Current Organic Chemistry - Volume 25, Issue 10, 2021

Historically, medicinal chemistry has been concerned with the approach of organic chemistry for new drug synthesis. Considering the fruitful collections of new molecular entities, the dedicated efforts for medicinal chemistry are rewarding. Planning and search for new and applicable pharmacologic therapies involve the altruistic nature of the scientists. Since the 19th century, notoriously applying isolated and characte Read More

C-X (X = halogen) bonds are indispensable functional groups in organic synthesis by mediating a massive number of important organic reactions. While a variety of different catalytic strategies are available for generating C-X bonds, those methods enabling the C-X bond formation under transition metal-free conditions via the C-H bond functionalization are particularly interesting because of the inherent atom economy an Read More

Green chemistry is an essential part of the organic synthesis chemistry and plays a principal role in saving the environment from harmful and toxic catalysts. Fruit juice catalyzed chemistry is a vital part of green chemistry in which lemon juice plays a potential role in various organic transformations. This review article summarizes (from 2011-2020) the application and importance of lemon juice in synthetic organic tr Read More

The chemistry and pharmacology of the important Vinca alkaloids such as vinblastine and vincristine used in anticancer therapy are still investigated widely. Several new derivatives, e.g., vinflunine, vinorelbine, and vindesine, have been synthesized and become successful medicines in anti-cancer therapy. In 2012, we published a paper that reviewed the Vinca derivatives. Nevertheless, the interest in the preparation of Read More

In recent years, the development of the chemical industry has been moving in a green, safe and efficient direction. Oxidation reactions are one of the most important types of reactions and have key applications in food, medicine, cosmetics, and petrochemicals. However, the occurrence of the oxidation reaction is accompanied by a strong exothermic phenomenon, and improper control can easily lead to safety problems and ev Read More