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Volume 6, Issue 2
  • ISSN: 2452-2716
  • E-ISSN: 2452-2724

Abstract

Porous microsponges are a type of polymeric delivery method. These tiny, spherical particles, resembling sponges, have a large porous surface, which helps to modify drug release, stabilize the substance, and lessen side effects. To keep dose forms on the skin, micro sponges can be successfully included intopical medicine administration systems. Since the outer surface is frequently porous, the material can continuously flow out of the sphere. This system can suspend or entrap a variety of substances, and it can be incorporated into a manufactured product like a liquid, gel, cream, or powder. The majority of vehicles and components can be used with these formulations, which are stable in the pH range of 1 to 11 and up to 130ºC. Microsponges are created to reduce side effects, change medication release, and enhance stability to successfully distribute a pharmaceutically active component at the lowest amount achievable.

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2025-06-22

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References

  1. SinghviG. ManchandaP. HansN. DubeyS.K. GuptaG. Microsponge: An emerging drug delivery strategy.Drug Dev. Res.201980220020810.1002/ddr.2149230456763
     [Google Scholar]
  2. VitthalP. AnuradhaS. A review on microsponges drug delivery system.IJRAR202071961974Available from: https://ssrn.com/abstract=3677770
    [Google Scholar]
  3. PradhanS.K. MDS as the versatile tool for drug delivery system.Int. J. Res. Pharm. Chem.201112243258Available from: https://www.ijrpc.com/
    [Google Scholar]
  4. ShahC.N. ShahD.P. Microsponges: A revolutionary path breaking modified drug delivery of topical drug.Int J Pharmaceut Res201462113
     [Google Scholar]
  5. SharmaS. KaurM. KaurS. Microsponge technology as a novel approach for topical drug delivery: An acquainted review.IOSR J. Pharm. Biol. Sci.202015511310.9790/3008‑1505030113
     [Google Scholar]
  6. PatelA. UpadhyayP. TrivediJ. ShahS. PatelJ. Microsponges as the versatile tool for topical route: A review.Int. J. Pharm. Sci. Res.2012392926293710.13040/IJPSR.0975‑8232.3(9).2926‑37
     [Google Scholar]
  7. VishwakarmaP. ChoudharyR. Dec15:Microsponges: A novel strategy to control the delivery rate of active agents with reduced skin irritancy.J. Drug Deliv. Ther.201996-s23824710.22270/jddt.v9i6‑s.3757
     [Google Scholar]
  8. AmrutiyaN. BajajA. MadanM. Development of microsponges for topical delivery of mupirocin.AAPS PharmSciTech200910240240910.1208/s12249‑009‑9220‑719381834
     [Google Scholar]
  9. KaityS. MaitiS. GhoshA. PalD. GhoshA. BanerjeeS. Microsponges: A novel strategy for drug delivery system.J. Adv. Pharm. Technol. Res.20101328329010.4103/0110‑5558.7241622247859
     [Google Scholar]
  10. PatilR.S. Microsponge drug delivery system: A novel dosage form.Am J PharmTech Res201224227251
     [Google Scholar]
  11. KumarS. TyagiL.K. SinghD. Microsponge delivery system (MDS): A unique technology for delivery of active ingredients.Int. J. Pharm. Sci. Res.20112123069308010.13040/IJPSR.0975‑8232.2(12).3069‑80
     [Google Scholar]
  12. BalamuruganK. KshirasagarG.P. Microsponge: As a drug delivery system.J. Pharm. Innov.201981139143
     [Google Scholar]
  13. WonR. Method for delivering an active ingredient by controlled time release utilizing a novel delivery vehicle which can be prepared by a process utilizing the active ingredients as a Porogen.US. Patent 4690825,1987
     [Google Scholar]
  14. MandavaS.S. ThavvaV. Novel approach: Microsponge drug delivery system.IJPSR20123496798010.13040/IJPSR.0975‑8232.3(4).967‑80
     [Google Scholar]
  15. NidhiK. VermaS. KumarS. Microsponge: An advanced drug delivery system.J. Clin. Sci. Res.202110210811110.4103/JCSR.JCSR_42_19
     [Google Scholar]
  16. PatidarK. SoniM. SaxenaC. SoniP. SharmaD.K. Micro sponges versatile vesicular approach for transdermal drug delivery system.J. Glob. Pharma Technol.201023154164
     [Google Scholar]
  17. D’SouzaJ.I. MoreH.N. Topical anti-inflammatory gels of fluocinolone acetonide entrapped in eudragit based microsponge delivery system.Res J Pharm Technol200814502506
     [Google Scholar]
  18. TileM.K. PawarA.Y. Microsponges: A novel strategy for drug delivery.Int J Pure App Biosci201531224235Available from: http://www.ijpab.com/
    [Google Scholar]
  19. PatelS.B. PatelH.J. SethA.K. Microsponge drug delivery system: An overview.J. Glob. Pharma Technol.20102819
     [Google Scholar]
  20. SalunkheP. Formulation and evaluation of microsponge gel for topical delivery of antifungal drug.Int J Appl Pharm.20179430710.22159/ijap.2017v9i4.17760
     [Google Scholar]
  21. AloorkarN. KulkarniA.S. IngaleD.J. PatilR.A. Microsponges as innovative drug delivery systems.Int J Pharm Sci Nanotechnol2012511597160610.37285/ijpsn.2012.5.1.2
     [Google Scholar]
  22. AloorkarN.H. A new cornucopia in topical drug delivery microsponge technology.Asian J Pharm Sci Technol2014414860
     [Google Scholar]
  23. TiwariA. MishraM.K. ShuklaA. YadavS.K. Microsponge: Anaugmented drug delivery system.Am J PharmTech Res2016667995
     [Google Scholar]
  24. KarA.K. KarB. ParyaH. KunduS. HirawatR. A novel approach on microsponge: Multifunctional modern dosage form.Int. J. Pharm. Sci. Rev. Res.20185126472Available from: https://globalresearchonline.net/journalcontents/v51-2/12.pdf
    [Google Scholar]
  25. RajeswariS. SwapnaV. Microsponges as a neoteric cornucopia for drug delivery systems.Int. J. Curr. Pharm. Res.201911341210.22159/ijcpr.2019v11i3.34099
     [Google Scholar]
  26. KapporD. PatelM. VyasR.B. LadC. TyagiB.L. A review on microsponge drug delivery system.J. Drug Deliv. Ther.201445293510.22270/jddt.v4i5.978
     [Google Scholar]
  27. FarooqU. MalviyaR. SharmaP. Advancement in microsphere preparation using natural polymers and recent patents.Recent Pat. Drug Deliv. Formul.20148211112510.2174/187221130866614021811052024597612
     [Google Scholar]
  28. KhopadeA. JainS. JainN. The microsponge.Eastern Pharmacist1996394594953
     [Google Scholar]
  29. SrivastavaR. PathakK. Microsponges: A futuristic approach for oral drug delivery.Expert Opin. Drug Deliv.20129786387810.1517/17425247.2012.69307222663167
     [Google Scholar]
  30. ThomasT.P. Microsponge drug delivery system for topical delivery - A review.IJPCBS201664424431Available from: https://www.ijpcbs.com/articles/microsponge-drug-delivery-ststemfor-topicaldeliverya-review.pdf
    [Google Scholar]
  31. DubeyD. MalviyaR. SharmaP. Advancement in microsponge drug delivery system: preparation methods, patents and commercial utility.Recent Pat. Drug Deliv. Formul.20148210111010.2174/187221130866614030522290524548242
     [Google Scholar]
  32. ChardeM.S. GhanawatP.B. WelankiwarA.S. KumarJ. ChakoleR.D. MicrospongeA. Novel New Drug Delivery System: A Review.Int J Adv Pharm20132618Available from: https://core.ac.uk/download/pdf/335077979.pdf
    [Google Scholar]
  33. NandaS. Microsponge drug delivery system: An overview.World J. Pharm. Pharm. Sci.20132310321043
     [Google Scholar]
  34. AldawsariH. Microsponges as promising vehicle for drug delivery and targeting: Preparation, characterization and applications.Afr. J. Pharm. Pharmacol.201371787388110.5897/AJPP12.1329
     [Google Scholar]
  35. Propranolol hydrochloride.1967Available from: https://go.drugbank.com/salts/DBSALT000549
  36. WEBMD Spotlight Available from: https://www.webmd.com/search/search_results/default.aspx?query=XANTHAN%20GUM
  37. RawatS.P. DhyaniA. SinghV. JuyalD. Brief review of microsponges: An update.Pharma Innov J201765134139Available from: https://www.thepharmajournal.com/archives/?year=2017&vol=6&issue=5&ArticleId=1059
    [Google Scholar]
  38. RaviR. SenthilkumarS.K. ParthibanS. Microsponges drug delivery system: A review.Int J Pharm Rev Res20133611
     [Google Scholar]
  39. EmanueleA.D. Preparation, characterisation, and drug release from thermoresponsive microspheres.Int. J. Pharm.1995118223724210.5897/AJPP12.1329
     [Google Scholar]
  40. ChadawarV. ShajiJ. Microsponge delivery system.Curr. Drug Deliv.20074212312910.2174/15672010778036232017456031
     [Google Scholar]
  41. MuthukumarS. SrideviM. SankarC. ArulkumaranK.S.G. Microsponge Delivery System. Research and Development in Pharmaceutical Science.2021Volume II8393Available from: https://www.bhumipublishing.com/wp-content/uploads/2021/07/Research-and-Development-in-Pharmaceutical-Science-Volume-II.pdf
    [Google Scholar]
  42. ÇomoğluT GönülN BaykaraT Preparation and in vitro evaluation of modified release ketoprofen microsponges.Farmaco200358210110610.1016/S0014‑827X(02)00007‑112581775
     [Google Scholar]
  43. PandayP. ShuklaN. SisodiyaD. JainV. MahajanS. Design and characterization of microsponge loaded controlled release epicutaneous gel of lornoxicam.Appl Med Res201511162110.5455/amr.20150127052147
     [Google Scholar]
  44. RekhaU. ManjulaB.P. Formulation and evaluation of microsponges for topical drug delivery of Mometasone furoate.Int. J. Pharm. Pharm. Sci.201134133137Available from: https://innovareacademics.in/journal/ijpps/Vol3Issue4/2534.pdf
    [Google Scholar]
  45. GadeR. MakineniA. AparnaA. Design and development of hydroxyzine hydrochloride controlled release tablets based on microsponge technology.Carib J SciTech20131172184Available from: https://caribjscitech.com/index.php/cjst/article/view/93
    [Google Scholar]
  46. KadnorN.A. PandeV.V. KadamR. UpadhyeS.A. Fabrication and characterization of sertaconazole nitrate microsponge as a topical drug delivery system.Indian J. Pharm. Sci.201577667568010.4103/0250‑474X.17498626997694
     [Google Scholar]
  47. OrrC.Jr Application of mercury penetration to materials analysis.Powder Technol.19693111712310.1016/0032‑5910(69)80064‑1
     [Google Scholar]
  48. OrluM. CevherE. AramanA. Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges.Int. J. Pharm.20063181-210311710.1016/j.ijpharm.2006.03.02516687222
     [Google Scholar]
  49. KumarS. Microsponge delivery system (MDS): A unique technology for delivery of active ingredients.IJPSR201121230693080Available from: https://ijpsr.com/bft-article/microsponge-deliverysystem-mds-a-unique-technology-for-delivery-of-activeingredients/
    [Google Scholar]
  50. KhattabA. NattoufA. Microsponge based gel as a simple and valuable strategy for formulating and releasing Tazarotene in a controlled manner.Sci. Rep.20221211141410.1038/s41598‑022‑15655‑z35794139
     [Google Scholar]
  51. HeY. MajidK. MaqboolM. Formulation and characterization of lornoxicam-loaded cellulosic-microsponge gel for possible applications in arthritis.Saudi Pharm. J.2020288994100310.1016/j.jsps.2020.06.02132792844
     [Google Scholar]
  52. DarekarA. PawarP. SaudagarR.B. A review on microsponge as emerging drug delivery system.J. Drug Deliv. Ther.201993-s79380110.22270/jddt.v9i3‑s.2828
     [Google Scholar]
  53. TiwariA. TiwariV. PalariaB. KumarM. KaushikD. Microsponges: A breakthrough tool in pharmaceutical research.Future J Pharm Sci2022813110.1186/s43094‑022‑00421‑9
     [Google Scholar]
  54. D’souzaJ.I. HarinathN.M. The microsponge drug delivery system: For delivering an active ingredient by controlled time release.Pharma Info Net20086363Available from: https://www.researchgate.net/publication/26575578_The_Microsponge_Drug_Delivery_System_For_Delivering_an_Active_Ingredient_by_Controlled_Time_Release
    [Google Scholar]
  55. DuttaD. GoyalN. SharmaD.K. Preclinical evaluation from in silico to in vivo study of polyherbal microsponge sunscreen gel.J. Cosmet. Dermatol.20222183578358510.1111/jocd.1467434962064
     [Google Scholar]
  56. JyotiJ. KumarS. Innovative and novel strategy: Microsponges for topical drug delivery.J. Drug Deliv. Ther.201885283410.22270/jddt.v8i5.1885
     [Google Scholar]
  57. TripathiP.K. GorainB. ChoudhuryH. SrivastavaA. KesharwaniP. Dendrimer entrapped microsponge gel of dithranol for effective topical treatment.Heliyon201953e0134310.1016/j.heliyon.2019.e0134330957038
     [Google Scholar]
  58. JafarM. MohsinA.A. KhalidM.S. AlshahraniA.M. AlkhateebF.S. AlqarniA.S. Ranitidine hydrochloride stomach specific bouyant microsponge: Preparation, in-vitro characterization, and in-vivo anti-ulcer activity.J. Drug Deliv. Sci. Technol.20205510145310.1016/j.jddst.2019.101453
     [Google Scholar]
  59. DeviN. KumarS. PrasadM. RaoR. Eudragit RS100 based microsponges for dermal delivery of clobetasol propionate in psoriasis management.J. Drug Deliv. Sci. Technol.20205510134710.1016/j.jddst.2019.101347
     [Google Scholar]
  60. PatelC.N. Microsponge as topical drug delivery system.J. Glob. Pharma Technol.201021729
     [Google Scholar]
  61. ObiedallahM.M. Abdel-MageedA.M. ElfahamT.H. Ocular administration of acetazolamide microsponges in situ gel formulations.Saudi Pharm. J.201826790992010.1016/j.jsps.2018.01.00530416345
     [Google Scholar]
  62. KumarP.M. GhoshA. Development and evaluation of silver sulfadiazine loaded microsponge based gel for partial thickness (second degree) burn wounds.Eur. J. Pharm. Sci.20179624325410.1016/j.ejps.2016.09.03827697504
     [Google Scholar]
  63. Mahesh KumarP. GhoshA. Development and evaluation of metronidazole loaded microsponge based gel for superficial surgical wound infections.J. Drug Deliv. Sci. Technol.201530152910.1016/j.jddst.2015.09.006
     [Google Scholar]
  64. AryaP. PathakK. Assessing the viability of microsponges as gastro retentive drug delivery system of curcumin: Optimization and pharmacokinetics.Int. J. Pharm.20144601-211210.1016/j.ijpharm.2013.10.04524184218
     [Google Scholar]
  65. MohanS. Formulation of fluconazole as topical antifungal gels by microsponge-based delivery systems.Indones. J. Pharm.201728410.14499/indonesianjpharm28iss3pp158
     [Google Scholar]
  66. OsmaniR.A.M. AloorkarN.H. IngaleD.J. Microsponges based novel drug delivery system for augmented arthritis therapy.Saudi Pharm. J.201523556257210.1016/j.jsps.2015.02.02026594124
     [Google Scholar]
  67. RajeshreeM. HarshaP. VishnuP. Microsponge for topical drug delivery system.Int J Pharm Technol20145428392851
     [Google Scholar]
  68. SahaT. Microsponge Drug Delivery System.2017Available from: https://www.researchgate.net/publication/321293435_Microsponge_Drug_Delivery_System
    [Google Scholar]
  69. D’SouzaJ.I. MoreH.N. Topical antiinflammatory gels of fluocinolone acetonide entrapped in eudragit-based microsponge delivery system.Res J Pharm Tech200814502506Available from: https://rjptonline.org/HTML_Papers/Research%20Journal%20of%20Pharmacy%20and%20Technology__PID__2008-1-4-101.html
    [Google Scholar]
  70. BihareeA. BhartiyaS. YadavA. TharejaS. JainA.K. Microsponges as drug delivery system: Past, present, and future perspectives.Curr. Pharm. Des.202329131026104510.2174/138161282966623040408274337013425
     [Google Scholar]
  71. Naga JyothiK. Dinesh KumarP. ArshadP. KarthikM. PanneerselvamT. Microsponges: A promising novel drug delivery system.J. Drug Deliv. Ther.201995-s18819410.22270/jddt.v9i5‑s.3649
     [Google Scholar]
  72. MohiteP.B. KhanageS.G. HarishchandreV.S. ShirshathY. Recent advances in microsponges drug delivery system.J Crit Rev201631916Available from: https://www.jcreview.com/admin/Uploads/Files/61c719137e7417.08748294.pdf
    [Google Scholar]
  73. KhanM. AkhtarN. SharmaV. PathakK. Product development studies on sonocrystallized curcumin for the treatment of gastric cancer.Pharmaceutics201572436310.3390/pharmaceutics702004325923809
     [Google Scholar]
  74. SonaliR. Formulation and evaluation of prednisolone loaded microsponges for colon targeted drug delivery: In-vitro and pharmacokinetic study.Int. J. Pharm. Sci. Res.2014551994200510.13040/IJPSR.0975‑8232.5(5).1994‑05
     [Google Scholar]
  75. AibibuD. HildM. WöltjeM. CherifC. Textile cell-free scaffolds for in situ tissue engineering applications.J. Mater. Sci. Mater. Med.20162736310.1007/s10856‑015‑5656‑326800694
     [Google Scholar]
  76. SumbriaR. GuptaN.B. BhandariN. KumarA. MahajanS. Microsponges: Topical preparation and its applications.World J. Pharm. Pharm. Sci.20176462964210.20959/wjpps20174‑8923
     [Google Scholar]
  77. ShyamS.M. VedavathiT. Novel approach: Microsponge drug delivery system.Int. J. Pharm. Sci. Res.201234967980Available from: https://ijpsr.com/bft-article/novel-approach-microspongedrug-delivery-system/
    [Google Scholar]
  78. GhadgeM. PurakasythyaD. PramanikA. GargS.K. Microsponge - aeon in the field of topical formulation.Int. J. Pharm. Pharm. Sci.20181413954Available from: https://ijppr.humanjournals.com/wp-content/uploads/2019/01/5.Madhvi-Ghadge-Dipayan-Purakasythya-Anup-Pramanik-Shiv-K.-Garg.pdf
    [Google Scholar]
  79. JagtapS.C. KaraleA.A. AmbekarA.W. Microsponge: A novel topical drug delivery system.J. Drug Deliv.20143419
     [Google Scholar]
  80. TejashriG. AmritaB. DarshanaJ. Cyclodextrin based nanosponges for pharmaceutical use: A review.Acta Pharm.201363333535810.2478/acph‑2013‑002124152895
     [Google Scholar]
  81. SarojK. Microsponges as the versatile tool for drug delivery system.IJRPC201112243258Available from: https://www.researchgate.net/publication/235945631_Microsponges_as_the_versatile_tool_for_drug_delivery_system
    [Google Scholar]
  82. GarudS.T. TiwariK. Microsponges: A novel approach.Asian J Pharm Sci Tech20188119
     [Google Scholar]
  83. ShahaV. Microsponges drug delivery: A review.IJRPS20101212218
     [Google Scholar]
  84. KaurL.P. Topical Gel: A Recent Approach for Novel Drug delivery.Asian J of Biomed and Pharm Sci201331715Available from: https://www.alliedacademies.org/articles/topical-gel-a-recent-approach-for-novel-drug-delivery.pdf
    [Google Scholar]
  85. NachtS. KantzM. The microsponge: A novel topical programmable delivery system.Top Drug Deliv Syst199242299325
     [Google Scholar]
  86. TannerT. MarksR. Delivering drugs by the transdermal route: review and comment.Skin Res. Technol.200814324926010.1111/j.1600‑0846.2008.00316.x19159369
     [Google Scholar]
  87. DumbreK. Microsponges: A novel drug delivery system.Asian J Pharmaceut Res Develop2014226574Available from: https://www.ajprd.com/index.php/journal/article/view/173
    [Google Scholar]
  88. IwaiS. SawaY. IchikawaH. Biodegradable polymer with collagen microsponge serves as a new bioengineered cardiovascular prosthesis.J. Thorac. Cardiovasc. Surg.2004128347247910.1016/j.jtcvs.2004.04.01315354111
     [Google Scholar]
  89. SagavkarS.R. Innovative and novel strategy: Microsponges drug delivery system.Pharma Biosci Int J Univ Pharma Biosci2014226574
     [Google Scholar]
  90. BorawakeP.D. KauslyaA. ShindeJ.V. ChavanR.S. Microsponge as an emerging technique in novel drug delivery system.J. Drug Deliv. Ther.202111117118210.22270/jddt.v11i1.4492
     [Google Scholar]
  91. KydonieusA.F. BernerB. Transdermal Delivery of Drugs.Boca RatonCRC Press1987
     [Google Scholar]
  92. AhmedA. MakramM. SayedM. LouisD. An overview of microsponge as a novel tool in drug delivery.MADD2018231710.31031/MADD.2018.02.000537
     [Google Scholar]
  93. ValluruR. RaviG. BoseS.P. DamineniS. Microsponges- a comprehensive review: Success and challenges.Indo Am J Pharm Res2019973056306710.5281/zenodo.3356512
     [Google Scholar]
  94. VermaR. KaushikD. Design and optimization of candesartan loaded self-nanoemulsifying drug delivery system for improving its dissolution rate and pharmacodynamic potential.Drug Deliv.202027175677110.1080/10717544.2020.176096132397771
     [Google Scholar]
  95. VermaR. KaushikA. AlmeerR. RahmanM.H. Abdel-DaimM.M. KaushikD. Improved pharmacodynamic potential of rosuvastatin by self-nanoemulsifying drug delivery system: An in vitro and in vivo evaluation.Int. J. Nanomedicine20211690592410.2147/IJN.S28766533603359
     [Google Scholar]
/content/journals/caps/10.2174/0124522716275567240226073505
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Microsponge: An Advanced Drug Delivery System
Curr Appl Polym Sci 6, 76 (2023); https://doi.org/10.2174/0124522716275567240226073505
/content/journals/caps/10.2174/0124522716275567240226073505
/content/journals/caps/10.2174/0124522716275567240226073505
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  • Article Type:     Review Article
Keyword(s): controlled release; liquid-liquid suspension polymerization; Microsponges topical drug delivery; porous; quasi emulsion solvent diffusion

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