Current Organic Chemistry - Volume 8, Issue 14, 2004

The simple heterocycle 2-(3H)-oxazolone has long proven itself a versatile tool in the hands of the synthetic organic chemist. Its numerous derivatives have served in many roles - from activating groups in coupling reactions, to efficient and reliable chiral auxiliaries, as focal points for asymmetric catalysis, or more recently as a versatile synthon in target-oriented synthesis. Although several obvious comparisons are pr Read More

Chiral auxiliary-based reactions constitute one the most intense research areas in organic chemistry. During the last three decades (R)-pantolactone and to a minor extent its (S)-enantiomer have been used as very efficient chiral auxiliaries, thus contributing to the development of chiral auxiliary-based asymmetric synthesis as a common approach for the preparation of enantiomerically pure compounds. This revie Read More

The medical application of cardenolides and bufadienolides is associated with a high risk, due to their toxicity and the small difference between the therapeutic and toxic doses. In the past few years, increasing attention has been paid to the mechanism of cardiotonic action and the synthesis of cardenolide and bufadienolide analogs which are expected to have better therapeutic indices. A cardenolide analog in which the lactone Read More

Substituted tricarballylic acid has found many technical and biological applications and this reflected a number of such compounds synthesized to date. In this review an attempt has been made to be the only review appeared in the literature up to date. Presenting only a selection of synthetic interest and stereochemistry of tricarballylic acid moieties of some natural products. The important issues for the existing of the tricarb Read More