Current Organic Chemistry - Volume 8, Issue 6, 2004

The inexpensive and commercially available chlorosulfonyl isocyanate reacts readily with the variety of nucleophilic olefins to provide unstable [2+2]cycloadducts. The reaction proceeds via concerted mechanism rather than a stepwise process. The electron-donating substituent in the olefin component controls the regiochemistry of the reaction. The cycloaddition is stereospecific, leading from (Z)-olefin to the cis-adduct and Read More

The D- and L-form 1,6-anhydrohexopyranoses are valuable building blocks in the synthesis of carbohydrate molecules as well as nature products. Their bicyclo[3.2.1]octane framework possesses rigid conformation that has several advantages and offers unique reactivity patterns in comparison with their corresponding hexopyranoses. A variety of practical and convenient routes developed for their preparation over past two dec Read More

Microwave irradiation is becoming an increasingly popular method of heating which replaces the classical one because it proves to be a clean, cheap, and convenient method. Often, it affords higher yields and results in shorter reaction times. This method of heating has been extended to almost all areas of chemistry with the exception of the carbohydrate chemistry which has suffered a certain delay, as it is testified by th Read More

This article will review the techniques used for the characterization of the N-linked oligosaccharides of glycoproteins to be used in enzyme replacement therapy (ERT), describe the specific role some of these oligosaccharides play in the delivery of these enzymes and outline the syntheses of some relevant fluorogenic and chromogenic carbohydrates that are not commercially available. Without being extensive, t Read More