Current Organic Chemistry - Volume 8, Issue 17, 2004

Metabolites of the thermophilic fungi Myriococcum albomyces and Mycelia sterilia such as myriocin (1), the mycestericins (2-8) and the sphingofungins (13-18) structurally resemble the sphingosines, important components of cell membranes. All the compounds revealed in vitro remarkable immunosuppressive activity and their pharmaceutical potential has led to the development of promising novel immunosupp Read More

Regio- and stereoselective hydroxylation of non-activated carbon atom is a very important reaction, but it remains a significant challenge in classic chemistry. Biohydroxylation provides a useful alternative, and considerable progress has been made recently in the discovery of new catalysts and the improvement of catalysis by substrate engineering. High throughput screening of microorganisms with a miniaturized system enable Read More

In this review, recent application of trifluoroacetaldehyde ethyl hemiacetal (TFAE) in the preparation of α-trifluoromethyl alcohols and α-trifluoromethyl amines, especially by the direct regioselective and stereoselective substitution of TFAE and its derivatives like imines with various aromatic and heteroaromatic compounds, is reviewed. Moreover, some useful methods for preparing important potentially bioactive flu Read More

Phospholipases A2 constitute the major components from Bothrops snake venoms and have been extensively investigated not only because they are relatively very abundant in these venoms but mainly because they display a range of many relevant biological effects, including: myotoxic, cytotoxic, edemainducing, artificial membrane disrupting, anticoagulant, neuromuscular, platelet aggregation inhibiting, hypotensive, ba Read More

The marine sponges are the source of a unique group of natural products featuring a novel skeleton, the two indole rings were directed linked by a central heterocyclic moiety. Since topsentin, a bis(indolyl)imidazole, and its analogues were isolated from Topsentia genitrix about a decade ago, scientists have isolated various novel bis(indole) alkaloids from marine organisms especially from deep-water sponges in succession. Ov Read More

The redox chemistry of different quinones is focused to understand how the reduction products can be stabilized by supramolecular interactions or how they can react through different proton transfer mechanisms. This reactivity depends not only on the electronic properties of the substituents, but also on different structural effects related to the formation of intra and intermolecular hydrogen bonds. In order to explore a wider s Read More