Current Organic Chemistry - Volume 8, Issue 10, 2004

I am please to once again be serving as the executive guest editor for Current Organic Chemistry's issue on molecular recognition. This volume will cover a wide range of topics related to molecular recognition ranging from small molecules to biomacromolecules. As usual I would like to thank all of the authors and the editorial staff for making this issue possible. The first review in this volume is a contribution from Ronald K. Castell Read More

Recent studies confirm that C-H...O hydrogen bonds have many, if not all, of the spectroscopic and physical earmarks of “traditional” H-bonds. Only more recently have we come to understand that these contacts are operative not only in protein-protein recognition, but enzyme-substrate interactions (with implications for drug design), biological and nonbiological transition state stabilization and have, in some circumstance Read More

Calix[4]arenes have been extensively studied for their ability to act as synthetic receptors for metal ions and small molecules and, more recently, for use as enzyme mimics and molecular capsules. While the literature on substituted calixarenes is extensive, calixarenes that are substituted with amino acids and peptides-i.e., peptidocalixarenes-have received relatively little attention. The use of peptidocalixarenes as hosts is attra Read More

The recognition of glycoprotein ligands by the selectins mediates leukocyte recruitment during an inflammatory response. Mimetics whose designs are based on the sialyl Lewis-x tetrasaccharide, common to these glycoproteins, have proven to be good inhibitors of leukocyte binding to the selectins. Some of the more recent approaches to the synthesis of these mimetics, including the use of polymeric and liposomal displays Read More

Microwave Assisted Organic Synthesis is known for the spectacular accelerations produced in many reactions as a consequence of heating rates that cannot be reproduced by classical heating. As a result, higher yields, milder reaction conditions and shorter reaction times can be achieved and many processes can be improved. Furthermore, reactions that do not occur by conventional heating can often be carried out under Read More

The review will focus on the recent progress achieved in the palladium-catalyzed oxidative carbonylation reactions of unsaturated substrates that has allowed the development of new, efficient and selective syntheses of a variety of carbonyl compounds. Coverage: until the end of 2002.