Current Organic Chemistry - Volume 25, Issue 18, 2021

The PdII-mediated cross-coupling of (hetero)arenes with alkenes may be an effective method for the formation of a C–C bond from two C–H bonds. This reaction was discovered by Fujiwara and his co-workers in 1967, which led to a number of reports that we first highlighted in 2011 (review with references till June 2010) and for which we retained the name “Dehydrogenative Heck Reaction” (DHR). The DHR of six-membered hete Read More

Selenium-containing heteroarenes consist of a synthetically valuable family of compounds that found applications in many different areas, such as organic synthesis, medicinal chemistry, supramolecular chemistry, and optoelectronic devices construction. Over the past decade, many advances have been achieved to the synthesis of these substances, and this review aims to cover a literature survey of the direct selenylation of h Read More

The use of F-based decorations in drug discovery started from the development of fluorocorticoids and fluorochinolones (1950s and 1980s respectively) and it resulted in about 20% of approved drugs on the Market containing fluorine. From a medicinal chemistry perspective, the installation of F-based small groups (e.g. -CF3, -CF2H, -OCF3, -OCF2H, -SCF3, - SCF2H) necessarily impacts on physicochemical, pharmac Read More

The functionalization of a Csp2-H bond of an heteroarene with an alkyne represent one of the most attractive procedure for the late-stage functionalization of the aromatic core, due to the structural characteristics and synthetic versatility given by a triple carbon-carbon bond. The aim of this review is to cover the most significant results reported in the literature regarding the synthesis of alkynyl-substituted five-membe Read More

Coumarin-based derivatives have easy modification and tunable properties and have been synthesized and applied in many areas including pro-drugs, biomedical materials, and chemical and biological sensing. In this review, recent advances of coumarin-based fluorescent probes for biosensing are reported for metal ion imaging. Metal detection in living cells are highlighted with representative examples together with Read More