Current Organic Chemistry - Volume 8, Issue 11, 2004

Protein phosphatases are important in a sense that they regulate the phosphorylation level of various proteins and in turn many physiological processes. Aberration in a fine tune among protein phosphatases and their counterparts, protein kinases, results in various diseases. Hence, the inhibitors of these enzymes have gained importance in disease treatments. In recent years, some natural and synthetic compounds hav Read More

Pentaerythritol and its congeners, such as pentaerythrityltetramine, 2,2-bis(aminomethyl)propane-1,3- diol, bis(hydroxymethyl)malonic acid, bis(aminomethyl)malonic acid and 2,2-bis(aminomethyl)-β-alanine, constitute an interesting class of tetrafunctional spiro compounds that allow the attachment of four different conjugate groups and, hence, the construction of highly branched and branched / cyclized structures. Accor Read More

Aldol condensation of synthetic equivalents of acetacetic esters allows the formation of a polyfunctional C5 fragment and the corresponding aldols have proven to be versatile key-intermediates in the synthesis of complex, biologically active natural products. O-silyldienolates 1 and 2 can be considered among the most popular masked acetacetic esters and in these last years the silyl dienolate 1a (R1 = R2 = Me), deriving fro Read More

Lipases are biocatalysts most widely used in organic synthesis. Unusual but attractive feature of lipases is that, in addition to high catalytic activity and thermostability in organic solvents, lipases show high enantioselectivity and broad substrate specificity simultaneously. They show excellent enantioselectivity especially toward a wide range of secondary alcohols. The mechanistic details of stereoselective organic reactions are Read More

Aluminum (Al) is an ideal reducing agent (electron pool) since it is cheap, easy to handle, able to release enough electron (3 e- / atom), and environment friendly. However, the use of Al in organic synthesis is rather limited owing to lack of efficient electron transfer process between Al and organic substances. In last decay, we and some other groups developed multi-redox promoted reactions using Al as a terminal redu Read More