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- Volume 30, Issue 29, 2024
Current Pharmaceutical Design - Volume 30, Issue 29, 2024
Volume 30, Issue 29, 2024
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Current Insights in Murine Models for Breast Cancer: Present, Past and Future
Authors: Mansi Jain and Anjana GoelBreast cancer is an intricate disease that is increasing at a fast pace, and numerous heterogeneities within it further make it difficult to investigate. We have always used animal models to understand cancer pathology and create an in vivo microenvironment that closely resembles human cancer. They are considered an indispensable part of any clinical investigation regarding cancer. Animal models have a high potency in i Read More
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Exploring the Therapeutic Potential of Triptonide in Salivary Adenoid Cystic Carcinoma: A Comprehensive Approach Involving Network Pharmacology and Experimental Validation
Authors: Shikai Geng, Li Chen, Wanzun Lin, Fangzhu Wan, Ziyu Le, Wei Hu, Huaiyuan Chen, Xingyu Liu, Qingting Huang, Haojiong Zhang, Jiade J. Lu and Lin KongBackground: Salivary Adenoid Cystic Carcinoma (ACC) is characterized by a highly invasive and slow-growing pattern, and its etiology remains unidentified. Triptonide (TN) has demonstrated efficacy as a pharmacotherapeutic agent against ACC. Nonetheless, the specific targets and mechanism of molecular action underlying the effectiveness of TN in treating ACC have not been elucidated. Objectives: By integrating Read More
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Effects of Sex Differences and Combined Use of Clozapine on Initial Dosage Optimization of Valproic Acid in Patients with Bipolar Disorder
Authors: Wei Shen, Ke Hu, Hao-Zhe Shi, Lei Jiang, Yi-Jia Zhang, Su-Mei He, Cun Zhang, Xiao Chen and Dong-Dong WangBackground: Due to the narrow therapeutic window and large pharmacokinetic variation of valproic acid (VPA), it is difficult to make an optimal dosage regimen. The present study aims to optimize the initial dosage of VPA in patients with bipolar disorder. Methods: A total of 126 patients with bipolar disorder treated by VPA were included to construct the VPA population pharmacokinetic model retrospectively. Sex differences a Read More
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Matrine-loaded Nano-liposome Induces Apoptosis in Human Esophageal-squamous Carcinoma KYSE-150 Cells
Authors: Kai Zhao, Yun Cai, Faisal Raza, Hajra Zafar, Liang Pan, Xifeng Zheng, Wenjie Xu, Ran Li, Feng Shi and Yongbin MaIntroduction: Esophageal-squamous Cell Carcinoma (ESCC) is often diagnosed at the middle or late stage, thus requiring more effective therapeutic strategies. Pharmacologically, the anti-tumor activity of the principal active constituent of Sophora flavescens, matrine (MA), has been explored widely. Notwithstanding, it is significant to nanotechnologically enhance the anti-tumor activity of MA in view of its potential to distribute Read More
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Elemene Injection Overcomes Paclitaxel Resistance in Breast Cancer through AR/RUNX1 Signal: Network Pharmacology and Experimental Validation
Authors: Xidong Gu, Leilai Xu, Yuanyuan Fu, Shuyao Fan, Tianjian Huang, Jiangting Yu, Jiaying Chen, Xinbing Sui and Xiaohong XieBackground: Paclitaxel (PTX) is a cornerstone chemotherapy for Breast Cancer (BC), yet its impact is limited by emerging resistance. Elemene Injection (EI) has shown potential in overcoming chemotherapy resistance. However, the efficacy by which EI restores PTX sensitivity in BC and the implicated molecular mechanism remain uncharted. Methods: Network pharmacology and bioinformatic analysis were conducted to inv Read More
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Novel Therapies for ANCA-associated Vasculitis: Apilimod Ameliorated Endothelial Cells Injury through TLR4/NF-ΚB Pathway and NLRP3 Inflammasome
Authors: Siyang Liu, Chenlin Cao, Yiru Wang, Liu Hu and Qingquan LiuBackground: Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a rapidly progressive form of glomerulonephritis for which effective therapeutic drugs are currently lacking, and its underlying mechanism remains unclear. Aims: This study aimed to investigate new treatment options for AAV through a combination of bioinformatics analysis and cell molecular experiments. Methods: The research utilized integra Read More
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Volumes & issues
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Volume 31 (2025)
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Volume 30 (2024)
- Issue 42
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Volume 29 (2023)
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Volume 28 (2022)
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Volume 27 (2021)
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Volume 26 (2020)
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Volume 25 (2019)
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Volume 24 (2018)
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Volume 23 (2017)
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Volume 22 (2016)
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Volume 21 (2015)
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Volume 20 (2014)
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Volume 19 (2013)
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Volume 18 (2012)
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Volume 17 (2011)
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Volume 16 (2010)
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Volume 15 (2009)
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Volume 14 (2008)
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Volume 13 (2007)
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Volume 12 (2006)
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Volume 11 (2005)
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Volume 10 (2004)
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Volume 9 (2003)
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Volume 8 (2002)
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Volume 7 (2001)
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Volume 6 (2000)
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