Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Current Cancer Therapy Reviews
  4. Fast Track Articles
  5. Fast Track Article
image of Current Developments in Palliative Care for Patients with Lung Cancer

Abstract

Lung cancer has become one of the leading causes of death worldwide, following cardiovascular disease. It is defined as a disease in which lung cells divide uncontrollably, forming tumors that can either remain localised or spread to other parts of the body. Patients with lung cancer often experience symptoms, such as shortness of breath, pain, and loss of appetite, which can significantly impact their quality of life. Additionally, the treatment of lung cancer, particularly chemotherapy, can cause severe adverse effects. Risk factors, such as smoking, and alcohol consumption, can increase the likelihood of developing lung cancer. Therefore, it is essential to provide palliative care to all lung cancer patients to manage their symptoms and improve their quality of life. Simply relying on curative treatments, like chemotherapy and radiation therapy, may not be enough to achieve therapeutic goals. Effective communication between healthcare professionals and patients is crucial in ensuring that appropriate palliative care is provided. Misunderstandings can arise if there are gaps in communication between patients and healthcare professionals, leading to suboptimal care plans. Unfortunately, palliative care services are still not widely known or easily accessible. More research is needed to promote and expand access to palliative care services for patients with lung cancer. This review summarises the etiological factors, consequences, symptoms management, and the beneficial role of palliative care in surgery, chemotherapy, and radiotherapy for lung cancer patients. It also discusses implications for practice and research, as well as challenges in palliative and end-of-life care for these patients.

© 2025 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/cctr/10.2174/0115733947346619241219100104
2025-01-22
2025-06-23

  • From This Site

    /content/journals/cctr/10.2174/0115733947346619241219100104
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. Cancer 2022 https://www.who.int/news-room/fact-sheets/detail/lung-cancer
  2. Temel J.S. Petrillo L.A. Greer J.A. Patient-centered palliative care for patients with advanced lung cancer. J. Clin. Oncol. 2022 40 6 626 634 10.1200/JCO.21.01710 34985932
    [Google Scholar]
  3. Bade B.C. Dela Cruz C.S. Lung cancer 2020. Clin. Chest Med. 2020 41 1 1 24 10.1016/j.ccm.2019.10.001 32008623
    [Google Scholar]
  4. Yates P Schofield P Zhao I Currow D Supportive and palliative care for lung cancer patients. J Thorac Dis. 2013 5 5 623 628 10.3978/j.issn.2072‑1439.2013.10.05
    [Google Scholar]
  5. Smith S. Sapkaroski D. Brand M. Tran A. Zalcberg J. Stirling R.G. Mapping the clinical care pathways for advanced stage non‐small cell lung cancer patients in Victoria: A retrospective cohort study of supportive and palliative care. Nurs. Health Sci. 2023 25 3 411 423 10.1111/nhs.13044 37562814
    [Google Scholar]
  6. He Y. Sun L.Y. Peng K.W. Luo M.J. Deng L. Tang T. You C.X. Sleep quality, anxiety and depression in advanced lung cancer: Patients and caregivers. BMJ Support. Palliat. Care 2022 12 e2 e194 e200 10.1136/bmjspcare‑2018‑001684 32253349
    [Google Scholar]
  7. Lo S.B. Ruprecht A.L. Post K.E. Eche-Ugwu I.J. Cooley M.E. Temel J.S. Greer J.A. Dyspnea-related dimensions and self-efficacy: Associations with well-being in advanced lung cancer. J. Pain Symptom Manage. 2024 67 5 366 374.e1 10.1016/j.jpainsymman.2024.01.032 38307373
    [Google Scholar]
  8. Wolyniec K. Sharp J. Fisher K. Tothill R.W. Bowtell D. Mileshkin L. Schofield P. Psychological distress, understanding of cancer and illness uncertainty in patients with cancer of unknown primary. Psychooncology 2022 31 11 1869 1876 10.1002/pon.5990 35765251
    [Google Scholar]
  9. World Health Organization. Palliative Care 2020 https://www.who.int/en/news-room/fact-sheets/detail/palliative-care
  10. Zemplényi A.T. Csikós Á. Fadgyas-Freyler P. Csanádi M. Kaló Z. Pozsgai É. Rutten-van Mölken M. Pitter J.G. Early palliative care associated with lower costs for adults with advanced cancer: Evidence from Hungary. Eur. J. Cancer Care (Engl.) 2021 30 6 e13473 10.1111/ecc.13473 34106508
    [Google Scholar]
  11. Zaborowski N. Scheu A. Glowacki N. Lindell M. Battle-Miller K. Early palliative care consults reduce patients length of stay and overall hospital costs. Am. J. Hosp. Palliat. Care 2022 39 11 1268 1273 10.1177/10499091211067811 35061508
    [Google Scholar]
  12. Hudson P. Girgis A. Thomas K. Philip J. Currow D.C. Mitchell G. Parker D. Liew D. Brand C. Le B. Moran J. Do family meetings for hospitalised palliative care patients improve outcomes and reduce health care costs? A cluster randomised trial. Palliat. Med. 2021 35 1 188 199 10.1177/0269216320967282 33135552
    [Google Scholar]
  13. Haun M.W. Estel S. Rücker G. Friederich H.C. Villalobos M. Thomas M. Hartmann M. Early palliative care for adults with advanced cancer. Cochrane Libr. 2017 2017 6 CD011129 10.1002/14651858.CD011129.pub2 28603881
    [Google Scholar]
  14. Hanna N. Shepherd F.A. Fossella F.V. Pereira J.R. De Marinis F. von Pawel J. Gatzemeier U. Tsao T.C.Y. Pless M. Muller T. Lim H.L. Desch C. Szondy K. Gervais R. Shaharyar Manegold C. Paul S. Paoletti P. Einhorn L. Bunn P.A. Jr Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy. J. Clin. Oncol. 2004 22 9 1589 1597 10.1200/JCO.2004.08.163 15117980
    [Google Scholar]
  15. van der Bruggen W. Arens A.I. van der Drift M.A. de Geus-Oei L.F. Gotthardt M. Oyen W.J. Referred shoulder pain in a patient with small cell lung cancer. Adrenal gland metastases. Neth. J. Med. 2013 71 4 203 206 23723115
    [Google Scholar]
  16. Mantyh P.W. Clohisy D.R. Koltzenburg M. Hunt S.P. Molecular mechanisms of cancer pain. Nat. Rev. Cancer 2002 2 3 201 209 10.1038/nrc747 11990856
    [Google Scholar]
  17. Kapo J.M. Akgün K.M. Integrating palliative care into the care of patients with advanced lung cancer. Cancer J. 2015 21 5 434 439 10.1097/PPO.0000000000000149 26389769
    [Google Scholar]
  18. Hui D. Bohlke K. Bao T. Campbell T.C. Coyne P.J. Currow D.C. Gupta A. Leiser A.L. Mori M. Nava S. Reinke L.F. Roeland E.J. Seigel C. Walsh D. Campbell M.L. Management of dyspnea in advanced cancer: ASCO guideline. J. Clin. Oncol. 2021 39 12 1389 1411 10.1200/JCO.20.03465 33617290
    [Google Scholar]
  19. Kocatepe V. Can G. Oruç Ö. Lung cancer–related dyspnea: The effects of a handheld fan on management of symptoms. Clin. J. Oncol. Nurs. 2021 25 6 655 661 10.1188/21.CJON.655‑661 34800099
    [Google Scholar]
  20. Julià-Torras J. Almeida Felipe J.M. Gándara del Castillo Á. González-Barboteo J. Forero D. Alegre S. Cuervo-Pinna M.Á. Serna J. Muñoz-Unceta N. Alonso-Babarro A. Miró Catalina Q. Moreno-Alonso D. Porta-Sales J. Prevalence, clinical characteristics, and management of episodic dyspnea in advanced lung cancer outpatients: A multicenter nationwide study-The INSPIRA-DOS study. J. Palliat. Med. 2022 25 8 1197 1207 10.1089/jpm.2021.0562 35196465
    [Google Scholar]
  21. Molassiotis A. Yates P. Yorke J. Editorial: Quality of life and side effects management in lung cancer treatment. Front. Oncol. 2021 11 651797 10.3389/fonc.2021.651797 33747969
    [Google Scholar]
  22. Shin J. Bush N.J. Integration of behavioral cough suppression therapy into lung cancer care: Nonpharmacologic interventions for chronic cough. Clin. J. Oncol. Nurs. 2022 26 1 40 47 10.1188/22.CJON.40‑47 35073303
    [Google Scholar]
  23. Lim R.B.L. End-of-life care in patients with advanced lung cancer. Ther. Adv. Respir. Dis. 2016 10 5 455 467 27585597
    [Google Scholar]
  24. 25. Anorexia/Cachexia 2023 http://www.palliativecareguidelines.scot.nhs.uk/guidelines/symptom-control/anorexiacachexia.aspx
  25. Ahlberg K. Ekman T. Gaston-Johansson F. Mock V. Assessment and management of cancer-related fatigue in adults. Lancet 2003 362 9384 640 650 10.1016/S0140‑6736(03)14186‑4 12944066
    [Google Scholar]
  26. Takahashi S. Matsumoto K. Ohba K. Nakano Y. Miyazawa Y. Kawaguchi T. The Incidence and management of cancer-related anorexia during treatment with vascular endothelial growth factor receptor-tyrosine kinase inhibitors. Cancer Manag. Res. 2023 15 1033 1046 10.2147/CMAR.S417238 37771675
    [Google Scholar]
  27. Del Fabbro E. Current and future care of patients with the cancer anorexia-cachexia syndrome. Am. Soc. Clin. Oncol. Educ. Book 2015 ••• 35 e229 e237 10.14694/EdBook_AM.2015.35.e229 25993178
    [Google Scholar]
  28. Zhu R. Liu Z. Jiao R. Zhang C. Yu Q. Han S. Duan Z. Updates on the pathogenesis of advanced lung cancer‐induced cachexia. Thorac. Cancer 2019 10 1 8 16 10.1111/1759‑7714.12910 30461213
    [Google Scholar]
  29. Del Ferraro C Grant M Koczywas M Dorr-Uyemura LA Management of anorexia-cachexia in late stage lung cancer patients. J Hosp Palliat Nurs. 2012 14 6 10.1097/NJH.0b013e31825f3470
    [Google Scholar]
  30. Doshita K. Naito T. Matsuda S. Morita M. Sekikawa M. Miura K. Kodama H. Yabe M. Morikawa N. Iida Y. Mamesaya N. Kobayashi H. Ko R. Wakuda K. Ono A. Murakami H. Kenmotsu H. Takahashi T. Exploring the relationship between anorexia and therapeutic efficacy in advanced lung cancer treatment: A retrospective study. Thorac. Cancer 2024 15 25 1831 1841 10.1111/1759‑7714.15403 39075850
    [Google Scholar]
  31. Tang W.R. Chen W.J. Yu C.T. Chang Y.C. Chen C.M. Wang C.H. Yang S.H. Effects of acupressure on fatigue of lung cancer patients undergoing chemotherapy: An experimental pilot study. Complement. Ther. Med. 2014 22 4 581 591 10.1016/j.ctim.2014.05.006 25146059
    [Google Scholar]
  32. Wagner L.I. Cella D. Fatigue and cancer: Causes, prevalence and treatment approaches. Br. J. Cancer 2004 91 5 822 828 10.1038/sj.bjc.6602012 15238987
    [Google Scholar]
  33. Carroll J.K. Kohli S. Mustian K.M. Roscoe J.A. Morrow G.R. Pharmacologic treatment of cancer-related fatigue. Oncologist 2007 12 S1 Suppl. 1 43 51 10.1634/theoncologist.12‑S1‑43 17573455
    [Google Scholar]
  34. Minton O. Richardson A. Sharpe M. Hotopf M. Stone P. A systematic review and meta-analysis of the pharmacological treatment of cancer-related fatigue. J. Natl. Cancer Inst. 2008 100 16 1155 1166 10.1093/jnci/djn250 18695134
    [Google Scholar]
  35. Bower J.E. Cancer-related fatigue—mechanisms, risk factors, and treatments. Nat. Rev. Clin. Oncol. 2014 11 10 597 609 10.1038/nrclinonc.2014.127 25113839
    [Google Scholar]
  36. Mücke M. Mochamat Cuhls H. Peuckmann-Post V. Minton O. Stone P. Radbruch L. Pharmacological treatments for fatigue associated with palliative care: Executive summary of a cochrane collaboration systematic review. J. Cachexia Sarcopenia Muscle 2016 7 1 23 27 10.1002/jcsm.12101 27066315
    [Google Scholar]
  37. Gong S. Sheng P. Jin H. He H. Qi E. Chen W. Dong Y. Hou L. Effect of methylphenidate in patients with cancer-related fatigue: A systematic review and meta-analysis. PLoS One 2014 9 1 e84391 10.1371/journal.pone.0084391 24416225
    [Google Scholar]
  38. Minton O. Richardson A. Sharpe M. Hotopf M. Stone P.C. Psychostimulants for the management of cancer-related fatigue: A systematic review and meta-analysis. J. Pain Symptom Manage. 2011 41 4 761 767 10.1016/j.jpainsymman.2010.06.020 21251796
    [Google Scholar]
  39. Minton O. Richardson A. Sharpe M. Hotopf M. Stone P. Drug therapy for the management of cancer-related fatigue. Cochrane Libr. 2010 2013 12 CD006704 10.1002/14651858.CD006704.pub3 20614448
    [Google Scholar]
  40. Campos M.P.O. Hassan B.J. Riechelmann R. Del Giglio A. Cancer-related fatigue: A practical review. Ann. Oncol. 2011 22 6 1273 1279 10.1093/annonc/mdq458 21325448
    [Google Scholar]
  41. Cramp F. Byron-Daniel J. Exercise for the management of cancer-related fatigue in adults. Cochrane Libr. 2012 2021 9 CD006145 10.1002/14651858.CD006145.pub3 23152233
    [Google Scholar]
  42. Escalante CP Manzullo EF Cancer-related fatigue: The approach and treatment. J Gen Intern Med. 2009 2 2 412 416 10.1007/s11606‑009‑1056‑z
    [Google Scholar]
  43. Finnegan-John J. Molassiotis A. Richardson A. Ream E. A systematic review of complementary and alternative medicine interventions for the management of cancer-related fatigue. Integr. Cancer Ther. 2013 12 4 276 290 10.1177/1534735413485816 23632236
    [Google Scholar]
  44. Sood A. Barton D.L. Bauer B.A. Loprinzi C.L. A critical review of complementary therapies for cancer-related fatigue. Integr. Cancer Ther. 2007 6 1 8 13 10.1177/1534735406298143 17351022
    [Google Scholar]
  45. Zeng Y. Luo T. Finnegan-John J. Cheng A.S.K. Meta-analysis of randomized controlled trials of acupuncture for cancer-related fatigue. Integr. Cancer Ther. 2014 13 3 193 200 10.1177/1534735413510024 24282102
    [Google Scholar]
  46. Posadzki P. Moon T.W. Choi T.Y. Park T.Y. Lee M.S. Ernst E. Acupuncture for cancer-related fatigue: A systematic review of randomized clinical trials. Support. Care Cancer 2013 21 7 2067 2073 10.1007/s00520‑013‑1765‑z 23435597
    [Google Scholar]
  47. Lee S. Jerng U.M. Liu Y. Kang J.W. Nam D. Lee J. The effectiveness and safety of moxibustion for treating cancer-related fatigue: A systematic review and meta-analyses. Support. Care Cancer 2014 22 5 1429 1440 10.1007/s00520‑014‑2161‑z 24609979
    [Google Scholar]
  48. Su C.X. Wang L.Q. Grant S.J. Liu J.P. Chinese herbal medicine for cancer-related fatigue: A systematic review of randomized clinical trials. Complement. Ther. Med. 2014 22 3 567 579 10.1016/j.ctim.2014.04.007 24906595
    [Google Scholar]
  49. Chute C.G. Greenberg E.R. Baron J. Korson R. Baker J. Yates J. Presenting conditions of 1539 population-based lung cancer patients by cell type and stage in new hampshire and vermont. Cancer 1985 56 8 2107 2111 10.1002/1097‑0142(19851015)56:8<2107::AID‑CNCR2820560837>3.0.CO;2‑T 2992757
    [Google Scholar]
  50. Walter FM Rubin G Bankhead C Morris HC Hall N Mills K Dobson C Rintoul RC Hamilton W Emery J Symptoms and other factors associated with time to diagnosis and stage of lung cancer: A prospective cohort study. Br J Cancer. 2015 112 1 6 13 10.1038/bjc.2015.30
    [Google Scholar]
  51. Hu P. Wang G. Cao H. Ma H. Sui P. Du J. Haemoptysis as a prognostic factor in lung adenocarcinoma after curative resection. Br. J. Cancer 2013 109 6 1609 1617 10.1038/bjc.2013.485 23963137
    [Google Scholar]
  52. Fidan A. Özdoğan S. Oruç Ö. Salepçi B. Öcal Z. Çağlayan B. Hemoptysis: A retrospective analysis of 108 cases. Respir. Med. 2002 96 9 677 680 10.1053/rmed.2002.1359 12243312
    [Google Scholar]
  53. Chung I.H. Park M. Kim D.H. Jeon G.S. Endobronchial stent insertion to manage hemoptysis caused by lung cancer. J. Korean Med. Sci. 2010 25 8 1253 1255 10.3346/jkms.2010.25.8.1253 20676346
    [Google Scholar]
  54. Aragon K.N. Palliative care in lung cancer. Clin. Chest Med. 2020 41 2 281 293 10.1016/j.ccm.2020.02.005 32402363
    [Google Scholar]
  55. Cordovilla R Bollo de Miguel E Nuñez Ares A Cosano Povedano FJ Herráez Ortega I Jiménez Merchán R Diagnosis and treatment of hemoptysis. Arch Bronconeumol. 2016 52 7 368 377 10.1016/j.arbr.2016.05.010
    [Google Scholar]
  56. Gottlieb L.S. Hillberg R. Endobronchial tamponade therapy for intractable hemoptysis. Chest 1975 67 4 482 483 10.1378/chest.67.4.482 1122780
    [Google Scholar]
  57. Conlan A.A. Hurwitz S.S. Management of massive haemoptysis with the rigid bronchoscope and cold saline lavage. Thorax 1980 35 12 901 904 10.1136/thx.35.12.901 7268664
    [Google Scholar]
  58. Garcia-Olivé I. Sanz-Santos J. Centeno C. Andreo F. Muñoz-Ferrer A. Serra P. Sampere J. Michavila J.M. Muchart J. Manzano J.R. Results of bronchial artery embolization for the treatment of hemoptysis caused by neoplasm. J. Vasc. Interv. Radiol. 2014 25 2 221 228 10.1016/j.jvir.2013.09.017 24252773
    [Google Scholar]
  59. Klein-Weigel P.F. Elitok S. Ruttloff A. Reinhold S. Nielitz J. Steindl J. Hillner B. Rehmenklau-Bremer L. Wrase C. Fuchs H. Herold T. Beyer L. Superior vena cava syndrome. Vasa 2020 49 6 437 448 10.1024/0301‑1526/a000908 33103626
    [Google Scholar]
  60. Rowell N.P. Gleeson F.V. Steroids, radiotherapy, chemotherapy and stents for superior vena caval obstruction in carcinoma of the bronchus: A systematic review. Clin. Oncol. (R. Coll. Radiol.) 2002 14 5 338 351 10.1053/clon.2002.0095 12555872
    [Google Scholar]
  61. Shah R.P. Bolaji O. Duhan S. Ariaga A.C. Keisham B. Paul T. Aljaroudi W. Alraies M.C. Superior Vena cava syndrome: An umbrella review. Cureus 2023 15 7 e42227 10.7759/cureus.42227 37605686
    [Google Scholar]
  62. Li Y. Yan B. He S. Advances and challenges in the treatment of lung cancer. Biomed. Pharmacother. 2023 169 115891 10.1016/j.biopha.2023.115891 37979378
    [Google Scholar]
  63. The Lancet Lung cancer treatment: 20 years of progress. Lancet 2024 403 10445 2663 10.1016/S0140‑6736(24)01299‑6 38908864
    [Google Scholar]
  64. Zelviene P. Kazlauskas E. Adjustment disorder: current perspectives. Neuropsychiatr. Dis. Treat. 2018 14 375 381 10.2147/NDT.S121072 29416339
    [Google Scholar]
  65. Satin J.R. Linden W. Phillips M.J. Depression as a predictor of disease progression and mortality in cancer patients. Cancer 2009 115 22 5349 5361 10.1002/cncr.24561 19753617
    [Google Scholar]
  66. Bruera E. Dev R. Overview of managing common non-pain symptoms in palliative care. https://www.uptodate.com/contents/overview-of-managing-common-non-pain-symptoms-in-palliative-care
  67. Van Beek F.E. Wijnhoven L.M.A. Custers J.A.E. Holtmaat K. De Rooij B.H. Horevoorts N.J.E. Aukema E.J. Verheul S. Eerenstein S.E.J. Strobbe L. Van Oort I.M. Vergeer M.R. Prins J.B. Verdonck-de Leeuw I.M. Jansen F. Adjustment disorder in cancer patients after treatment: Prevalence and acceptance of psychological treatment. Support. Care Cancer 2022 30 2 1797 1806 10.1007/s00520‑021‑06530‑0 34599663
    [Google Scholar]
  68. Mehta R.D. Roth A.J. Psychiatric considerations in the oncology setting. CA Cancer J. Clin. 2015 65 4 299 314 10.3322/caac.21285 26012508
    [Google Scholar]
  69. Stefan MS Knee AB Ready A Rastegar V Burgher Seaman J Gunn B Shaw E Bannuru RR Efficacy of models of palliative care delivered beyond the traditional physician-led, subspecialty consultation service model: A systematic review and meta-analysis. BMJ Support Palliat Care 2022 10.1136/bmjspcare‑2021‑003507
    [Google Scholar]
  70. Rowland S. Forbes R. Howell D. Kelly H. Haghayegh A. Cardinale M. Ramnanan T. Mayo S. Psychosocial and supportive care needs of individuals with advanced myeloma. Can. Oncol. Nurs. J. 2023 33 2 215 222 10.5737/23688076332215 37152822
    [Google Scholar]
  71. Okon T. Overview of comprehensive patient assessment in palliative care 2024 https://www.uptodate.com/contents/overview-of-comprehensive-patient-assessment-in-palliative-care
  72. Hidalgo L. Saldías-Fuentes C. Carrasco K. Halpern A.C. Mao J.J. Navarrete-Dechent C. Complementary and alternative therapies in skin cancer a literature review of biologically active compounds. Dermatol. Ther. 2022 35 11 e15842 10.1111/dth.15842 36124923
    [Google Scholar]
  73. Ernani V. Stinchcombe T.E. Management of brain metastases in non–small-cell lung cancer. J. Oncol. Pract. 2019 15 11 563 570 10.1200/JOP.19.00357 31715122
    [Google Scholar]
  74. Yamanaka R. Koga H. Yamamoto Y. Yamada S. Sano T. Fukushige T. Characteristics of patients with brain metastases from lung cancer in a palliative care center. Support. Care Cancer 2011 19 4 467 473 10.1007/s00520‑010‑0838‑5 20217148
    [Google Scholar]
  75. Bhattacharya P. Dessain S.K. Evans T.L. Palliative care in lung cancer: When to start. Curr. Oncol. Rep. 2018 20 11 90 10.1007/s11912‑018‑0731‑9 30414010
    [Google Scholar]
  76. Vogelbaum M.A. Brown P.D. Messersmith H. Brastianos P.K. Burri S. Cahill D. Dunn I.F. Gaspar L.E. Gatson N.T.N. Gondi V. Jordan J.T. Lassman A.B. Maues J. Mohile N. Redjal N. Stevens G. Sulman E. van den Bent M. Wallace H.J. Weinberg J.S. Zadeh G. Schiff D. Treatment for brain metastases: ASCO-SNO-ASTRO guideline. J. Clin. Oncol. 2022 40 5 492 516 10.1200/JCO.21.02314 34932393
    [Google Scholar]
  77. Owen S. Souhami L. The management of brain metastases in non-small cell lung cancer. Front. Oncol. 2014 4 248 10.3389/fonc.2014.00248 25309873
    [Google Scholar]
  78. Habberstad R. Hjermstad M.J. Brunelli C. Kaasa S. Bennett M.I. Pardon K. Klepstad P. Which factors can aid clinicians to identify a risk of pain during the following month in patients with bone metastases? A longitudinal analyses. Support. Care Cancer 2019 27 4 1335 1343 10.1007/s00520‑018‑4405‑9 30105665
    [Google Scholar]
  79. Razvi Y. Chan S. Zhang L. Tsao M. Barnes E. Danjoux C. Sousa P. Zaki P. McKenzie E. DeAngelis C. Chow E. A review of the rapid response radiotherapy program in patients with advanced cancer referred for palliative radiotherapy over two decades. Support. Care Cancer 2019 27 6 2131 2134 10.1007/s00520‑018‑4474‑9 30246224
    [Google Scholar]
  80. Zhen S.Q. Jin M. Chen Y.X. Li J.H. Wang H. Chen H.X. Ultrasound-guided paravertebral nerve block anesthesia on the stress response and hemodynamics among lung cancer patients. World J. Clin. Cases 2022 10 7 2174 2183 10.12998/wjcc.v10.i7.2174 35321160
    [Google Scholar]
  81. Dash A. Das T. Russ Knapp F.F. Targeted radionuclide therapy of painful bone metastases: Past developments, current status, recent advances and future directions. Curr. Med. Chem. 2020 27 19 3187 3249 10.2174/0929867326666190201142814 30714520
    [Google Scholar]
  82. Kim J.H. Shen C.Y. Au P.C.M. Baek Y.H. Cheung C.L. Chung W.P. Kleinman N.J. Lam T.C. Liao T.C. Lin T.C. Shin J.Y. Sing C.W. Wong I.C.K. Lai E.C.C. Bone-targeting agents in major solid tumour metastases: A multinational cohort study. BMJ Support. Palliat. Care 2023 13 e3 e1064 e1073 10.1136/bmjspcare‑2021‑003062 35177433
    [Google Scholar]
  83. Adams J. Rauw J. Weller S. Campbell K.L. Pollock P. Goulart J. Physical activity recommendations for cancer survivors living with bony metastases: Views of oncologic healthcare providers. J. Cancer Surviv. 2021 15 3 414 417 10.1007/s11764‑021‑00999‑8 33604871
    [Google Scholar]
  84. Bădilă A.E. Rădulescu D.M. Niculescu A.G. Grumezescu A.M. Rădulescu M. Rădulescu A.R. Recent advances in the treatment of bone metastases and primary bone tumors: An up-to-date review. Cancers 2021 13 16 4229 10.3390/cancers13164229 34439383
    [Google Scholar]
  85. Yan Z. MuRong Z. Huo B. Zhong H. Yi C. Liu M. Liu M. Acupuncture as a complementary therapy for cancer-induced bone pain: A systematic review and meta-analysis. Front. Pain Res 2022 3 925013 10.3389/fpain.2022.925013 35978992
    [Google Scholar]
  86. Yousefi M. Reihani H. Heydari M. Nasimi Doost Azgomi R. Hashempur M.H. Complementary and alternative medicine use among cancer patients in Iran: A systematic review. Prev. Med. Rep. 2024 39 102644 10.1016/j.pmedr.2024.102644 38384965
    [Google Scholar]
  87. Barton K.I. Hazenbiller O. Freeman G. Kashluba K. Ball M. Aboutaha A. Puloski S.K.T. Monument M.J. Communication in surgical decision-making while managing metastatic bone disease: Matching patient expectations with surgical goals. Support. Care Cancer 2021 29 2 1111 1119 10.1007/s00520‑020‑05595‑7 32607597
    [Google Scholar]
  88. Guinan E.M. Devenney K. Quinn C. Sheill G. Eochagáin C.M. Kennedy M.J. McDermott R. Balding L. Associations among physical activity, skeletal related events, and patient reported outcomes in patients with bone metastases. Semin. Oncol. Nurs. 2022 38 2 151274 10.1016/j.soncn.2022.151274 35437198
    [Google Scholar]
  89. Chabowski M. Polanski J. Jankowska-Polańska B. Rosińczuk J. Szymanska-Chabowska A. Quality of life of patients with lung cancer. OncoTargets Ther. 2016 9 1023 1028 10.2147/OTT.S100685 27013895
    [Google Scholar]
  90. Wang H. Yue H. Ren M. Feng D. Dyadic effects of family-functioning and resilience on quality of life in advanced lung cancer patients and caregivers: An actor-partner interdependence mediation model. Eur. J. Oncol. Nurs. 2021 52 101963 10.1016/j.ejon.2021.101963 34004522
    [Google Scholar]
  91. Wang M. Sun Y. Zhang M. Yu R. Fu J. Effects of high-quality nursing care on quality of life, survival, and recurrence in patients with advanced nonsmall cell lung cancer. Medicine (Baltimore) 2022 101 37 e30569 10.1097/MD.0000000000030569 36123938
    [Google Scholar]
  92. Prini-Guadalupe L. Pérez-Ríos M. Ruano-Ravina A. Abal Arca J. Barros-Dios J.M. Leisure time activities and lung cancer. Epidemiology 2012 23 2 352 353 10.1097/EDE.0b013e3182458992 22317817
    [Google Scholar]
  93. Yang J.J. Yu D. White E. Lee D.H. Blot W. Robien K. Sinha R. Park Y. Takata Y. Gao Y.T. Smith-Byrne K. Monninkhof E.M. Kaaks R. Langhammer A. Borch K.B. Al-Shaar L. Lan Q. Sørgjerd E.P. Zhang X. Zhu C. Chirlaque M.D. Severi G. Overvad K. Sacerdote C. Aune D. Johansson M. Smith-Warner S.A. Zheng W. Shu X.O. Prediagnosis leisure-time physical activity and lung cancer survival: A pooled analysis of 11 cohorts. JNCI Cancer Spectr. 2022 6 2 pkac009 10.1093/jncics/pkac009 35603841
    [Google Scholar]
  94. Li C. Yuan J. Huang X. Zhang S. Hong Y. Zhong J. Correlation between depression and intimacy in lung cancer patients and their family caregivers. BMC Palliat. Care 2022 21 1 99 10.1186/s12904‑022‑00992‑7 35659220
    [Google Scholar]
  95. Aubin M. Vézina L. Verreault R. Simard S. Hudon É. Desbiens J.F. Fillion L. Dumont S. Tourigny A. Daneault S. Distress experienced by lung cancer patients and their family caregivers in the first year of their cancer journey. Palliat. Support. Care 2022 20 1 15 21 10.1017/S1478951521000377 33899723
    [Google Scholar]
  96. Dow L.A. Matsuyama R.K. Ramakrishnan V. Kuhn L. Lamont E.B. Lyckholm L. Smith T.J. Paradoxes in advance care planning: The complex relationship of oncology patients, their physicians, and advance medical directives. J. Clin. Oncol. 2010 28 2 299 304 10.1200/JCO.2009.24.6397 19933909
    [Google Scholar]
  97. Barazzetti G. Borreani C. Miccinesi G. Toscani F. What best practice could be in Palliative Care: An analysis of statements on practice and ethics expressed by the main health organizations. BMC Palliat. Care 2010 9 1 1 10.1186/1472‑684X‑9‑1 20205778
    [Google Scholar]
  98. Scandrett K.G. Reitschuler-Cross E.B. Nelson L. Sanger J.A. Feigon M. Boyd E. Chang C.H. Paice J.A. Hauser J.M. Chamkin A. Balfour P. Stolbunov A. Bennett C.L. Emanuel L.L. Feasibility and effectiveness of the NEST13+ as a screening tool for advanced illness care needs. J. Palliat. Med. 2010 13 2 161 169 10.1089/jpm.2009.0170 19821699
    [Google Scholar]
  99. Ferrell B.R. Smith T.J. Levit L. Balogh E. Improving the quality of cancer care: Implications for palliative care. J. Palliat. Med. 2014 17 4 393 399 10.1089/jpm.2013.0536 24548217
    [Google Scholar]
  100. El-Jawahri A. Podgurski L.M. Eichler A.F. Plotkin S.R. Temel J.S. Mitchell S.L. Chang Y. Barry M.J. Volandes A.E. Use of video to facilitate end-of-life discussions with patients with cancer: A randomized controlled trial. J. Clin. Oncol. 2010 28 2 305 310 10.1200/JCO.2009.24.7502 19949010
    [Google Scholar]
  101. Avancini A. Sartori G. Gkountakos A. Casali M. Trestini I. Tregnago D. Bria E. Jones L.W. Milella M. Lanza M. Pilotto S. Physical Activity and exercise in lung cancer care: Will promises be fulfilled? Oncologist 2020 25 3 e555 e569 10.1634/theoncologist.2019‑0463 32162811
    [Google Scholar]
  102. Pyke-Grimm K.A. Fisher B. Haskamp A. Bell C.J. Newman A.R. Providing palliative and hospice care to children, adolescents and young adults with cancer. Semin. Oncol. Nurs. 2021 37 3 151166 10.1016/j.soncn.2021.151166 34175165
    [Google Scholar]
  103. Mathew A Doorenbos AZ Vincent C Symptom management theory: Analysis, evaluation, and implications for caring for adults with cancer. ANS Adv Nurs Sci 2021 44 3 93 112 10.1097/ANS.0000000000000347
    [Google Scholar]
  104. Finucane A. Carduff E. Meade R. Doyle S. Fenning S. Cumming S. Hekerem D. Rahman F. Lugton J. Johnston B. Murray S.A. Palliative care research promotion in policy and practice: A knowledge exchange process. BMJ Support. Palliat. Care 2022 12 e3 e285 e292 Epub ahead of print 10.1136/bmjspcare‑2021‑003096 34400402
    [Google Scholar]
  105. Almack K. Uncertain trajectories in old age and implications for families and for palliative and end of life care policy and practice. Death Stud. 2021 45 7 563 572 10.1080/07481187.2019.1671539 31578936
    [Google Scholar]
  106. Al Yacoub R. Rangel A.P. Shum-Jimenez A. Greenlee A. Yao Y. Schoppee T.M. Fitchett G. Handzo G. Chochinov H.M. Emanuel L.L. Kittelson S. Wilkie D.J. Cost considerations for implementing dignity therapy in palliative care: Insights and implications. Palliat. Support. Care 2023 1-5 1 5 Epub ahead of print 10.1017/S1478951523001177 37565429
    [Google Scholar]
  107. King J. Patel K. Woolf D. Hatton M.Q. The use of palliative radiotherapy in the treatment of lung cancer. Clin. Oncol. (R. Coll. Radiol.) 2022 34 11 761 770 10.1016/j.clon.2022.08.032 36115746
    [Google Scholar]
  108. Ingle P.V. Binti Samsudin S.Z. Pei Qi C. Mei Kei N. Li Xuan H. Siu Ching Y. Chai Siaw Hui A. Wong San Ying A. Development and novel therapeutics in hepatocellular carcinoma: A review. Ther. Clin. Risk Manag. 2016 12 445 455 10.2147/TCRM.S92377 27042086
    [Google Scholar]
  109. Korfage I.J. Carreras G. Arnfeldt Christensen C.M. Billekens P. Bramley L. Briggs L. Bulli F. Caswell G. Červ B. van Delden J.J.M. Deliens L. Dunleavy L. Eecloo K. Gorini G. Groenvold M. Hammes B. Ingravallo F. Jabbarian L.J. Kars M.C. Kodba-Čeh H. Lunder U. Miccinesi G. Mimić A. Ozbič P. Payne S.A. Polinder S. Pollock K. Preston N.J. Seymour J. Simonič A. Thit Johnsen A. Toccafondi A. Verkissen M.N. Wilcock A. Zwakman M. van der Heide A. Rietjens J.A.C. Advance care planning in patients with advanced cancer: A 6-country, cluster-randomised clinical trial. PLoS Med. 2020 17 11 e1003422 10.1371/journal.pmed.1003422 33186365
    [Google Scholar]
  110. Jadhav U. Bhanushali J. Sindhu A. Reddy B.S.K. Navigating compassion: A comprehensive review of palliative care in respiratory medicine. Cureus 2023 15 12 e50613 10.7759/cureus.50613 38226109
    [Google Scholar]
/content/journals/cctr/10.2174/0115733947346619241219100104
Loading
Current Developments in Palliative Care for Patients with Lung Cancer
Bentham Science Publishers ; https://doi.org/10.2174/0115733947346619241219100104
/content/journals/cctr/10.2174/0115733947346619241219100104
/content/journals/cctr/10.2174/0115733947346619241219100104
Loading

Data & Media loading...


  • Article Type:     Review Article
Keywords: prognosis ; lung cancer ; Education ; symptom management ; palliative care

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test