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- Volume 30, Issue 8, 2024
Current Pharmaceutical Design - Volume 30, Issue 8, 2024
Volume 30, Issue 8, 2024
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Pharmacological Considerations during Percutaneous Treatment of Heart Failure
Heart Failure (HF) remains a global health challenge, marked by its widespread prevalence and substantial resource utilization. Although the prognosis has improved in recent decades due to the treatments implemented, it continues to generate high morbidity and mortality in the medium to long term. Interventional cardiology has emerged as a crucial player in HF management, offering a diverse array of percuta Read More
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Efficacy and Safety Analysis of Botox Application and Iatrogenic Botulism: Panacea or Peril?
Authors: Ozgur Karcioglu, Canan Akman and Ilknur AtnisClostridium botulinum toxin-A (BoNT-A) creates temporary paralysis in the muscles by acting on the muscle-nerve junction. It is injected into the mimic muscles when a decrease in the movements of the mimic muscles is desired. Despite many favorable applications, the use of BoNT-A is not without drawbacks. Although there is no expected serious side effect on health in BoNT-A treatments, various problems can be encount Read More
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Relationship between Compound α-Ketoacid and Microinflammation in Patients with Chronic Kidney Disease
Authors: Zaobin Chen, Yongda Lin, Jiali Wang, Kaijin Yao, Yina Xie, Xiutian Chen and Tianbiao ZhouChronic kidney disease (CKD) refers to the presence of structural or functional abnormalities in the kidneys that affect health, lasting for more than 3 months. CKD is not only the direct cause of global incidence rate and mortality, but also an important risk factor for cardiovascular disease. Persistent microinflammatory state has been recognized as an important component of CKD, which can lead to renal fibrosis and loss of Read More
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2,5-Diketopiperazines (DKPs): Promising Scaffolds for Anticancer Agents
Authors: Shaimaa S. Goher, Wessam S. Abdrabo, Giri Babu Veerakanellore and Bahaa Elgendy2,5-Diketopiperazine (2,5-DKP) derivatives represent a family of secondary metabolites widely produced by bacteria, fungi, plants, animals, and marine organisms. Many natural products with DKP scaffolds exhibited various pharmacological activities such as antiviral, antifungal, antibacterial, and antitumor. 2,5-DKPs are recognized as privileged structures in medicinal chemistry, and compounds that incorporate the 2,5-DKP sc Read More
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The Potential of Natural Products in the Management of Cardiovascular Disease
Authors: Harshita Singhai, Sunny Rathee, Sanjay K. Jain and Umesh Kumar PatilCardiovascular Disease (CVD) is one of the most prevalent diseases in the world, comprising a variety of disorders such as hypertension, heart attacks, Peripheral Vascular Disease (PVD), dyslipidemias, strokes, coronary heart disease, and cardiomyopathies. The World Health Organization (WHO) predicts that 22.2 million people will die from CVD in 2030. Conventional treatments for CVDs are often quite expensive and also Read More
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Roles of AFAP1-AS1 in Gynecology and Urogenital System
Authors: Xinyan Qiu, Yulin Huang, Lin Jin, Canying Yang and Jiwei WangBackground Human disease onset and progression are strongly associated with aberrant long non- coding RNA (lncRNA) expression, highlighting the functional regulatory role of lncRNA. Actin filament-associated protein 1-antisense RNA 1 (AFAP1-AS1), a member of lncRNAs, is located on the antisense strand of Actin filament-associated protein 1 (AFAP1). Methods We conducted a comprehensive review of AFAP1-AS1's functio Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
- Issue 42
- Issue 41
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- Issue 1
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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