Current Organic Chemistry - Volume 25, Issue 12, 2021

Carbon-carbon bond formation is the essence of organic synthesis, and for that, many strategies have been developed to accomplish this goal. Several of these strategies are conducted to form diverse structures bearing the α,α-diarylcarbonyl motif, in the form of 1,2,2-triarylethanones, which are unities present in a number of natural products and biologically active compounds. These privileged carbonyl compounds hav Read More

Background: N,N'-Diacylhydrazines are involved in many synthetic transformations. The current work reviews the synthesis of N,N'-diacylhydrazines and their use in various synthetic transformations. Results: Three synthetic routes are commonly used to produce N,N'-diacylhydrazines. They are produced through the coupling of acyl chlorides and carbohydrazides, the reaction of hydrazine hydrate and carboxylic acids or isocyan Read More

Natural compounds are the prominent sources for the synthesis of abundant biologically active substances in medicinal chemistry. Camphor exists in two enantiomeric forms i.e., R and S, or both, which are readily obtainable. Camphor is a small molecule with chirality property that binds to some active site, together with its low cost and convenience to transform into synthetically useful derivatives and one of the most impor Read More

The investigation of effective and green synthetic routes to approach to novel fused heterocycles with pyridopyrimidine and pyridopyrazine scaffolds stirs up broad interest from scientists as they are capable of providing valuable properties such as anticancer and antimicrobial activities and they are proved γ-secretase modulators, polymers, and corrosion inhibitors. This causes a steady increase in the number of publica Read More

Background: Synthesis of a series of 2-(dichloromethyl)pyrazolo[1,5- a][1,3,5]triazines was carried out and evaluated in vitro for their anticancer activity against a panel of 60 cell lines derived from nine cancer types. Methods: The joint quantum-chemical and experimental study of the influence of the extended πconjugated phenyl substituents on the electron structure of the pyrazolo[1,5- a][1,3,5]triazines as Pharmaco Read More