Current Pharmaceutical Design - Volume 30, Issue 42, 2024

Additive manufacturing, sometimes referred to as 3D printing or AM, has numerous applications in industries like manufacturing, aviation, aerospace, vehicles, and education. It has recently made considerable inroads into the healthcare industry, backed by technology breakthroughs such as fused deposition modeling, binder jetting, and inkjet printing. A variety of biomaterials, such as polycaprolactone, polycarbonate Read More

BackgroundIntestinal dysfunction plays an important role in the clinical progress and prognosis of severe acute pancreatitis (SAP). Qingyi decoction (QYD) has shown beneficial effects on intestinal function recovery, but the prevention actions of the QYD on intestinal paralysis and its mechanism have not been fully explored.MethodsThe possible molecular mechanism was unraveled by network pharmacology, including active ingr Read More

BackgroundMicrovascular dysfunction develops in tissues after Ischemia-Reperfusion (IR). The current study aimed to determine the effect of naringin supplementation on kidney caspase-3, IL-1β, and HIF-1α levels and kidney histology in rats undergoing unilateral nephrectomy and kidney-ischemia reperfusion.MethodsThe study was conducted on 8-12 weeks old 40 Wistar-type male rats. Experimental renal ischemia-reperf Read More

AimsWe synthetized 10 hydroxylated and methoxylated chalcones and evaluated them targeting MMP-9 inhibition, looking for the rate of adhesion of H. pylori in gastric cells, and then, reduction of the inflammatory response as alternative therapeutic agents for controlling the infection.BackgroundHelicobacter pylori is a Gram-negative bacterium that chronically infects the human stomach, a risk factor for the Read More

ObjectiveTo uncover the potential hub targets of Kunkui Baoshen decoction (KKBS) in alleviating diabetic kidney disease (DKD).MethodsTargets associated with KKBS and DKD were curated from TCMSP, GeneCards, OMIM, and DisGeNET databases. Common targets were identified through intersection analysis using a Venn diagram. Employing the “Drug-component-target” approach and constructing a Protein-protein Intera Read More