Current Organic Chemistry - Volume 8, Issue 16, 2004

Lithiated γ -chloroalkyl heterocycles are useful intermediates for the stereoselective construction of a number of heterocyclic systems. Prof. S. Florio, and co-workers University of Bari, Italy, discuss the potential and intricacies of this type of chemistry. Synthesis and pharmacological properties of 4-thiazolidones is the theme in the second chapter contributed by Drs R.B. Lesyk and B.S. Zimenkovsky from Danylo Halyts Read More

The chemistry of lithiated α-chloroalkylheterocycles such as α-chloroalkylbenzothiazoles, - benzotriazoles, -pyridines, -triazines, -thiazoles and -oxazolines has been reviewed. The synthetic application of this kind of chemistry for the stereoselective preparation of heteroaryl cyclopropanes, oxiranes, aziridines, alkenes and functionalised nitroarenes through a Darzens-type reaction, has been especially emphasised.

The potential of 4-thiazolidones (2,4-thiazolidinediones, 2-thioxo(imino)-4-thiazolidones) as drugs is under consideration by the pharmaceutical science since the beginning of the XX century. During recent years a new phase has been seen in this field. Centerarian history of synthetic research possibilities of these heterocycles lead to diversity in modelling biologically active compounds using 4-thiazolidone scaffolds. M Read More

The versatility and potential of reductive cyclisation as a route to 5-membered N-heterocyclic structures of diverse complexity is demonstrated through selected examples.

The versatility and potential of reductive cyclisation as a route to 6-membered N-heterocyclic structures of diverse complexity is demonstrated through selected examples.