Current Organic Chemistry - Volume 25, Issue 14, 2021

Amino acids (AAs) play an important role in the modern health industry. The aim of this article was to assess that AAs’ residues are frequently found in the structures of smallmolecule modern pharmaceuticals, while peptidomimetics and peptide-based drugs are entirely derived from AAs. Currently, AAs serve as key structural features in numerous successful pharmaceuticals, so-called blockbuster drugs. In this work, we pr Read More

The photochemical isomerisation of hexatomic heterocyclic compounds has been discussed. The attention was focused on the mono- and dinitrogen hexatomic heterocycles. To justify the photochemical isomerisation of pyridines, Dewar isomers, azaprismane, and azaprefulvene derivatives have been proposed. The photoisomerisation of pyridinium salts requires a ring reduction with the formation of arizines. Pyri Read More

The topic of this review is the amide-directed functionalization of strained carbocycles - specifically, unsaturated or saturated three- and four-membered rings. The following approaches are discussed: a) directed carbometallation and hydrometallation of cyclopropenes catalyzed by transition metals; b) directed metal-templated nucleophilic addition reactions; c) directed C-H functionalization, including transition meta Read More

Aims: Biological studies have shown that some condensed derivatives of pyrano[3,4- c]pyridines 6 exhibited pronounced biological activity. Considering these results, the principal aim of this work is to study the regiochemistry of the synthesis of pyrano[3,4-c]pyridines 6, to optimize the reaction conditions and thus to increase the previously observed low yields of pyrano[ 3,4-c]pyridines. Background: Within this research l Read More

Aims: Producing novel pyrazolotriazines such as pyrazolo[1,5-a][1,3,5]triazine and pyrazolo[5,1-c][1,2,4]triazine derivatives and evaluate their biological activity as antimicrobial agents followed by the Minimum Inhibitory Concentration (MIC) for the most active compounds. Moreover, study the molecular docking and the RNA polymerase inhibitory activity. Background: Pyrazolotriazine derivatives considered one of the most i Read More