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This review is to present a general outline of potent & promising natural polymers (on which only slight research is done) along with their attributes & their pharmaceutical functions in the development of GRDDS (gastro retentive drug delivery system). Therefore, there is a need of more attention & focus on some of these natural polymers which are playing a crucial & indispensable role in the fabrication of GRDDS. Recent & current research trends shows that progressively natural polymers are replacing synthetic polymers in the fabrication of GRDDS as they are more safe, non-toxic, biodegradable, biocompatible, economical, regulatory acceptance, etc. Also, it has been noticed by the researchers that natural polymer due to their properties have successfully amplified gastric residence time, dissolution & bioavailability of the gastroretentive dosage forms.
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