Current Cancer Therapy Reviews - Online First

Globally, lung cancer continues to be the primary cause of cancer-related fatalities. Despite significant advancements in chemotherapy, targeted therapy, and immunotherapy that have improved treatment effectiveness and increased survival rates, the five-year relative survival rate for lung cancer patients remains very low. Most cases receive a diagnosis at an advanced stage, which primarily contributes to this. Drug resista Read More

Lung cancer has become one of the leading causes of death worldwide, following cardiovascular disease. It is defined as a disease in which lung cells divide uncontrollably, forming tumors that can either remain localised or spread to other parts of the body. Patients with lung cancer often experience symptoms, such as shortness of breath, pain, and loss of appetite, which can significantly impact their quality of life. Addition Read More

The review paper provides an extensive overview of strategies for targeting the tumour microenvironment (TME) to enhance cancer therapy. It begins by underscoring the importance of profiling and comprehending the TME through advanced technologies like organ chips and artificial intelligence. The paper discusses multiple approaches to modulate the pro-tumour TME, including strategies for eliminating, normalizing Read More

Introduction Cancer-associated venous thromboembolism (VTE) presents a complex clinical challenge, with the need to balance effective anticoagulation against the risk of bleeding. Direct oral anticoagulants (DOACs) offer convenience but their efficacy and safety in this context remain debated. This systematic review and meta-analysis endeavor to evaluate the effectiveness and safety of DOACs in managing VT Read More

Lung cancer is the leading cause of cancer-related deaths globally, necessitating ongoing scientific research to understand its detection, treatment, and prevention. Long non-coding RNAs (lncRNAs) are a diverse group of non-coding RNAs that play crucial roles in regulating tumorigenic processes, such as cell proliferation, invasion, and metastasis in non-small cell lung cancer (NSCLC). Despite not encoding proteins, lncR Read More

The five-year survival rate for people with colon cancer has increased explosively over the last two decades due to major advances in treatment. Colon cancer survival rates have improved significantly over the past few decades, with some of this success owing to aggressive surgical care and breakthroughs in other complementary treatments. As a new option for Colorectal Cancer (CRC) patients, targeted therapy has been sh Read More

Oral cancer treatment frequently results in bone damage and complications such as osteoradionecrosis (ORN) and impeding bone regeneration. Chitosan, a biocompatible and biodegradable natural polymer, demonstrates potential for bone regeneration but suffers from insufficient mechanical strength. MXene, a novel 2D material exhibiting high electrical conductivity and mechanical strength, offers a promising syn Read More

Cancer immunotherapy has proven its potential application by enhancing the capacity of the immune system to destroy cancer cells. However, several challenges, such as non-specific targeting, variability in clinical response, and therapeutic resistance, are associated with immunotherapy, making it less efficacious. Nanoparticles (NPs) as a drug delivery system provide additional advantages during immunotherapy by ensuri Read More