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The biological and medicinal properties of thieno[3, 2-c] quinoline have prompted enormous research aimed at developing synthetic routes for these systems. This review focuses on the chemical properties associated with this system. The most reported reactions are Bischler- Napieralski, Suzuki−Miyaura−Schlüter, Pictet-Spengler, Stille coupling and Friedlander and Beckmann rearrangement reaction.