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Lithiated γ -chloroalkyl heterocycles are useful intermediates for the stereoselective construction of a number of heterocyclic systems. Prof. S. Florio, and co-workers University of Bari, Italy, discuss the potential and intricacies of this type of chemistry. Synthesis and pharmacological properties of 4-thiazolidones is the theme in the second chapter contributed by Drs R.B. Lesyk and B.S. Zimenkovsky from Danylo Halytsky University, Lviv, Ukraine. The final two chapters, dealing with reductive cyclisation in the synthesis of 5- and 6-membered N-heterocycles have been contributed by Drs P.G. Tsoungas and A.I. Diplas form Athens and Patras, Greece, respectively.