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Keeping up with Genome Sequence and Expression
Genome science or genomics is essential to advancing knowledge in the fields of biology and medicine. Specifically researchers learn about the molecular biology behind genetic expression in living organisms and related methods of treating human genetic diseases (including gene therapy). Advances in Genome Science is an e-book series which provides a multi-disciplinary view of some of the latest developments in genome research allowing readers to capture the essence and diversity of genomics in contemporary science.
The third volume of this ebook series features a variety of articles exploring oncogenomics mouse genetics feline genetics genetic mechanism for pain the genetics of weeds and much more.
Key Heterocyclic Cores for Smart Anticancer Drug–Design Part I
This book provides an update on heterocyclic compounds that serve as key components of anti-cancer agents administered in pre-clinical settings. Many of the compounds highlighted in the book are being actively investigated for the bioactive properties against a range of cancer cell lines. There is potential for heterocyclic compounds to design agents that can target specific molecules to treat different types of cancers. Chapters are contributed by experts in pharmaceutical chemistry and are written to give a general overview of the topic to readers involved in all levels of research and decision-making in pharmaceutical chemistry and anti-cancer drug design.
Part 1 of the book set covers these topics:
- Heterocyclic anticancer compounds derived from natural sources with their mechanism of action
- The role of terpenoids as anticancer compounds: an insight into prevention and treatment
- Recent advances in synthesis and anticancer activity of benzothiazole hybrids as anticancer agents
- Structure-activity relationship studies of novel hybrid quinoline and quinolone derivatives as anticancer agents
- Tetrazoles: structure and activity relationship as anticancer agents
- Progress in nitrogen and oxygen-based heterocyclic compounds for their anticancer activity: an update (2017-2020)
Key Heterocyclic Cores for Smart Anticancer Drug–Design Part II
This book provides an update on heterocyclic compounds that serve as key components of anti-cancer agents administered in pre-clinical settings. Many of the compounds highlighted in the book are being actively investigated for the bioactive properties against a range of cancer cell lines. There is potential for heterocyclic compounds to design agents that can target specific molecules to treat different types of cancers. Chapters are contributed by experts in pharmaceutical chemistry and are written to give a general overview of the topic to readers involved in all levels of research and decision-making in pharmaceutical chemistry and anti-cancer drug design.
Part II of the book set covers these topics:
- Anticancer targets for heterocyclic lead compounds
- Coumarin hybrids for cancer treatments - Progress in nitrogen and sulphur-based heterocyclic compounds for their anticancer activity
- Imidazole as an anticancer heterocyclic ring - Morpholine for profiling anticancer lead compounds
- Natural products as anticancer agents
Kidney Disease in Diabetes
This reference work provides comprehensive information about diabetic nephropathy. Chapters in the book introduce the reader to the link between diabetes obesity and chronic kidney disease (CKD) and delve into many topics relevant to treating kidney disease in diabetic patients. These topics include CKD epidemiology diagnosis treatment considerations for the elderly patient post-transplant diabetes pathophysiology biomarkers and much more. Special topics such as the incidence of cardiovascular disease in diabetic CKD nutrition for obese CKD patients and the clinical use of biomarkers for evaluating cases are also included.
The broad spectrum coverage of informative topics about diabetic kidney disease make this an essential reference for medical students and clinical residents/healthcare professionals in nephrology endocrinology geriatrics internal medicine and general surgery. Researchers interested in the clinical biochemistry of diabetes and associated disorders will also benefit from the information presented.