- Home
- A-Z Publications
- Current Cancer Therapy Reviews
- Fast Track Listing
Current Cancer Therapy Reviews - Online First
Description text for Online First listing goes here...
-
-
Modulation of Intestinal Flora as an Emerging Therapeutic Approach for the Treatment of Colon Cancer
Available online: 08 October 2024More LessThe five-year survival rate for people with colon cancer has increased explosively over the last two decades due to major advances in treatment. Colon cancer survival rates have improved significantly over the past few decades, with some of this success owing to aggressive surgical care and breakthroughs in other complementary treatments. As a new option for Colorectal Cancer (CRC) patients, targeted therapy has been shown to be effective in extending the overall life. A dramatic increase in the number of novel drugs targeting multiple key pathways and immunological checkpoints has been observed after the success of cetuximab (an EGFR inhibitor) and bevacizumab (an anti-angiogenic agent). Neutralizing an already present dysbiosis in the gut microbiome is a novel strategy for combating colorectal cancer and its metastases. Several methods have been employed to date, such as prebiotics, postbiotics, antibiotics, and the transplantation of faecal microbiota. An overview of the epidemiological study and possible mechanisms of colon cancer is presented in this review. We have covered a wide range of targeted treatments for CRC in addition to diagnostic biomarkers as therapeutic targets.
-
-
-
Chitosan/MXene Composite Scaffolds for Bone Regeneration in Oral Cancer Treatment - A Review
Authors: Sesuraj Balasamy, Dhanraj Ganapathy, Raji Atchudan, Sandeep Arya and Ashok K. SundramoorthyAvailable online: 02 October 2024More LessOral cancer treatment frequently results in bone damage and complications such as osteoradionecrosis (ORN) and impeding bone regeneration. Chitosan, a biocompatible and biodegradable natural polymer, demonstrates potential for bone regeneration but suffers from insufficient mechanical strength. MXene, a novel 2D material exhibiting high electrical conductivity and mechanical strength, offers a promising synergistic solution. This review explores the potential of chitosan-MXene composite scaffolds for bone regeneration within the context of oral cancer treatment. The advantages of these composites are discussed, including enhanced mechanical strength, electrical stimulation of bone cell activity, controlled drug delivery, and improved biocompatibility. Various synthesis methods for chitosan/MXene scaffolds are examined, highlighting their advantages and limitations. Critical aspects of biocompatibility and cytotoxicity of these materials are also addressed. The review concludes by delving into the future prospects of chitosan/MXene composites, encompassing tailored scaffold designs, enhanced bioactivity, improved electrical stimulation, and the development of multifunctional and bioresorbable scaffolds. This research holds significant promise for enhancing treatment outcomes and improving the quality of life for oral cancer patients.
-
-
-
Platelets in Cancer: From Hemostasis to Metastasis: A Review
Authors: Satyam Yadav, Ravi Ranjan and Ranjeet KumarAvailable online: 11 September 2024More LessPlatelets are small anucleated blood cells that play a vital role in preserving the integrity of tissue because of their hemostatic properties. However, through their interactions with leukocytes, they also have important functions in immunological responses and inflammation. Platelets have an impact on the tumor's development and metastasis at different stages of cancer. They promote angiogenesis and metastasis by modifying endothelial activation, improving leukocyte migration to tumor locations, and changing inflammatory conditions. Patients with cancer frequently have aberrant platelet activity, which accelerates the progression of the illness. Tumor cells that penetrate the bloodstream stimulate platelets, which causes the tumor cells to take on a mesenchymal-like phenotype and widen the permeability of the endothelium. As a result, tumor cell-platelet emboli are created. In addition, platelets draw in myeloid cells, shield tumor cells from immunological reactions and shear stress, and aid in their extravasation into distant organs. Ultimately, growth factors derived from platelets help create micrometastatic foci. With an emphasis on current advancements in the area, this review clarifies the intricate mechanisms of platelet activation and their interactions with cancer cells.
-
-
-
Unveiling The Applications of Nanoparticles in Cancer Immunotherapy
Authors: Gulpreet Mehra, Pragya Singh and Nitin SharmaAvailable online: 11 September 2024More LessCancer immunotherapy has proven its potential application by enhancing the capacity of the immune system to destroy cancer cells. However, several challenges, such as non-specific targeting, variability in clinical response, and therapeutic resistance, are associated with immunotherapy, making it less efficacious. Nanoparticles (NPs) as a drug delivery system provide additional advantages during immunotherapy by ensuring targeted delivery of antigens. NPs can also change the cancer environment through adjuvant delivery, forcing cancer cells to be destroyed. Here, several applications of NPs are summarized to help enhance the therapeutic values of immunotherapy through several mechanisms. This article outlines the important developments and possible applications of NPs to fully realize the promise of cancer immunotherapy, which will eventually open the door to more personalized and efficient cancer treatments.
-