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Volume 30, Issue 8
  • ISSN: 1381-6128
  • E-ISSN: 1873-4286

Abstract

Background

Human disease onset and progression are strongly associated with aberrant long non- coding RNA (lncRNA) expression, highlighting the functional regulatory role of lncRNA. Actin filament-associated protein 1-antisense RNA 1 (AFAP1-AS1), a member of lncRNAs, is located on the antisense strand of Actin filament-associated protein 1 (AFAP1).

Methods

We conducted a comprehensive review of AFAP1-AS1's functions in gynecology and urogenital systems using the “PubMed” database.

Results

Our analysis reveals that AFAP1-AS1 is overexpressed and engages in the initiation and process of gynecological and urogenital diseases. The regulatory mechanisms employed by AFAP1-AS1 involve four major strategies: gene-level effects, competition for microRNA (miRNA) repression, protein binding, participation in signaling networks that influence cellular processes such as proliferative phenotype, migration, invasiveness, epithelial-mesenchymal transition (EMT), cycle regulation, drug resistance, and more. Furthermore, AFAP1-AS1 is implicated in guiding clinicopathological characteristics.

Conclusion

AFAP1-AS1 holds promise as a potent diagnostics and treatment option for gynecological and genitourinary systems in the future.

© 2024 Bentham Science Publishers
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2024-03-01
2024-11-06

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Roles of AFAP1-AS1 in Gynecology and Urogenital System
Curr. Pharm. Des. 30, 639 (2024); https://doi.org/10.2174/0113816128286229240129090915
/content/journals/cpd/10.2174/0113816128286229240129090915
/content/journals/cpd/10.2174/0113816128286229240129090915
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  • Article Type: Review Article
Keyword(s): AFAP1-AS1; biomarker; gynecology; LncRNA; regulatory mechanisms; urogenital system

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