Current Organic Chemistry - Volume 25, Issue 5, 2021

The synthesis of ester-containing heterocyclic compounds via multicomponent reaction is one of the preferable processes in synthetic organic chemistry and medicinal chemistry. Compounds containing ester linkage have a wide range of biological applications in the pharmaceutical field. Therefore, many methods have been developed for the synthesis of these types of derivatives. However, some of them are carried out i Read More

The deep eutectic mixtures (DESs), introduced as a novel alternative to usual volatile organic solvents for organic transformations, have attracted tremendous attention of the research community because of their low cost, negligible vapour pressure, low toxicity, biodegradability, recyclability, insensitivity towards moisture, and ready availability from bulk renewable resources. Although the low melting mixture of dimethyl urea Read More

N-Methyl-D-aspartate (NMDA) receptors, together with AMPA and kainite receptors, belong to the family of ionotropic glutamate receptors. NMDA receptors play a crucial role in neuronal plasticity and cognitive functions. Overactivation of those receptors leads to glutamate-induced excitotoxicity, which could be suppressed by NMDA antagonists. Dizocilpine was firstly reported in 1982 as an NMDA receptor antagonist Read More

This review summarizes the transition metal-catalyzed direct C–H functionalization of quinazolinones and quinazolines through C-C, C-N and C-O bond formations. It focuses mainly on the C-H (sp2 or sp3) bond arylation, amination, sulfamidation, acetoxylation, halogenation, annulation of quinazolinones and quinazolines. This review illustrates the scope of C-H activation and functionalization of various quinazolinone and qui Read More

Prins cyclization is a well-established synthetic protocol to generate a wide range of important oxygen heterocycles. It is a cyclization reaction performed by an oxocarbenium ion that undergoes an intramolecular pi-bond attack to construct a new carbon-carbon bond. When this cyclization process is conjugated with Friedel-Crafts reaction, it further expands the synthetic potential by fabricating two different carbon-carbon b Read More