Biology and Chemistry of Sphingosine-Related Metabolites

Martin Brunner; Ari M. P. Koskinen

doi:10.2174/1385272043369638

ISSN: 1385-2728
E-ISSN: 1875-5348

Biology and Chemistry of Sphingosine-Related Metabolites
Authors: Martin Brunner¹ and Ari M. P. Koskinen²
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Affiliations: ¹ Laboratory of Organic Chemistry, Helsinki University of Technology, PO Box 6100, FIN-02150 Espoo, Finland. ² Laboratory of Organic Chemistry, Helsinki University of Technology, PO Box 6100, FIN-02150 Espoo, Finland.
Source: Current Organic Chemistry, Volume 8, Issue 17, Nov 2004, p. 1629 - 1645
DOI: https://doi.org/10.2174/1385272043369638
- Available online: 01 Nov 2004

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Abstract

Metabolites of the thermophilic fungi Myriococcum albomyces and Mycelia sterilia such as myriocin (1), the mycestericins (2-8) and the sphingofungins (13-18) structurally resemble the sphingosines, important components of cell membranes. All the compounds revealed in vitro remarkable immunosuppressive activity and their pharmaceutical potential has led to the development of promising novel immunosuppressants. This review article describes the abundance, biology and chemistry of these metabolites.

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2004-11-01

2024-12-27

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Article Type: Review Article

Keyword(s): diseases; fermentation; homologues; immunosuppressant; isolation; myriocin; sphingosines; total syntheses

Biology and Chemistry of Sphingosine-Related Metabolites

Abstract

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