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Renoprotective Effects of Eugenol-Loaded Chitosan Nanoparticles on Septic Rats
Available online: 04 February 2025More LessBackground Sepsis is a severe medical disorder that poses a significant risk to life, leading to elevated rates of sickness and mortality globally, reaching 11 million annually. It is distinguished by an imbalanced immune response to infection, which subsequently causes failure in several organs. Eugenol is obtained from clove oil and possesses various beneficial properties, such as antifungal, anti-inflammatory, antiviral, a Read More
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Pleiotropic Leukemia Inhibitory Factor Encapsulated in DODAB:MO Liposomes for Multiple Biomedical Applications
Available online: 14 January 2025More LessIntroduction The development of novel drug carriers is invaluable to maximize therapeutic efficiency and improve specificity. Dioctadecyl-dimethylammonium bromide (DODAB): monoolein (MO) (1:2) liposomes exhibit non-lamellar phases in their core that improve the encapsulation ability of both hydrophobic and hydrophilic molecules. This study explores the use of this nanosystem for the therapeutic delivery of cyto Read More
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Design and Development of Nanoparticle-loaded In-situ Gel for Enhanced and Sustained Ophthalmic Delivery
Authors: Anupriya D’Souza and Raghuvir R.S. PissurlenkarAvailable online: 13 December 2024More LessBackground Flurbiprofen, a non-selective COX inhibitor utilized for managing mild to moderate pain and inflammation, operates through reversible inhibition of both COX-1 and COX-2 pathways. However, as a BCS class II drug, it exhibits limited aqueous solubility, leading to suboptimal ocular bioavailability and a brief corneal contact. Objective The goal of this study was to amplify the aqueous solubility of Flurbiprofen by formu Read More
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Inulin: A Versatile Biopolymer for Pharmaceutical Application
Available online: 13 December 2024More LessFor many years, inulin has been a versatile oligosaccharide that is mainly utilized in food. When compared to other biodegradable polysaccharides, inulin's unique and flexible structure, protective/stabilizing properties, along with organ-targeting abilities make it an ideal drug delivery vehicle. Inulin has drawn a lot of attention as a promising multifunctional natural biopolymer with a wide range of uses in drug delivery, prebiotic Read More
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Nanotheranostic Approach for Targeting Tauopathies in Alzheimer's Disease: Mechanistic Insight and Recent Advances
Authors: Kantrol Kumar Sahu, Ruchi Chaudhary, Mohd. Asad Farooqi and Monika KauravAvailable online: 26 November 2024More LessThe most prevalent type of dementia, Alzheimer's disease (AD), is typified by the presence of intracellular tau protein neurofibrillary tangles and extracellular amyloid plaques. There are currently about 50 million people who have dementia, and by 2030, that number is predicted to rise to 75 million, placing a significant financial strain on the nation's healthcare system. Novel disease-modifying treatments are desperately need Read More
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Development and Optimization of Transferosomal Gel for Efficient Topical Delivery of Berberine Hydrochloride
Available online: 01 November 2024More LessBackground Berberine is an isoquinoline alkaloid with potent anti-inflammatory effects. However, its therapeutic efficacy is often restricted by its poor solubility, absorption, and permeability, especially in topical applications. Transferosomes are elastic vesicular carriers with high skin permeability values and retention, making them suitable for encapsulating hydrophilic and lipophilic actives. Objective The objective of t Read More
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Advanced Technologies in Rectal Drug Delivery Systems: A Comprehensive Review of Recent Innovations and Future Prospects
Available online: 31 October 2024More LessRectal Drug Delivery System (RDDS) emerges as an alternative administration route due to the rectum's small surface area and limited enzyme activity, which contribute to efficient drug absorption. RDDS offers various advantages, such as reduced first-pass metabolism, rapid absorption of low molecular weight drugs, and the ability to accommodate large retention volumes and facilitate absorption via the lymphatic system. Read More
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3D and 4D Technology for Pharmaceutical Drug Delivery: A Detailed Insight
Authors: Shashank Soni, Vivek Yadav, Dhananjay Kumar and Sandeep Kumar TiwariAvailable online: 17 October 2024More Less3D Printing, sometimes referred to as additive manufacturing, has made the concept of personalized medicine a reality. The primary objective of 3D and 4D printing is to produce intricate, customized pharmaceuticals at a reasonable cost. With improvements in materials, resolution, and speed, 3D printing technology is quickly developing. It includes faster construction, cost efficiency through reduced waste, design flexibili Read More
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Hydrogels Innovation: A Review on Recent Development, Characterization, and Applications
Authors: Vikram Ahirwar and Dharmendra JainAvailable online: 17 October 2024More LessHydrogels are special materials that can hold a large amount of water and form 3D networks. In the past few years, there have been exciting improvements in hydrogel technology, bringing new ideas to many different areas. By trying out new materials like smart hydrogels that can respond to different conditions, provided new ways to deliver medicine precisely, build tissues, and create wearable gadgets. Among the Read More
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A Comprehensive Review on Role of Natural Polymers in Gastro Retentive Drug Delivery System (GRDDS)
Authors: Manisha Singh and Manas Kumar DasAvailable online: 14 October 2024More LessThis review is to present a general outline of potent & promising natural polymers (on which only slight research is done) along with their attributes & their pharmaceutical functions in the development of GRDDS (gastro retentive drug delivery system). Therefore, there is a need of more attention & focus on some of these natural polymers which are playing a crucial & indispensable role in the fabrication of GRDDS. Recen Read More
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