Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Current Cancer Therapy Reviews
  4. Fast Track Articles
  5. Fast Track Article
image of Platelets in Cancer: From Hemostasis to Metastasis: A Review

Abstract

Platelets are small anucleated blood cells that play a vital role in preserving the integrity of tissue because of their hemostatic properties. However, through their interactions with leukocytes, they also have important functions in immunological responses and inflammation. Platelets have an impact on the tumor's development and metastasis at different stages of cancer. They promote angiogenesis and metastasis by modifying endothelial activation, improving leukocyte migration to tumor locations, and changing inflammatory conditions. Patients with cancer frequently have aberrant platelet activity, which accelerates the progression of the illness. Tumor cells that penetrate the bloodstream stimulate platelets, which causes the tumor cells to take on a mesenchymal-like phenotype and widen the permeability of the endothelium. As a result, tumor cell-platelet emboli are created. In addition, platelets draw in myeloid cells, shield tumor cells from immunological reactions and shear stress, and aid in their extravasation into distant organs. Ultimately, growth factors derived from platelets help create micrometastatic foci. With an emphasis on current advancements in the area, this review clarifies the intricate mechanisms of platelet activation and their interactions with cancer cells.

© 2024 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/cctr/10.2174/0115733947314845240902070425
2024-09-11
2025-04-15

  • From This Site

    /content/journals/cctr/10.2174/0115733947314845240902070425
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. Contursi A. Sacco A. Grande R. Dovizio M. Patrignani P. Platelets as crucial partners for tumor metastasis: From mechanistic aspects to pharmacological targeting. Cell. Mol. Life Sci. 2017 74 19 3491 3507 10.1007/s00018‑017‑2536‑7 28488110
    [Google Scholar]
  2. Smittenaar C.R. Petersen K.A. Stewart K. Moitt N. Cancer incidence and mortality projections in the UK until 2035. Br. J. Cancer 2016 115 9 1147 1155 10.1038/bjc.2016.304 27727232
    [Google Scholar]
  3. Zhou L. Zhang Z. Tian Y. Li Z. Liu Z. Zhu S. The critical role of platelet in cancer progression and metastasis. Eur. J. Med. Res. 2023 28 1 385 10.1186/s40001‑023‑01342‑w 37770941
    [Google Scholar]
  4. Després J.P. Body fat distribution and risk of cardiovascular disease: An update. Circulation 2012 126 10 1301 1313 10.1161/CIRCULATIONAHA.111.067264 22949540
    [Google Scholar]
  5. Rothwell P.M. Wilson M. Elwin C.E. Norrving B. Algra A. Warlow C.P. Meade T.W. Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials. Lancet 2010 376 9754 1741 1750 10.1016/S0140‑6736(10)61543‑7 20970847
    [Google Scholar]
  6. Patrignani P. Patrono C. Aspirin and Cancer. J. Am. Coll. Cardiol. 2016 68 9 967 976 10.1016/j.jacc.2016.05.083 27561771
    [Google Scholar]
  7. Dovizio M. Alberti S. Guillem-Llobat P. Patrignani P. Role of platelets in inflammation and cancer: Novel therapeutic strategies. Basic Clin. Pharmacol. Toxicol. 2014 114 1 118 127 10.1111/bcpt.12156 24118902
    [Google Scholar]
  8. Best M.G. Sol N. Kooi I. Tannous J. Westerman B.A. Rustenburg F. Schellen P. Verschueren H. Post E. Koster J. Ylstra B. Ameziane N. Dorsman J. Smit E.F. Verheul H.M. Noske D.P. Reijneveld J.C. Nilsson R.J.A. Tannous B.A. Wesseling P. Wurdinger T. RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics. Cancer Cell 2015 28 5 666 676 10.1016/j.ccell.2015.09.018 26525104
    [Google Scholar]
  9. Nilsson R.J.A. Balaj L. Hulleman E. van Rijn S. Pegtel D.M. Walraven M. Widmark A. Gerritsen W.R. Verheul H.M. Vandertop W.P. Noske D.P. Skog J. Würdinger T. Blood platelets contain tumor-derived RNA biomarkers. Blood 2011 118 13 3680 3683 10.1182/blood‑2011‑03‑344408 21832279
    [Google Scholar]
  10. Li Z. Delaney M.K. O’Brien K.A. Du X. Signaling during platelet adhesion and activation. Arterioscler. Thromb. Vasc. Biol. 2010 30 12 2341 2349 10.1161/ATVBAHA.110.207522 21071698
    [Google Scholar]
  11. Simmons D.L. Botting R.M. Hla T. Cyclooxygenase isozymes: The biology of prostaglandin synthesis and inhibition. Pharmacol. Rev. 2004 56 3 387 437 10.1124/pr.56.3.3 15317910
    [Google Scholar]
  12. Rivera J. Lozano M.L. Navarro-Núñez L. Vicente V. Platelet receptors and signaling in the dynamics of thrombus formation. Haematologica 2009 94 5 700 711 10.3324/haematol.2008.003178 19286885
    [Google Scholar]
  13. Garraud O. Cognasse F. Are Platelets Cells? And if Yes, are They Immune Cells? Front. Immunol. 2015 6 FEB 70 10.3389/fimmu.2015.00070 25750642
    [Google Scholar]
  14. Lannan K.L. Sahler J. Kim N. Spinelli S.L. Maggirwar S.B. Garraud O. Cognasse F. Blumberg N. Phipps R.P. Breaking the mold: Transcription factors in the anucleate platelet and platelet-derived microparticles. Front. Immunol. 2015 6 48 10.3389/fimmu.2015.00048 25762994
    [Google Scholar]
  15. Palmblad J. To give and take — life of a platelet. Blood 2009 113 12 2617 2617 10.1182/blood‑2009‑01‑198135 19299653
    [Google Scholar]
  16. Patrignani P. Patrono C. Aspirin, platelet inhibition and cancer prevention. Platelets 2018 29 8 779 785 10.1080/09537104.2018.1492105 29985750
    [Google Scholar]
  17. Gay L.J. Felding-Habermann B. Contribution of platelets to tumour metastasis. Nat. Rev. Cancer 2011 11 2 123 134 10.1038/nrc3004 21258396
    [Google Scholar]
  18. Han X. Guo B. Li Y. Zhu B. Tissue factor in tumor microenvironment: A systematic review. J. Hematol. Oncol. 2014 7 1 54 10.1186/s13045‑014‑0054‑8 25084809
    [Google Scholar]
  19. Adams G.N. Rosenfeldt L. Frederick M. Miller W. Waltz D. Kombrinck K. McElhinney K.E. Flick M.J. Monia B.P. Revenko A.S. Palumbo J.S. Colon Cancer Growth and Dissemination Relies upon Thrombin, Stromal PAR-1, and Fibrinogen. Cancer Res. 2015 75 19 4235 4243 10.1158/0008‑5472.CAN‑15‑0964 26238780
    [Google Scholar]
  20. Queiroz K.C.S. Shi K. Duitman J. Aberson H.L. Wilmink J.W. van Noesel C.J.M. Richel D.J. Spek C.A. Protease‐activated receptor‐1 drives pancreatic cancer progression and chemoresistance. Int. J. Cancer 2014 135 10 2294 2304 10.1002/ijc.28726 24436106
    [Google Scholar]
  21. Chen D. Abrahams J.M. Smith L.M. McVey J.H. Lechler R.I. Dorling A. Regenerative repair after endoluminal injury in mice with specific antagonism of protease activated receptors on CD34+ vascular progenitors. Blood 2008 111 8 4155 4164 10.1182/blood‑2007‑10‑120295 18268094
    [Google Scholar]
  22. Shao B. Wahrenbrock M.G. Yao L. David T. Coughlin S.R. Xia L. Varki A. McEver R.P. Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome. Blood 2011 118 15 4015 4023 10.1182/blood‑2011‑07‑368514 21860019
    [Google Scholar]
  23. Auwerda J. Yuana Y. Osanto S. de Maat M. Sonneveld P. Bertina R. Leebeek F. Microparticle-associated tissue factor activity and venous thrombosis in multiple myeloma. Thromb. Haemost. 2011 105 1 14 20 10.1160/TH10‑03‑0187 21057704
    [Google Scholar]
  24. Melnikova V.O. Mourad-Zeidan A.A. Lev D.C. Bar-Eli M. Platelet-activating factor mediates MMP-2 expression and activation via phosphorylation of cAMP-response element-binding protein and contributes to melanoma metastasis. J. Biol. Chem. 2006 281 5 2911 2922 10.1074/jbc.M508683200 16306050
    [Google Scholar]
  25. Lambert A.W. Pattabiraman D.R. Weinberg R.A. Emerging Biological Principles of Metastasis. Cell 2017 168 4 670 691 10.1016/j.cell.2016.11.037 28187288
    [Google Scholar]
  26. Xiong G. Chen J. Zhang G. Wang S. Kawasaki K. Zhu J. Zhang Y. Nagata K. Li Z. Zhou B.P. Xu R. Hsp47 promotes cancer metastasis by enhancing collagen-dependent cancer cell-platelet interaction. Proc. Natl. Acad. Sci. USA 2020 117 7 3748 3758 10.1073/pnas.1911951117 32015106
    [Google Scholar]
  27. Cedervall J. Hamidi A. Olsson A.K. Platelets, NETs and cancer. Thromb. Res. 2018 164 Suppl. 1 S148 S152 10.1016/j.thromres.2018.01.049 29703474
    [Google Scholar]
  28. Tsubakihara Y. Moustakas A. Epithelial-Mesenchymal Transition and Metastasis under the Control of Transforming Growth Factor β. Int. J. Mol. Sci. 2018 19 11 3672 10.3390/ijms19113672 30463358
    [Google Scholar]
  29. Massagué J. Obenauf A.C. Metastatic colonization by circulating tumour cells. Nature 2016 529 7586 298 306 10.1038/nature17038 26791720
    [Google Scholar]
  30. Guo Y. Cui W. Pei Y. Xu D. Platelets promote invasion and induce epithelial to mesenchymal transition in ovarian cancer cells by TGF-β signaling pathway. Gynecol. Oncol. 2019 153 3 639 650 10.1016/j.ygyno.2019.02.026 30928020
    [Google Scholar]
  31. Labelle M. Begum S. Hynes R.O. Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell 2011 20 5 576 590 10.1016/j.ccr.2011.09.009 22094253
    [Google Scholar]
  32. Lowe K.L. Navarro-Nunez L. Watson S.P. Platelet CLEC-2 and podoplanin in cancer metastasis. Thromb. Res. 2012 129 S30 S37 10.1016/S0049‑3848(12)70013‑0 22682130
    [Google Scholar]
  33. Stoiber D. Assinger A. Platelet-Leukocyte Interplay in Cancer Development and Progression. Cells 2020 9 4 855 10.3390/cells9040855 32244723
    [Google Scholar]
  34. Tao L. Zhang L. Peng Y. Tao M. Li L. Xiu D. Yuan C. Ma Z. Jiang B. Neutrophils assist the metastasis of circulating tumor cells in pancreatic ductal adenocarcinoma. Medicine (Baltimore) 2016 95 39 e4932 10.1097/MD.0000000000004932 27684834
    [Google Scholar]
  35. Miklikova S. Minarik G. Sedlackova T. Plava J. Cihova M. Jurisova S. Kalavska K. Karaba M. Benca J. Smolkova B. Mego M. Inflammation-Based Scores Increase the Prognostic Value of Circulating Tumor Cells in Primary Breast Cancer. Cancers (Basel) 2020 12 5 1134 10.3390/cancers12051134 32369910
    [Google Scholar]
  36. Ward M.P.E. E Kane L. A Norris L. Mohamed B.M. Kelly T. Bates M. Clarke A. Brady N. Martin C.M. Brooks R.D. Brooks D.A. Selemidis S. Hanniffy S. Dixon E.P. A O’Toole S. J O’Leary J. Platelets, immune cells and the coagulation cascade; friend or foe of the circulating tumour cell? Mol. Cancer 2021 20 1 59 10.1186/s12943‑021‑01347‑1 33789677
    [Google Scholar]
  37. Ren J. He J. Zhang H. Xia Y. Hu Z. Loughran P. Billiar T. Huang H. Tsung A. Platelet TLR4-ERK5 Axis Facilitates NET-Mediated Capturing of Circulating Tumor Cells and Distant Metastasis after Surgical Stress. Cancer Res. 2021 81 9 2373 2385 10.1158/0008‑5472.CAN‑20‑3222 33687949
    [Google Scholar]
  38. Rachidi S. Metelli A. Riesenberg B. Wu B.X. Nelson M.H. Wallace C. Paulos C.M. Rubinstein M.P. Garrett-Mayer E. Hennig M. Bearden D.W. Yang Y. Liu B. Li Z. Platelets subvert T cell immunity against cancer via GARP-TGFβ axis. Sci. Immunol. 2017 2 11 eaai7911 10.1126/sciimmunol.aai7911 28763790
    [Google Scholar]
  39. Haemmerle M. Taylor M.L. Gutschner T. Pradeep S. Cho M.S. Sheng J. Lyons Y.M. Nagaraja A.S. Dood R.L. Wen Y. Mangala L.S. Hansen J.M. Rupaimoole R. Gharpure K.M. Rodriguez-Aguayo C. Yim S.Y. Lee J.S. Ivan C. Hu W. Lopez-Berestein G. Wong S.T. Karlan B.Y. Levine D.A. Liu J. Afshar-Kharghan V. Sood A.K. Platelets reduce anoikis and promote metastasis by activating YAP1 signaling. Nat. Commun. 2017 8 1 310 10.1038/s41467‑017‑00411‑z 28827520
    [Google Scholar]
  40. Xu X.R. Carrim N. Neves M.A.D. McKeown T. Stratton T.W. Coelho R.M.P. Lei X. Chen P. Xu J. Dai X. Li B.X. Ni H. Platelets and platelet adhesion molecules: Novel mechanisms of thrombosis and anti-thrombotic therapies. Thromb. J. 2016 14 S1 Suppl. 1 29 10.1186/s12959‑016‑0100‑6 27766055
    [Google Scholar]
  41. Gong L. Mi H.J. Zhu H. Zhou X. Yang H. P-selectin-mediated platelet activation promotes adhesion of non-small cell lung carcinoma cells on vascular endothelial cells under flow. Mol. Med. Rep. 2012 5 4 935 942 10.3892/mmr.2012.760 22266541
    [Google Scholar]
  42. Plantureux L. Mège D. Crescence L. Carminita E. Robert S. Cointe S. Brouilly N. Ezzedine W. Dignat-George F. Dubois C. Panicot-Dubois L. The Interaction of Platelets with Colorectal Cancer Cells Inhibits Tumor Growth but Promotes Metastasis. Cancer Res. 2020 80 2 291 303 10.1158/0008‑5472.CAN‑19‑1181 31727628
    [Google Scholar]
  43. Semple J.W. Italiano J.E. Jr Freedman J. Platelets and the immune continuum. Nat. Rev. Immunol. 2011 11 4 264 274 10.1038/nri2956 21436837
    [Google Scholar]
  44. Haemmerle M. Stone R.L. Menter D.G. Afshar-Kharghan V. Sood A.K. The Platelet Lifeline to Cancer: Challenges and Opportunities. Cancer Cell 2018 33 6 965 983 10.1016/j.ccell.2018.03.002 29657130
    [Google Scholar]
  45. Schumacher D. Strilic B. Sivaraj K.K. Wettschureck N. Offermanns S. Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor. Cancer Cell 2013 24 1 130 137 10.1016/j.ccr.2013.05.008 23810565
    [Google Scholar]
  46. Labelle M. Begum S. Hynes R.O. Platelets guide the formation of early metastatic niches. Proc. Natl. Acad. Sci. USA 2014 111 30 E3053 E3061 10.1073/pnas.1411082111 25024172
    [Google Scholar]
  47. Kerr B.A. McCabe N.P. Feng W. Byzova T.V. Platelets govern pre-metastatic tumor communication to bone. Oncogene 2013 32 36 4319 4324 10.1038/onc.2012.447 23069656
    [Google Scholar]
  48. Jin D.K. Shido K. Kopp H.G. Petit I. Shmelkov S.V. Young L.M. Hooper A.T. Amano H. Avecilla S.T. Heissig B. Hattori K. Zhang F. Hicklin D.J. Wu Y. Zhu Z. Dunn A. Salari H. Werb Z. Hackett N.R. Crystal R.G. Lyden D. Rafii S. Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes. Nat. Med. 2006 12 5 557 567 10.1038/nm1400 16648859
    [Google Scholar]
  49. Bambace N.M. Holmes C.E. The platelet contribution to cancer progression. J. Thromb. Haemost. 2011 9 2 237 249 10.1111/j.1538‑7836.2010.04131.x 21040448
    [Google Scholar]
  50. Schlesinger M. Role of platelets and platelet receptors in cancer metastasis. J. Hematol. Oncol. 2018 11 1 125 10.1186/s13045‑018‑0669‑2 30305116
    [Google Scholar]
  51. Schwertz H. Rowley J.W. Tolley N.D. Campbell R.A. Weyrich A.S. Assessing Protein Synthesis by Platelets. Platelets and Megakaryocytes Berlin, Heidelberg Springer Link 2012 10.1007/978‑1‑61779‑307‑3_11
    [Google Scholar]
  52. Ho-Tin-Noé B. Carbo C. Demers M. Cifuni S.M. Goerge T. Wagner D.D. Innate immune cells induce hemorrhage in tumors during thrombocytopenia. Am. J. Pathol. 2009 175 4 1699 1708 10.2353/ajpath.2009.090460 19729481
    [Google Scholar]
  53. Cohen JD Li L Wang Y Thoburn C Afsari B Danilova L Detection and localization of surgically resectable cancers with a multi-analyte blood test. Science 2018 359 6378 926 930
    [Google Scholar]
  54. Contursi A. Grande R. Dovizio M. Bruno A. Fullone R. Patrignani P. Platelets in cancer development and diagnosis. Biochem. Soc. Trans. 2018 46 6 1517 1527 10.1042/BST20180159 30420412
    [Google Scholar]
  55. Sabrkhany S. Kuijpers M.J.E. Knol J.C. Olde Damink S.W.M. Dingemans A.M.C. Verheul H.M. Piersma S.R. Pham T.V. Griffioen A.W. oude Egbrink M.G.A. Jimenez C.R. Exploration of the platelet proteome in patients with early-stage cancer. J. Proteomics 2018 177 65 74 10.1016/j.jprot.2018.02.011 29432918
    [Google Scholar]
  56. Peterson J.E. Zurakowski D. Italiano J.E. Jr Michel L.V. Connors S. Oenick M. D’Amato R.J. Klement G.L. Folkman J. VEGF, PF4 and PDGF are elevated in platelets of colorectal cancer patients. Angiogenesis 2012 15 2 265 273 10.1007/s10456‑012‑9259‑z 22402885
    [Google Scholar]
  57. Burkhart J.M. Gambaryan S. Watson S.P. Jurk K. Walter U. Sickmann A. Heemskerk J.W.M. Zahedi R.P. What can proteomics tell us about platelets? Circ. Res. 2014 114 7 1204 1219 10.1161/CIRCRESAHA.114.301598 24677239
    [Google Scholar]
  58. Lomnytska M. Pinto R. Becker S. Engström U. Gustafsson S. Björklund C. Templin M. Bergstrand J. Xu L. Widengren J. Epstein E. Franzén B. Auer G. Platelet protein biomarker panel for ovarian cancer diagnosis. Biomark. Res. 2018 6 1 2 10.1186/s40364‑018‑0118‑y 29344361
    [Google Scholar]
  59. Futakuchi M. Ogawa K. Sano M. Tamano S. Takeshita F. Shirai T. Suppression of lung metastasis by aspirin but not indomethacin in an in vivo model of chemically induced hepatocellular carcinoma. Jpn. J. Cancer Res. 2002 93 10 1175 1181 10.1111/j.1349‑7006.2002.tb01220.x 12417048
    [Google Scholar]
  60. Jacobs C.D. Chun S.G. Yan J. Xie X.J. Pistenmaa D.A. Hannan R. Lotan Y. Roehrborn C.G. Choe K.S. Kim D.W.N. Aspirin improves outcome in high risk prostate cancer patients treated with radiation therapy. Cancer Biol. Ther. 2014 15 6 699 706 10.4161/cbt.28554 24658086
    [Google Scholar]
  61. Shiao J. Thomas K.M. Rahimi A.S. Rao R. Yan J. Xie X.J. DaSilva M. Spangler A. Leitch M. Wooldridge R. Rivers A. Farr D. Haley B. Kim D.W.N. Aspirin/antiplatelet agent use improves disease-free survival and reduces the risk of distant metastases in Stage II and III triple-negative breast cancer patients. Breast Cancer Res. Treat. 2017 161 3 463 471 10.1007/s10549‑016‑4081‑8 28005245
    [Google Scholar]
  62. Holmes M.D. Chen W.Y. Li L. Hertzmark E. Spiegelman D. Hankinson S.E. Aspirin intake and survival after breast cancer. J. Clin. Oncol. 2010 28 9 1467 1472 10.1200/JCO.2009.22.7918 20159825
    [Google Scholar]
  63. Hua H. Zhang H. Kong Q. Wang J. Jiang Y. Complex roles of the old drug aspirin in cancer chemoprevention and therapy. Med. Res. Rev. 2019 39 1 114 145 10.1002/med.21514 29855050
    [Google Scholar]
  64. Guillem-Llobat P. Dovizio M. Bruno A. Ricciotti E. Cufino V. Sacco A. Grande R. Alberti S. Arena V. Cirillo M. Patrono C. FitzGerald G.A. Steinhilber D. Sgambato A. Patrignani P. Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells. Oncotarget 2016 7 22 32462 32477 10.18632/oncotarget.8655 27074574
    [Google Scholar]
  65. Rothwell P.M. Fowkes F.G.R. Belch J.F.F. Ogawa H. Warlow C.P. Meade T.W. Effect of daily aspirin on long-term risk of death due to cancer: Analysis of individual patient data from randomised trials. Lancet 2011 377 9759 31 41 10.1016/S0140‑6736(10)62110‑1 21144578
    [Google Scholar]
  66. Battinelli E.M. Markens B.A. Kulenthirarajan R.A. Machlus K.R. Flaumenhaft R. Italiano J.E. Jr Anticoagulation inhibits tumor cell–mediated release of platelet angiogenic proteins and diminishes platelet angiogenic response. Blood 2014 123 1 101 112 10.1182/blood‑2013‑02‑485011 24065244
    [Google Scholar]
  67. Sitia G. Aiolfi R. Di Lucia P. Mainetti M. Fiocchi A. Mingozzi F. Esposito A. Ruggeri Z.M. Chisari F.V. Iannacone M. Guidotti L.G. Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B. Proc. Natl. Acad. Sci. USA 2012 109 32 E2165 E2172 10.1073/pnas.1209182109 22753481
    [Google Scholar]
  68. Amirkhosravi A. Mousa S.A. Amaya M. Blaydes S. Desai H. Meyer T. Francis J.L. Inhibition of tumor cell-induced platelet aggregation and lung metastasis by the oral GpIIb/IIIa antagonist XV454. Thromb. Haemost. 2003 90 3 549 554 12958625
    [Google Scholar]
  69. Boukerche H. Berthier-Vergnes O. Tabone E. Doré J.F. Leung L.L. McGregor J.L. Platelet-melanoma cell interaction is mediated by the glycoprotein IIb- IIIa complex. Blood 1989 74 2 658 663 10.1182/blood.V74.2.658.658 2752140
    [Google Scholar]
  70. Dovizio M. Maier T.J. Alberti S. Di Francesco L. Marcantoni E. Münch G. John C.M. Suess B. Sgambato A. Steinhilber D. Patrignani P. Pharmacological inhibition of platelet-tumor cell cross-talk prevents platelet-induced overexpression of cyclooxygenase-2 in HT29 human colon carcinoma cells. Mol. Pharmacol. 2013 84 1 25 40 10.1124/mol.113.084988 23580446
    [Google Scholar]
  71. Free S.R. Carraway K.L. Platelets in Hematogenous Breast Cancer Metastasis: Partners in Crime. Breast Cancer. Australia Exon Publications 2022 101 114 10.36255/exon‑publications‑breast‑cancer‑platelets
    [Google Scholar]
  72. Elaskalani O. Berndt M. Falasca M. Metharom P. Targeting Platelets for the Treatment of Cancer. Cancers (Basel) 2017 9 7 94 10.3390/cancers9070094 28737696
    [Google Scholar]
  73. Stoletov K. Beatty P.H. Lewis J.D. Novel therapeutic targets for cancer metastasis. Expert Rev. Anticancer Ther. 2020 20 2 97 109 10.1080/14737140.2020.1718496 31997674
    [Google Scholar]
  74. Liao K Zhang X Liu J Teng F He Y Cheng J The role of platelets in the regulation of tumor growth and metastasis: The mechanisms and targeted therapy. MedComm 2023 4 5 e350 10.1002/mco2.350
    [Google Scholar]
/content/journals/cctr/10.2174/0115733947314845240902070425
Loading
Platelets in Cancer: From Hemostasis to Metastasis: A Review
Bentham Science Publishers ; https://doi.org/10.2174/0115733947314845240902070425
/content/journals/cctr/10.2174/0115733947314845240902070425
/content/journals/cctr/10.2174/0115733947314845240902070425
Loading

Data & Media loading...


  • Article Type:     Review Article
Keywords: growth factors ; anti-platelet drugs ; cancer ; Tumor ; platelets ; metastasis

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test