Current Organic Chemistry - Volume 8, Issue 13, 2004

Conduritols are 1,2,3,4-cyclohexenetetrol isomers and exist in ten possible isomeric forms (two mesofour DL-pairs) and have been labelled A, B, C, D, E and F. All of the possible conduritol isomers have already been synthesised starting from completely different materials and their biological importance studied. Transformation of the aromatic compounds into diols has opened up a new synthetic approach to the various condu Read More

Synthesis of C-glycosides, C-linked saccharides and new glycosubstances has been the subject of considerable interest in carbohydrate, enzymatic and metabolic chemistry, since some of such compounds exhibit exciting biological properties. As a consequence, the design and implementation of stereo selective strategies for preparing bio-active carbohydrates became a prominent issue. This article is mainly aimed at the prese Read More

Polyhydroxylated alkaloids are frequently found in living systems. More than hundred compounds have been isolated from plants and microorganisms. Besides their utility as powerful tools in fundamental studies of the catalytic mechanism of glycosidases and glycosyltransferases, many natural polyhydroxylated alkaloids represent potential therapeutic agents. Due to the fact that very few compounds are commerc Read More

The synthesis of racemic 2-(4-{[4-(quinolin-2-ylmethoxy)phenyl]sulfanyl} phenyl)propionic acid (VUFB 20615) and preparation of 2-methyl-2-(4-{[4-(quinolin-2-ylmethoxy)phenyl]sulfanyl}phenyl)propionic acid (VUFB 20623) as new potential antileukotrienic drugs are described. Due to a low reactivity of the 4-substituted aryl bromides (coupling of the 4-substituted aryl bromides do not provide an activating functional group wi Read More

β-Oxophosphoranes / ylides, versatile intermediates in synthetic organic chemistry can be prepared by the novel reaction of P-aryl cyclic phosphine oxides, such as 2,3-dihydro- and 2,3,4,5-tetrahydro-1H-phosphole 1- oxides, as well as 1,2-dihydrophosphinine 1-oxides with dialkyl acetylenedicarboxylates (DAAD). The reaction involves a spirocyclic oxaphosphete intermediate formed by the (2+2) cycloaddition of th Read More

Magnesium in methanol(Mg / MeOH) system is an extremely versatile, efficient, economical and convenient reducing agent for various reactions useful for organic synthesis such as reductive cyclization, reductive elimination, reductive cleavage, reduction of a conjugated double bond, desulfonylation, and reduction of various functional groups. This comprehensive review is intended to highlight the use of Mg / MeOH in Read More