Current Organic Chemistry - Volume 8, Issue 12, 2004

The Baeyer-Villiger oxidation of ketones represents a powerful methodology in synthesis to break carbon-carbon bonds in an oxygen insertion process. Since the discovery of the reaction by Adolf Baeyer and Victor Villiger in 1899 substantial progress has been made to understand the mechanism, to predict migratory preference, and to apply this conversion in preparative chemistry. Chiral Baeyer-Villiger oxidation of cy Read More

Flash vacuum pyrolysis is an interesting methodology for studying reaction mechanisms as well as synthesis. Its characteristics of submitting the molecule to high temperature (350 - 900ºC) in a vacuum system (∼ 10-2 Torr) for a short time (∼ 10-2s) makes possible to isolate kinetically controlled products and, in some cases, to avoid consecutive reactions. Studies of reaction mechanisms may include kinetic and non-kin Read More

2(5H)-Furanone derivatives are a large family of heterocycles that include synthetically useful compounds, several natural products and drugs with diverse biological activities. From the 1960, there has been a continuous interest in the development of efficient methods for preparation of these heterocycles and in their synthetic applications. The studies in these fields have been summarised and discussed in several excellent rev Read More

The porphyrins and related tetrapyrrole systems are among the most widely studied of all macrocyclic compounds. In fact, in one capacity or another these versatile molecules have influenced nearly all disciplines in chemistry. In recent years, efforts are underway to develop tetrahydroporphyrin-based (bacteriochlorin) compounds with long wavelength absorption in the range of 700-800 nm as photosensitizer Read More

Over the course of the last decades, phosphinic peptides have emerged as an extremely important class of Zn-metalloprotease inhibitors. The intense interest in these compounds in the field of medicinal chemistry reflects a conjunction of synthetic advances and ideal physicochemical and biochemical properties. Among the latter, the optimal tetrahedral structure of phosphinic acid moiety, which perfectly fills the requirem Read More