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Development of Core-Corona Type Polymeric Nanoparticles as an Anti-HIV-1 Vaccine
- Source: Mini-Reviews in Organic Chemistry, Volume 4, Issue 1, Feb 2007, p. 51 - 59
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- 01 Feb 2007
Abstract
We developed a novel technology for core-corona polymeric nanoparticles having hydrophilic polymer chains with functional groups. Polystyrene nanoparticles immobilized with the mannose-specific lectin concanavalin A could efficiently capture human immunodeficiency virus type 1 (HIV-1) particles and gp120 antigens on their surface. Since the antigen-capturing nanoparticles were capable of inducing humoral and cellular immune responses to HIV-1, they could be developed as a mucosal vaccine against HIV-1 infection.
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