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image of Competing Risk Analysis for Diabetes Mellitus Mortality in Bladder Cancer Patients: A Population-based Study

Abstract

Background

Historically, there has been a lack of focus on the mortality rates of individuals with both diabetes and Bladder Bancer (BC). Our study aimed to identify the risk factors associated with death from Diabetes Mellitus (DM) in BC patients.

Methods

Data was gathered from the SEER database on individuals who were diagnosed with BC between the years 2000 and 2017. Calculation of the Standardized Mortality Ratio (SMR) was performed to determine the mortality rate of DM in patients from BC. Potential risk factors for DM mortality were identified by a multivariate competing risk model. Hazard Ratios (HR), with 95% confidence intervals (95% CI) were used to indicate the degree of associated risk.

Results

A total of 217,230 BC patients' data were collected from the SEER database for analysis. Among them, 98,880 patients passed away, and 1,783 patients encountered DM mortality. The overall SMR for DM mortality in BC patients was 3.32 (95% CI: 3.17-3.48). Results indicated that SMR increased with increasing years but decreased with increasing follow-up time. Multivariate competing risk analysis shows that BC patients with the following factors were at higher risk of developing DM mortality: advanced age, male, black, tumor stage, early year of diagnosis, pathology type of transitional cell carcinoma, without chemotherapy or radiation therapy, and absence of spouse (including separated, divorced, widowed, and unmarried).

Conclusion

Individuals diagnosed with BC are at a considerably elevated risk of mortality from DM compared to the general population. It is of the utmost importance to identify high-risk groups and implement effective interventions for DM in order to enhance the survival rate among this patient population.

© 2025 Bentham Science Publishers
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2025-03-06
2025-05-25

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References

  1. Sung H. Ferlay J. Siegel R.L. Laversanne M. Soerjomataram I. Jemal A. Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries CA. Cancer. J. Clin. 2021 71 3 209 249 10.3322/caac.21660 33538338
    [Google Scholar]
  2. Richters A. Aben K. Kiemeney L. The global burden of urinary bladder cancer: An update. World. J. Urol. 2020 38 8 1895 1904 10.1007/s00345‑019‑02984‑4 31676912
    [Google Scholar]
  3. Siegel R.L. Miller K.D. Fuchs H.E. Jemal A. Cancer statistics, 2021. CA. Cancer. J. Clin. 2021 71 1 7 33 10.3322/caac.21654 33433946
    [Google Scholar]
  4. Ali M.K. Pearson-Stuttard J. Selvin E. Gregg E.W. Interpreting global trends in type 2 diabetes complications and mortality. Diabetologia. 2022 65 1 3 13 34837505 10.1007/s00125‑021‑05585‑2
    [Google Scholar]
  5. Gallagher E.J. LeRoith D. Obesity and diabetes: The increased risk of cancer and cancer-related mortality. Physiol. Rev. 2015 95 3 727 748 10.1152/physrev.00030.2014 26084689
    [Google Scholar]
  6. Giovannucci E. Harlan D.M. Archer M.C. Bergenstal R.M. Gapstur S.M. Habel L.A. Pollak M. Regensteiner J.G. Yee D. Interpreting global trends in type 2 diabetes complications and mortality. CA. Cancer. J. Clin. 2010 60 4 207 221 20554718 10.3322/caac.20078
    [Google Scholar]
  7. Zaorsky NG Zhang Y Tuanquin L Bluethmann SM Park HS Chinchilli VM Suicide among cancer patients. Nat. Commun. 2022 10 1 207 10.1038/s41467‑018‑08170‑1 30643135
    [Google Scholar]
  8. Sturgeon KM Deng L Bluethmann SM Zhou S Trifiletti DM Jiang C Kelly S.P. Zaorsky N.G. A population-based study of cardiovascular disease mortality risk in US cancer patients. Eur. Heart. J. 2019 40 48 3889 3897 10.1093/eurheartj/ehz766 31761945
    [Google Scholar]
  9. Wojciechowska J. Krajewski W. Bolanowski M. Krecicki T. Zatonski T. Diabetes and cancer: A review of current knowledge. 2016 124 5 263 275 10.1055/s‑0042‑100910 27219686
    [Google Scholar]
  10. Peairs K.S. Barone B.B. Snyder C.F. Yeh H.C. Stein K.B. Derr R.L. Diabetes mellitus and breast cancer outcomes: A systematic review and meta-analysis. J. Clin. Oncol. 2022 29 1 40 46 10.1200/JCO.2009.27.3011 21115865
    [Google Scholar]
  11. Siegel R.L. Miller K.D. Wagle N.S. Jemal A. Cancer statistics, 2023. CA. Cancer. J. Clin. 2022 73 1 17 48 10.3322/caac.21763 36633525
    [Google Scholar]
  12. International Diabetes Federation IDF Diabetes Atlas 2019 Available from: https://www.diabetesatlas.org/en/
  13. Zhou B Lu Y Hajifathalian K Bentham J Di Cesare M Danaei G Worldwide trends in diabetes since 1980: A pooled analysis of 751 population-based studies with 4.4 million participants. NCD. Risk. Factor. Collaboration. (NCD-RisC). 2022 387 10027 1513 1530 10.1016/S0140‑6736(16)00618‑8 27061677
    [Google Scholar]
  14. Yu D. Zhao Z. Osuagwu U.L. Pickering K. Baker J. Cutfield R. Orr-Walker B.J. Cutfield R Cutfield R. Ethnic differences in mortality and hospital admission rates between Māori, Pacific, and European New Zealanders with type 2 diabetes between 1994 and 2018: A retrospective, population-based, longitudinal cohort study. Lancet. Glob. Health. 2021 9 2 e209 e217 10.1016/S2214‑109X(20)30412‑5 33069275
    [Google Scholar]
  15. Zhu X. Heng Y. Zhou L. Zhang M. Cao P. Tao L. Diabetic mortality risk among cancer patients in the United State SEER population, 1975-2016. Endocrine. 2020 70 2 323 330 10.1007/s00125‑021‑05585‑2 32643048
    [Google Scholar]
  16. Clements J.M. West B.T. Yaker Z. Lauinger B. McCullers D. Haubert J. Disparities in diabetes-related multiple chronic conditions and mortality: The influence of race. Diabetes. Res. Clin. Pract. 2020 10.1016/j.diabres.2019.107984 31846667
    [Google Scholar]
  17. Wang Y O'Neil A Jiao Y Wang L Huang J Lan Y Sex differences in the association between diabetes and risk of cardiovascular disease, cancer, and all-cause and cause-specific mortality: A systematic review and meta-analysis of 5,162,654 participants. BMC. Med. 2019 17 1 136 10.1186/s12916‑019‑1355‑0 31296205
    [Google Scholar]
  18. Aizer A.A. Chen M.H. McCarthy E.P. Mendu M.L. Koo S. Wilhite T.J. Marital status and survival in patients with cancer. J. Clin. Oncol. 2013 31 31 3869 76 10.1200/JCO.2013.49.6489 24062405
    [Google Scholar]
  19. Gallo LC Troxel WM Matthews KA Kuller LH Marital status and quality in middle-aged women: Associations with levels and trajectories of cardiovascular risk factors. Health. Psychol. 2003 22 5 453 63 10.1037/0278‑6133.22.5.453 14570528
    [Google Scholar]
  20. Lu H. Zhu W. Mao W. Zu F. Wang Y. Li W. Trends of incidence and prognosis of primary adenocarcinoma of the bladder. Ther. Adv. Urol. 2021 13 17562872211018006 10.1177/17562872211018006 34104222
    [Google Scholar]
/content/journals/ccdt/10.2174/0115680096356675250217074915
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Competing Risk Analysis for Diabetes Mellitus Mortality in Bladder Cancer Patients: A Population-based Study
Bentham Science Publishers ; https://doi.org/10.2174/0115680096356675250217074915
/content/journals/ccdt/10.2174/0115680096356675250217074915
/content/journals/ccdt/10.2174/0115680096356675250217074915
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  • Article Type:     Research Article
Keywords: diabetes mortality ; SEER ; Bladder cancer ; competing risk regression

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