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THERAPEUTIC REVOLUTION The History of Medical Oncology from Early Days to the Creation of the Subspecialty
Cancer is a disease responsible for several million annual deaths among humans worldwide. However advances in healthcare - which include breakthroughs in science and medicine as well as access to medical treatment - have improved the survival rate of cancer patients over the last few decades.
Therapeutic Revolution relates the story of one of the great scientific tales of the twentieth century: how the field of medical oncology was created and its subsequent development owing to medical and scientific breakthroughs. The book unfolds the pre-clinical and clinical concepts and innovations that led to the creation of the medical subspecialty now known as oncology.
Therapeutic Revolution is the first book ever written on the events that led to this subspecialty of internal medicine. It relates the recollection of key events obtained from interviews of the pioneers who laid the foundations of medical oncology as well as the authors own experience of the pre-specialty era of medical practice.
The eBook is essential reading for all readers interested in the history of cancer treatment and also serves as a historical primer for medical students learning oncology.
Technology Enterprise Business Models: A Handbook For The Post Pandemic Era
In the wake of the transformative global events since 2020 the economic landscape has undergone profound changes. Adapting to the new paradigms brought about by the pandemic requires innovative business models that seamlessly blend technology and offer hybrid online-offline services. This handbook is an essential guide for students and entrepreneurs navigating this evolving landscape. It equips readers with the knowledge and tools to create value and design effective online-offline business models that cater to the demands of the post-pandemic era.
Key Themes:
Technology-Service Management: Explore the concept of servitization relevant frameworks and the latest servitization trends that are reshaping industries.
Business Innovations: Learn how businesses have leveraged technology and service-oriented approaches to thrive during and after the pandemic.
Customer-Centric Models: Discover how to create business models that prioritize customer needs and preferences effectively bridging the online and offline realms.
Value Innovation: Explore how the convergence of technology and services drives value creation and contributes to social welfare.
Real-World Examples: Gain insights from exemplary cases of servitization illustrating how businesses have successfully overcome crisis situations. In an era defined by rapid change and uncertainty this book empowers readers to harness the potential of technology-driven service models. Whether you're a student seeking to understand these shifts or an entrepreneur looking to adapt and innovate this resource provides invaluable insights and practical guidance for the post-pandemic business landscape.
Technology for a Sustainable Environment
Environmental issues such as overexploitation pollution and degradation of natural resources have prompted us to look for ways to devise sustainable practices across industrial and public service sectors. Researchers and scientists all over the world are involved in developing strategies and techniques that help us achieve a sustainable environment. Technology for a Sustainable Environment presents an overview of various methods and techniques that can be adapted to sustain the environment. Chapters focus on techniques such as bioremediation nanotechnology and biotechnology that can play a very important role in achieving environmental sustainability goals. The chapters also provide a detailed account about use of biotechnology nanotechnology and other techniques in achieving environmental sustainability. Additionally the book includes a discussion about emerging technologies that promote environmental sustainability like green technologies biodegradable polymers and plastics. Readers will be able to understand how modern technologies can help in monitoring environmental pollutants remediation of environmental pollution and prevention of environmental degradation.
The book is suitable for readers professionals and scholars at all levels who require an understanding of the technology in environmental science environmental engineering and environmental biotechnology.
Terpenes
Medicinal chemists around the world have been inspired by nature and have successfully extracted chemicals from plants. Research on enzymatic modifications of naturally occurring compounds has played a critical role in the search for biologically active molecules to treat diseases.
This book set explores compounds of interest to researchers and clinicians. It presents a comprehensive analysis about the medicinal chemistry (drug design structure-activity relationships permeability data cytotoxicity appropriate statistical procedures molecular modelling studies) of different compounds. Each chapter brings contributions from known scientists explaining experimental results which can be translated into clinical practice.
Volume 2 gives (1) a detailed overview of the sesquiterpenes polypharmacology (2) an interesting journey around the world of cannabinoids that reveals the development of new synthetic & derivatives (3) the design of specific formulations to overcome the volatility of small sized terpenes-based essential oils (4) an update on the latest generations of endoperoxides endowed with antimalarial activity and finally (5) a summary of MedChem strategies to fix the most common issues in formulating terpene derivatives (like low potency and poor solubility).
The objective of this book set is to fulfill gaps in currently acquired knowledge with information from the recent years. It serves as a guide for academic and professional researchers and clinicians.
Terrestrial and Extraterrestrial Space Dangers: Outer Space Perils, Rocket Risks and the Health Consequences of the Space Environment
Natural elements and cosmic phenomena in space such as asteroids comets meteors black holes and super bubbles pose a threat to the planet Earth and spacefarers in the near-Earth environment. Terrestrial and Extraterrestrial Space Dangers describes these dangers in the near-Earth outer space environment. The uniquely risky nature of rocket transportation is documented and quantified. The human health consequences for vision muscles and the neurovestibular system for instance on exposure to an outer space environment are also explained in this book. Readers will benefit from the extensive information offered within this text which is also accompanied with a bibliography of references. This book offers a comprehensive primer for anyone interested in space travel and associated risk assessment.
Text Analysis with Python: A Research-Oriented Guide
Text Analysis with Python: A Research-Oriented Guide is a quick and comprehensive reference on text mining using python code. The main objective of the book is to equip the reader with the knowledge to apply various machine learning and deep learning techniques to text data. The book is organized into eight chapters which present the topic in a structured and progressive way.
Key Features:
Introduces the reader to Python programming and data processing
Introduces the reader to the preliminaries of natural language processing (NLP)
Covers data analysis and visualization using predefined python libraries and datasets
Teaches how to write text mining programs in Python
Includes text classification and clustering techniques
Informs the reader about different types of neural networks for text analysis
Includes advanced analytical techniques such as fuzzy logic and deep learning techniques
Explains concepts in a simplified and structured way that is ideal for learners
Includes References for further reading
Text Analysis with Python: A Research-Oriented Guide is an ideal guide for students in data science and computer science courses and for researchers and analysts who want to work on artificial intelligence projects that require the application of text mining and NLP techniques.
Textbook of Advanced Dermatology: Pearls for Academia and Skin Clinics (Part 1)
Textbook of Advanced Dermatology: Pearls for Academia and Skin Clinics is an essential reference for practicing dermatologists in hospitals and clinics. The book aims to provide interesting tips that cannot be found in traditional dermatology handbooks. The contributors include top minds in dermatology and related fields such as Joe Niamtu Samuel Lam and Steven Feldman. Topics in the book include novel original formulations for topical compounds ways to improve patient adherence to prescriptions business tips novelties in skin surgery and solutions for preventing patient complaints and legal suits. The book also highlights the author's personal experiences gained over many years in improving everyday clinical dermatology practice.
The book is divided into 5 sections each representing 'pearls' of advice: Teaching Pearls Medical Pearls Publication Pearls Procedural Pearls and Business Pearls encompassing all of the broad realm of dermatology.
Textbook of Advanced Dermatology: Pearls for Academia and Skin Clinics (Part 2)
Textbook of Advanced Dermatology: Pearls for Academia and Skin Clinics is an essential reference for practicing dermatologists in hospitals and clinics. The book aims to provide interesting tips which cannot be found in traditional dermatology handbooks. The contributors include top minds in dermatology and related fields such as Joe Niamtu Samuel Lam and Steven Feldman. Topics in the book include novel original formulations for topical compounds ways to improve patient adherence to prescriptions business tips novelties in skin surgery and solutions for preventing patient complaints and legal suits. The book also highlights the authors personal experiences gained over many years in improving everyday clinical dermatology practice.
The book is divided into 5 sections each representing pearls of advice: Teaching Pearls Medical Pearls Publication Pearls Procedural Pearls and Business Pearls encompassing all of the broad realm of dermatology.
Therapeutic Implications of Natural Bioactive Compounds
This volume is a comprehensive compilation of contributions on the state of art knowledge about bioactive compounds including their sources isolation methods biological effects health benefits and potential applications. These bioactive compounds could serve as alternatives in the prevention or treatment of multifactorial diseases for vulnerable population groups.
Chapters in the book incorporate the knowledge based on traditional medicine with recent findings on bioactive molecules and their pharmaceutical implications in neurodegenerative diseases cancer COVID 19 diabetes immunomodulation and farm animal diseases.
The book also highlights the latest breakthroughs in the field of screening characterization and novel applications of natural bioactive compounds from diverse group of organisms ranging from bacteria algae fungi higher plants and marine sources.
Authors from renowned institutions of India Japan and China have shared their e
It is an informative reference for researchers professors graduate students science enthusiasts and all those who wish to gain insights into various aspects of bioactive compounds and development of new pharmacological active constituents and nutritional science.
Therapeutic Nanocarriers in Cancer Treatment: Challenges and Future Perspective
Nanotechnology has revolutionized cancer diagnosis and therapy through targeted drug delivery. Advances in protein engineering and materials science have led to the development of nanocarriers (NCs) which have helped overcome the challenges faced during conventional cancer treatment. These nanocarriers serve as an efficient transport module for drugs. Nano-drug delivery has emerged as a promising technology that results in early detection and better treatment of various cancers. The approved nanoparticles currently used in cancer treatment strategies include liposomes dendrimers polyplexes solid lipid nano-carriers etc. These nanocarriers shall provide a quick safe and cost-effective method in cancer therapy and management. This book contains thirteen chapters focusing on the treatment of various cancers i.e. lung breast cervical ovarian colon prostate head and neck etc. through nanocarrier drugs. The chapters include reviews on a wide variety of advanced data from existing and ongoing clinical research and major regulatory considerations.
Thermal Cycles of Heat Recovery Power Plants
Thermal Cycles of Heat Recovery Power Plants presents information about thermal power plant cycles suitable for waste heat recovery (WHR) in modern power plants. The author covers five thermal power cycles: organic Rankine cycle (ORC) organic flash cycle (OFC) Kalina cycle (KC) steam Rankine cycle (SRC) and steam flash cycle (SFC) with the working fluids of R123 R124 R134a R245fa R717 and R407C. The handbook helps the reader to understand the latest power plant technologies suitable for utilizing the waste heat generated by thermal industrial processes.
Key Features:
- Comprehensive modeling simulation analysis and optimization of 5 power cycle types with different working fluids
- Clear information about the processes and solutions of thermal power cycles to augment the power generation with improved energy conversion.
- Simple reader friendly presentation
- bibliographic references after each chapter for further reading
This handbook is suitable for engineering students in degree courses and professionals in training programs who require resources on advanced thermal power plant operation and optimal waste heat recovery processes respectively. It is also a handy reference for energy conversion efficiency in heat recovery power plants. The book is also of interest to any researchers interested in industrial applications of thermodynamic processes.
Thermal Spray Coatings: Materials, Techniques & Applications
This comprehensive book explores the techniques materials and real-world applications of thermal spray coatings across various industries including power generation aerospace medical and automotive sectors.
Readers will learn about the basic science and engineering aspects of thermal spray technology its historical developments and the diverse range of materials used from metallic to ceramic materials and nano-crystallization materials. Distinct thermal spray techniques are explained (flame spray detonation-gun spray high-velocity oxy-fuel spray electric arc spray plasma spray and cold spray). Chapters on advanced topics also give an understanding of crucial material properties such as high temperature corrosion oxidation erosion or wear resistance and biocompatibility.
Key features
- Contributions from materials science experts with references for each topic
- Gives a comprehensive overview of materials and distinct spray techniques used in thermal coatings
- Dedicated chapters for applications of thermal coatings in different industries
- Covers recent trends and new advances such as surface modification techniques to improve functionality and performance
This book is intended as a resource for an in-depth understanding of the fundamentals and applications of thermal spray coatings for students professionals and researchers in materials science and chemical engineering disciplines.
Thin Film Nanomaterials: Synthesis, Properties and Innovative Energy Applications
Thin Film Nanomaterials: Synthesis Properties and Innovative Energy Applications provides a comprehensive overview of the synthesis properties and cutting-edge applications of thin film nanomaterials. Each chapter explores different aspects of thin film synthesis and its application in energy devices showcasing different metal-based and carbon nanomaterials .
The book begins with a discussion on the synthesis and characterization of cadmium and zinc sulphide thin films for opto-electronics energy devices. Subsequent chapters delve into critical reviews of CIGS thin film nanomaterials deposition techniques for metal oxide nanocomposite films and nanostructured TiO2@carbon films for photocatalytic applications.
Bandgap engineering optical properties of composite films and recent advancements in metal oxide thin films are also covered. Additionally the synthesis and characteristics of iron oxide films for solar cell and green energy storage applications are discussed.
Chapters on challenges and future prospects of CNT-based cathode emitters and advanced characterizations of nanocrystalline ferrimagnetic thin films provide valuable insights into emerging technologies.
This book is an essential resource for professors scientists engineers research scholars postdocs and undergraduate/graduate students seeking to explore the forefront of nanomaterials and their applications in energy systems.
Thriving Across the Lifespan and Around the Globe: Day in the Life Visual Research Approach
Thriving Across the Lifespan and Around the Globe: Day in the Life Visual Research Approach is the result of several decades of international pan-disciplinary research-team collaborations using quasi-ecological visual methodologies to investigate the psychosocial development of children in diverse communities. The initial studies highlighted in this work involved filming a Day in the Life of toddlers and primary school children their families and schools in diverse communities in Asia South and North America and Europe. Filmed in their homes and communities for an entire day the youngest participants were commonly seen to be thriving in diverse psychosocial domains such as in their security strivings emergent literacy and graphic representations and musicality. Research shows that the nature of a child's development can vary in as many ways as there are diverse contexts. Thriving in the transition from home to primary school is a second developmental milestone investigated in the research.
The book serves as an account of the lived experiences of thriving childrenamong their families their schools and their communities. The contents give an invaluable insight into the psychology of early childhood while giving the reader an opportunity to understand the resilience of mobile early teenagers as well as independent older adults. The contributions in the book also provide an additional layer to our understanding of visual ethnography by covering such phenomena as agency and communitarianism spirituality and the place of humour in the context of challenges encountered across the lifespan. Through presenting quasi-ecological experimental approaches this reference enhances the readers insight into the texture and nature of thriving in situ in natural contexts.
Thrombosis and Inflammation in Acute Coronary Syndromes
Despite remarkable progress in fighting against myocardial infarction the thrombotic complications of the coronary artery are still a significant cause of morbidity and mortality worldwide. Treatment options for arterial thrombosis include either relatively old drugs such as streptokinase and newer agents that are either approved by the FDA or still undergoing clinical trials. These options make some room for questions that lead to a conclusion for the best combination of drugs for treating patients with acute coronary syndromes.
The handbook combines available information from basic hematology cardiology and clinical trials and presents practical bed-side solutions for clinicians working with patients suffering from acute coronary syndromes. Readers will learn about the pathogenesis and diagnosis of thrombosis thrombogenesis and fibrinolysis. Newer antithrombotic agents cardiac diseases venous thromboembolism are also covered. Health professionals will have quick access to relevant and organized information which also includes visual and tabular guides as well as some recommendations from professional societies.
Thyroid Ultrasonography and Fine Needle Aspiration Biopsy: A Practical Guide and Picture Atlas
Thyroid Ultrasonography and Fine Needle Aspiration Biopsy: A Practical Guide and Picture Atlas is a concise and visual reference for diagnostic ultrasonography and needle biopsy of the human thyroid gland. The book provides the reader essential information on how to 1) distinguish between normal and abnormal thyroid sonograms 2) differentiate low suspicion for malignancy thyroid nodules from sonographically high suspicion nodules 3) evaluate cervical lymph nodes and parathyroid glands and 4) examine post-thyroidectomy patients with differentiated thyroid cancer. The reader is also introduced to the different thyroid nodule risk stratification systems in ultrasound imaging when and how to perform thyroid fine needle aspiration biopsies and the use of percutaneous ethanol injections for cystic thyroid nodules.
Key Features:
-11 chapters which begin with an introduction to thyroid ultrasound and progressively explain relevant diagnostic imaging and biopsy procedures for different thyroid diseases (including thyroid cancer and autoimmune diseases)
-multiple tables and figures which summarize and highlight important points
-more than 60 ultrasound images which illustrate various ultrasound signs and artefacts from patients
-a summary of the current standards for the evaluation and clinical management of thyroid nodules based on clinical practice guidelines
-a detailed list of references abbreviations and symbols
The textbook is an essential reference for both practicing and training endocrine surgeons endocrinologists radiologists cytopathologists sonographers as well as any health care worker with an interest in managing thyroid and parathyroid diseases in their daily practice.
Thyroid and Brain: Understanding the Actions of Thyroid Hormones in Brain Development and Function
This comprehensive textbook offers an in-depth exploration of how thyroid hormones influence brain development and function particularly on cellular and molecular mechanisms. Readers will find current insights into the complex interplay between the thyroid and neurological systems making it a valuable resource for researchers advanced learners and clinicians in the fields of endocrinology neuroscience and developmental biology.
The book starts with a review of thyroid physiology setting the stage for subsequent chapters that cover specific topics such as the impact of maternal thyroid hormones on fetal brain development and the effects of iodine deficiency. From here the book progresses to cover the regulation of brain gene expression neuronal and glial cell differentiation and myelination by thyroid hormones and how thyroid hormones shape the brain. Finally the book addresses the link between thyroid dysfunction and mood disorders.
Key features
- A thorough examination of the historical and the latest research findings through 14 chapters
- Clear explanations of molecular pathways
- Emphasis on both theoretical knowledge and practical applications
- Detailed and research-focused content scientific references for further reading
Topics in Anti-Cancer Research: Volume 10
Topics in Anti-Cancer Research covers new developments in the field of cancer diagnosis and drug therapy. Novel drugs as anticancer agents include natural and synthetic phenazirines and other anti-cancer compounds. The series also covers information on the current understanding of the pathology and molecular biology of specific neoplasms.
The diversity of research topics published in this book series give broad and valuable perspectives for cancer researchers clinicians cancer professionals aiming to develop novel anti-cancer targets and patents for the treatment of various cancers.
The topics covered in this volume are:
- Peptides can play a major role in combating cancer diseases
- Studying of the CLL after treatment using fractal parameter of neoplastic lymphocytes detection (ΛNLD)
- Mechanistic insight of rhenium-based compounds as anti- cancer agents
- Targeting cancer-specific inflammatory components in cancer therapeutics
- Marine natural products as a source of novel anticancer agents: a treasure from the ocean
- PDX clinical trial design in anti-cancer research
Toward the Future: The New Challenges of the Cell Therapy and Potential of Regenerative Medicine
Cells are the building blocks of life and some cells (stem cells) have the ability to produce other cells through the processes of cell division and cell differentiation. Stem cell research has now progressed dramatically and there are countless studies published every year in scientific journals. Stem cell technology is being used to create new cell lines with edited genes and to regenerate cell based tissues for biological and medical purposes.
This ebook presents a brief snapshot of clinical research in stem cell research and regenerative medicine. The concise reference is intended to be an introduction for biology students to current standards and new technologies in these fields.
Towards a Modeling Synthesis of Two or Three-Dimensional Circuits Through Substrate Coupling and Interconnections: Noises and Parasites
The number of transistors in integrated circuits doubles every two years as stipulated by Moores law and this has been the driving force for the huge development of the microelectronics industry in the past 50 years currently advanced to the nanometric scale.
This e-book is dedicated to electronic noises and parasites accounting for issues involving substrate coupling and interconnections in the perspective of the 3D integration: a second track for enhancing integration also compatible with Moores law. This reference explains the modeling of 3D circuits without delving into the latest advances but highlights crucial problems for instance electro-thermo-mechanical problems which could be addressed through 3D modeling. The book also explains electromagnetic interferences at different modeling levels (device and circuit) oriented towards 3D integration technologies. It also covers substrate noise such as disturbances of digital blocks power bounces phase noise in oscillators both at the device level such as carriers or field fluctuations and circuit levels. The entanglement between interconnect and substrate is also discussed.
This e-book serves as a reference for advanced graduates or researchers in the field of micro and nano electronics interested in topics relevant to electromagnetic interference or the noise domain at device or circuit and system levels