Current Organic Chemistry - Volume 25, Issue 16, 2021

Aliphatic secondary and tertiary amines are widely used in the production of pharmaceuticals, agrochemicals, dyes, surfactants and rubber chemicals. Most traditional synthetic methods are often unsuitable for large-scale production due to poor selectivity, harsh reaction conditions and the cost of starting materials. In this context, hydroaminomethylation (HAM) is a very attractive catalytic process with high atom econo Read More

Nowadays, boron-containing compounds have gained researchers’ attention because of the wide versatility and applicability of this element in both organic and medicinal chemistry. Since its discovery, its use in medicinal chemistry was neglected because of its possible toxic effects. However, in the past years, boron-containing compounds did not show such effects, and some drugs have already been approved by the Food and D Read More

Aziridines are the saturated three-membered cyclic amines that constitute an important group of synthetic intermediates. These could act as a precursor for diverse organic compounds owing to the reactivity due to the ring strain associated with them. The outstanding property of aziridines is their high reactivity towards various nucleophilic and electrophilic reagents to acquire more stable ring-opened or ring-expanded amin Read More

In the last few decades, urea derivatives have gained significant importance due to its wide applications in pharmaceutical, polymer, dyes, and agriculture industries. Urea derivatives are the key starting material for the synthesis of novel bioactive heterocyclic molecules. Substituted urea derivatives are known to possess a wide array of biological activities such as herbicidal, antimicrobial, antimalarial, antivirus, anticancer, Read More

Cyclodextrin (CD) polymers are covalently linked hollow structures that are a network of less flexible macrocycles. They can be divided into two main groups: a) soluble (CDPS); and b) insoluble (CDPIS) polymers. These two types are generally prepared in a similar reaction, and the CD/reagent ratio determines the final properties of the reaction product. Changing this ratio of the generally bifunctionalized crosslinkin Read More