Mini-Reviews in Organic Chemistry - Volume 22, Issue 2, 2025

This review focuses on studying hydrogen bonds in triflamide derivatives, the supramolecular structures formed in a crystal, solution, and gas phase, and the relationship between structural, spectral and quantum chemical calculation data.

Heterocyclic compounds are the most common and diverse group of organic substances. Heterocyclic compounds are rapidly increasing in number as a result of intensive synthetic research as well as their value in other synthetic procedures. More than 90% of medications contain heterocyclic rings, and a wide range of medicinal chemistry applications make use of these substances. There are always unique characteristics of a Read More

2-(Arylidene)benzo[b]thiophen-3(2H)one 1,1-dioxides are oxidized form of thioaurones. Various methods have been reported for their synthesis, e.g., a) condensation of benzo[b]thiophen-3(2H)one 1,1-dioxides with aryl aldehydes under acidic or basic conditions, b) oxidation of thioaurones with hydrogen peroxide or sodium perborate tetrahydrate, c) from the catalytic reaction of iodonium ylides with (bis(trifluoroacetoxy)iod Read More

The cinnoline nucleus is a bicyclic ring and is an isosteric precursor to quinolone or isoquinoline. Cinnoline analogs are aromatic heterocyclic compounds having diverse therapeutic activities, such as antimicrobial, analgesic, anti-inflammatory, anti-tuberculosis, antimalarial, anticonvulsant, antioxidant, anticancer, antihypertensive, anti-anxiety, and other activities. This heterocyclic nucleus is attracting a lot of attention in me Read More

Asciminib, also known as ACP-196, is the FDA-approved low-molecular ABL kinase inhibitor. The ABL kinase is a non-receptor tyrosine kinase that helps in cell growth and survival and is a key player in the development of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL). The BCR-ABL fusion protein, which is formed by chromosomal translocation in CML and Ph+ AL Read More

The secondary metabolites produced by fungi are an important resource for new drug development, and the biosynthesis of fungal secondary metabolites is closely related to the epigenetic status of the chromosomes in which their gene clusters are located. However, the induction of fungal silencing of gene expression is one of the challenges faced at this stage. Chemical epigenetic modification is a simple and effectiv Read More

The last decades have witnessed significant advances in the synthesis of bioactive carbohydrates. As in all fields of organic synthesis, the search for more environmentally friendly alternative synthetic methods is a current and expanding concern. Consequently, electrochemical organic synthesis has emerged as an efficient and sustainable methodology. Herein, we present recent developments in the synthesis of glycosides and ot Read More

Sea salt is a widely used ingredient in culinary practices around the world. Beyond its flavor-enhancing properties, sea salt has been recognized for its potential health benefits. This review aimed to explore the role of sea salt in food and its applications for promoting human health. We have discussed the composition and production of sea salt, its culinary uses, and its impact on various aspects of human health, including car Read More

Aurones are structural isomers of flavones and flavonols with the basic C6–C3–C6 skeleton arranged as (Z)-2-benzylidenebenzofuran-3(2H)-one, which contain an exocyclic carbon-carbon double bond bridging the benzofuranone and phenyl rings. In aurone, a chalcone-like group is closed into a 5-membered ring instead of the 6-membered ring more typical of flavonoids, which forms the core for a family of derivatives that are Read More

Primary photoreactions of riboflavin (Rf) are considered. The goal was to present data on the transients formed under photoexcitation of Rf: excited singlet and triplet states, triplet reactions with the formation of Rf neutral free radicals, and a radical anion. The absorption spectra of transients are presented, as are the rate constants of their decay. Special attention is devoted to Rf in water (aerobic and anaerobic reactions).