Current Organic Chemistry - Volume 25, Issue 4, 2021

Indoxamycins A-F, a novel class of polyketides, were isolated from the saline culture of marine-derived actinomyces by Sato et al. in 2009. Intriguing stereochemical complexity involving tricyclic [5.5.6] cage-like structures with six consecutive chiral centers challenged many organic chemists. Chemical ingenuity, implementation of pioneered reactions along with fine chemical transformations allowed not only the rapi Read More

Seven membered heterocyclic Azepine and its derivatives have great pharmacological and therapeutic implications. In this review, the literature of the last fifty years has been exploited for the synthesis, reaction, and biological properties of these seven-member heterocyclic compounds. Most of the mechanisms involved the ring expansion of either five or six-membered compounds using various methods such as thermally, ph Read More

The ocean supplies abundant active compounds, including small organic molecules, proteins, lipids, and carbohydrates, with diverse biological functions. The high-value transformation of marine carbohydrates primarily refers to their pharmaceutical, food, and cosmetic applications. However, it is still a big challenge to obtain these marine carbohydrates in well-defined structures. Synthesis is a powerful approach to a Read More

C-1 substituted tetrahydroisoquinolines have emerged as important scaffolds in pharmaceutical and medical research. Although various methods for α-substitution on tetrahydroisoquinolines have been discovered, the introduction of the azole group at C-1 position remains a challenge. Recently, direct C-H activation methods and multicomponent reactions have been employed towards the synthesis of azole containing t Read More

The regioselectivity of the reaction of 2,5-dihydroxy-[1,4]-benzoquinone (DHBQ) with diamines could not be explained satisfactorily so far. In general, the reaction products can be derived from the tautomeric ortho-quinoid structure of a hypothetical 4,5-dihydroxy- [1,2]-benzoquinone. However, both aromatic and aliphatic 1,2-diamines form phenazines, in some cases, formally by diimine formation on the quinoid carbo Read More