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2000
Volume 4, Issue 1
  • ISSN: 1570-193X
  • E-ISSN:

Abstract

We developed a novel technology for core-corona polymeric nanoparticles having hydrophilic polymer chains with functional groups. Polystyrene nanoparticles immobilized with the mannose-specific lectin concanavalin A could efficiently capture human immunodeficiency virus type 1 (HIV-1) particles and gp120 antigens on their surface. Since the antigen-capturing nanoparticles were capable of inducing humoral and cellular immune responses to HIV-1, they could be developed as a mucosal vaccine against HIV-1 infection.

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/content/journals/mroc/10.2174/157019307779815857
2007-02-01
2024-11-23
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/content/journals/mroc/10.2174/157019307779815857
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  • Article Type:
    Research Article
Keyword(s): concanavalin A; HIV-1; mucosal vaccine; Polystyrene nanoparticles
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