More

The use of natural and environment-friendly energy sources for the betterment of the living society has become an active concern in both government and public sectors. Due to this, responsible use of global resources has become a growing concern among people. Similarly, in the chemical industry especially in pharmaceutical fields, there is constant pressure in reducing hazardous organic solvents and environmen Read More

Abstract: Ultrasonication, nowadays, is well-regarded as an effective green tool in implementing a plethora of organic transformations. The last decade has seen quite useful applications of ultrasound irradiation in synthetic organic chemistry. Ultrasound has already come out as a unique technique in green chemistry practice for its inherent properties of minimizing wastes and reducing energy and time, thereby increasing Read More

Recent years have witnessed a rapid development of environmentally sustainable organic processes that can stop the eventual depletion of our eco-system with wider implications on the day-to-day practice in academic laboratories and industries. The use of biocompatible raw materials as a catalyst, solvent, and synthetic precursors; continuous attempt to design ideal synthetic processes, and use of energy-efficient strategy, Read More

Most of the biologically active microbial natural products and their analogs bear a complex molecular architecture. The semisynthetic modifications and stereospecific diversity- oriented synthesis of these native natural products to generate analogs are difficult and time-consuming. Mutasynthesis is a powerful tool that utilizes the microorganism's genetic and metabolic engineering skills to produce derivatives of com Read More