Drug Delivery Letters - Current Issue

Drugs that have been covalently altered with lipids are known as lipid-drug conjugates. Drug characteristics are altered and their lipophilicity is increased when lipids are conjugated to drug molecules. The conjugates exhibit a number of benefits, including increased oral bioavailability, improved lymphatic targeting, improved tumor targeting, and reduced cytotoxicity. Different conjugation techniques and chemical bridg Read More

Raloxifene hydrochloride belongs to the selective estrogen receptor modulator category. Initially, US FDA approved its use for the prevention and treatment of osteoporosis in post-menopausal women. Later, raloxifene hydrochloride was also approved for the prevention of invasive breast carcinoma in post-menopausal women under the high-risk category. Despite its immense and diverse therapeutic potential, the oral bio Read More

BackgroundThe preparation of nanoparticles with the efficiency of treatment and diagnosis at the same time has received more and more attention in recent years. Metal nanoparticles are one of the best candidates for this purpose.MethodsSilver sulfide nanoparticle (Ag2S) coated with chitosan was synthesized and then methotrexate was loaded, and then the anticancer property of the synthesized nanoparticles was ex Read More

BackgroundUncomplicated skin and soft tissue infections account for approximately 200 million visits to ambulatory care settings annually. Linezolid (LNZ) is an oxazolidinone that has proven its effectiveness in combating skin and soft tissue infections caused by gram-positive pathogens. LNZ is administered via oral suspension, tablets, or an intravenous route in most instances. However, its extended therapy leads to undesirable Read More