Current Cancer Drug Targets - Online First

The current review delves into the transformative role of precision medicine in addressing Colorectal Cancer [CRC], a pressing global health challenge. It examines closely signalling pathways, genetic and epigenetic modifications, and microsatellite instability. The primary focus is on elucidating biomarkers revolutionizing CRC diagnosis and treatment. Genetic biomarkers encompass non-coding RNA, epigenetic marker Read More

Background Lenvatinib is an oral tyrosine kinase inhibitor that selectively inhibits receptors involved in tumor angiogenesis and tumor growth. It is an emerging first-line treatment agent for hepatocellular carcinoma (HCC). However, there is no intravenous administration of Lenvatinib. Aims This study aimed to construct nanocomposites that can efficiently support Lenvatinib and target liver cancer tissues and cells. Objective Read More

Background Nasopharyngeal cancer [NPC] is prevalent in Southeast Asia and North Africa, and is generally associated with limited treatment options and poor patient prognosis. Objective Ferroptosis is a recently observed cell death modality and has been shown to link to the efficacy of different anti-cancer treatments, thus offering opportunities for the development of novel therapies. This study aims to investigate the p Read More

This review explores articles concerning the experimental research cycle on genome instability in cell populations of highly malignant recurrent organotropic rhabdomyosarcoma RA-2 in rats. Clonal analysis and cloning were pivotal components of this research, which relies on the frequency of cells with micronuclei and internuclear bridges to gauge the intensity of chromothripsis and break-fusion-bridge cycles. The efficacy o Read More

Background Gastrointestinal (GI) cancers represent some of the most common and lethal malignancies globally, underscoring the urgent need for improved diagnostic strategies. Traditional diagnostic methods, while effective to some degree, are often invasive and unsuitable for regular screenings. Objective This review article explores integrating machine learning (ML) with liquid biopsy techniques as a revolutionary app Read More

Cancer is one of the leading causes of mortality and morbidity worldwide. It is characterized by unmanaged cell proliferation and growth, leading to tumour formation with the potential to metastasize to various organs of the human body. Currently, several common therapeutic approaches exist to treat malignancies, including chemotherapy, surgery, and radiotherapy, which can be used to prevent the progression of malignancie Read More

Crucial for understanding liver cancer patients overall health outcomes. This research aimed to assess the CVM risk of them. Methods and Materials Data sourced from the Surveillance, Epidemiology, and End Results (SEER) database encompassing liver cancer diagnoses from 2000 to 2017 were utilized. The standardized mortality rate (SMR) was computed using general population reference data, and multivariate competing risk Read More

Introduction/Objective Lung cancer causes hundreds of thousands of deaths each year worldwide. FHOD3 was reported to accelerate the progression of brain cancer. However, its role in lung cancer is not clear. This study aimed to investigate the role of FHOD3 in lung cancer. Methods The clinical significance of FHOD3 in lung cancer was analyzed based on the data from the TCGA database. The expression level of FHO Read More

Background Neuroblastoma (NB) is a well-known pediatric malignancy intertwined with neurodevelopment. Previously implicated in neuronal differentiation, Zinc Finger Protein 536 (ZNF536) has emerged as a promising prognostic and immune-related biomarker in our pan-cancer analysis. Methods Single-cell RNA transcriptome sequencing, bulk transcriptome analysis, and immunohistochemistry were used to assess ZNF53 Read More