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Volume 4, Issue 2
  • ISSN: 2452-2716
  • E-ISSN: 2452-2724

Abstract

Polysarcosine (psar) is a non-ionic hydrophilic polypeptoid with numerous biologically relevant properties. Polysarcosine is poly (n-methylated glycine) and has been reported first by Weslay and co-workers in the 1920s. Polysarcosine was first synthesized ring-opening polymerization (rop) of sarcosine -carboxyanhydride, using high-vacuum techniques. Overall, findings highlight the potential of poly(sarcosine) as an alternative corona-forming polymer to poly (ethylene glycol)-based analogues of (polymerization-induced self- pisa assemblies for use in various pharmaceutical and biomedical applications. Numerous studies suggested that such polypeptoids hold enormous potential for many biomedical applications, including protein delivery, colloidal stabilization, and nanomedicine.

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2021-08-01
2025-01-10

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/content/journals/caps/10.2174/2452271604999201124222313
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Polysarcosine: The Best Alternative of Poly (Ethylene Glycol)
Curr Appl Polym Sci 4, 93 (2021); https://doi.org/10.2174/2452271604999201124222313
/content/journals/caps/10.2174/2452271604999201124222313
/content/journals/caps/10.2174/2452271604999201124222313
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  • Article Type:     Review Article
Keyword(s): biomedical applications poly (Ethylene Glycol); N-methylated glycine; nanomedicine; PEGylation; polypeptoid; Polysarcosine

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